Pulmonary Toxicity of Single-Wall Carbon Nanotubes in Mice 7 and 90 Days After Intratracheal Instillation
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TLDR
Results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more Toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.About:
This article is published in Toxicological Sciences.The article was published on 2003-09-26 and is currently open access. It has received 1954 citations till now. The article focuses on the topics: Carbon nanotubes in medicine & Carbon nanotube.read more
Citations
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Tuning the cellular uptake and cytotoxicity of carbon nanotubes by surface hydroxylation
TL;DR: It is demonstrated that surface hydrophilicity of MWCNTs could alter their cell uptake efficiency, underlining the possibility for rational design of CNT-specific surface properties for their further development in biomedical fields and a mechanistic understanding of observed CNT toxicity.
Journal ArticleDOI
Reactivity of engineered inorganic nanoparticles and carbon nanostructures in biological media
TL;DR: This review focuses on the particular physico-chemical properties of inorganic matter at the nanoscale in order to understand and track its evolution within living organisms, and thus monitor their interactions.
Journal ArticleDOI
Aerosolization of single-walled carbon nanotubes for an inhalation study.
Paul A. Baron,Gregory J. Deye,Bean T. Chen,Diane Schwegler-Berry,Anna A. Shvedova,Vincent Castranova +5 more
TL;DR: In this paper, an acoustic feeder system was designed to produce respirable aerosol at 5 mg/m(3) for a 1-week animal exposure for single-walled carbon nanotubes (SWCNT).
Regulation and Risk Assessment of Nanomaterials - Too Little, Too Late?
TL;DR: In this article, the authors investigate whether existing regulation is adequate in the short and the long term, explore the feasibility of risk assessment for the purpose of dealing with the complex emerging risks of nanomaterials, and finally, provide recommendations on how to govern nanotechnologies.
Journal ArticleDOI
Molybdenum nanoparticles-induced cytotoxicity, oxidative stress, G2/M arrest, and DNA damage in mouse skin fibroblast cells (L929).
Maqsood A. Siddiqui,Quaiser Saquib,Maqusood Ahamed,Nida N. Farshori,Javed Ahmad,Rizwan Wahab,Shams Tabrez Khan,Hisham A. Alhadlaq,Javed Musarrat,Abdulaziz A. Al-Khedhairy,Aditya B. Pant +10 more
TL;DR: It is demonstrated, for the first time, that molybdenum nanoparticles induced cytotoxicity, oxidative stress and genotoxicity in mouse skin fibroblast cells (L929), suggesting the potential hazardous nature of Mo-NPs.
References
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Journal ArticleDOI
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
TL;DR: Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition.
Journal ArticleDOI
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
Andrew G. Rinzler,Jie Liu,Hongjie Dai,Pavel Nikolaev,Chad B. Huffman,Fernando J. Rodríguez-Macías,Peter J. Boul,A.H. Lu,Dieter Heymann,Daniel T. Colbert,R. S. Lee,John E. Fischer,Apparao M. Rao,P. C. Eklund,Richard E. Smalley +14 more
TL;DR: A readily scalable purification process capable of handling single-wall carbon nanotube (SWNT) material in large batches, which should greatly facilitate investigation of material properties intrinsic to the nanotubes.
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
Andrew D. Maynard,Paul A. Baron,Michael Foley,Anna A. Shvedova,Elena R. Kisin,Vincent Castranova +5 more
TL;DR: Although laboratory studies indicated that with sufficient agitation, unrefined SWCNT material can release fine particles into the air, concentrations generated while handling material in the field were very low, and estimates of the airborne concen-tration of nanotube material generated during handling suggest that concentrations were lower than 53μg/m3 in all cases.
Journal ArticleDOI
Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study
TL;DR: The HiPco process has been used to produce high-purity carbon single-walled nanotubes (SWNTs) using a gas-phase chemical-vapor-deposition process as mentioned in this paper.
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