Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Sven Heinz,Christopher Benner,Nathanael J. Spann,Eric Bertolino,Yin C. Lin,Peter Laslo,Jason X. Cheng,Cornelis Murre,Harinder Singh,Harinder Singh,Christopher K. Glass +10 more
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TLDR
It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.About:
This article is published in Molecular Cell.The article was published on 2010-05-28 and is currently open access. It has received 9620 citations till now. The article focuses on the topics: Pioneer factor & General transcription factor.read more
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The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma
Ana Banito,Xiang Li,Aimée N. Laporte,Jae Seok Roe,Francisco Sanchez-Vega,Chun-Hao Huang,Amanda R. Dancsok,Katerina Hatzi,Chi-Chao Chen,Chi-Chao Chen,Darjus F. Tschaharganeh,Rohit Chandwani,Nilgun Tasdemir,Kevin B. Jones,Mario R. Capecchi,Christopher R. Vakoc,Nikolaus Schultz,Marc Ladanyi,Torsten O. Nielsen,Scott W. Lowe,Scott W. Lowe +20 more
TL;DR: SS18-SSX1 deregulates developmental programs to drive transformation by hijacking a transcriptional repressive complex to aberrantly activate gene expression in synovial sarcoma cells, leading to irreversible mesenchymal differentiation.
Journal ArticleDOI
YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction
Michele Gabriele,Anneke T. Vulto-van Silfhout,Pierre-Luc Germain,Alessandro Vitriolo,Raman Kumar,Evelyn Douglas,Eric Haan,Kenjiro Kosaki,Toshiki Takenouchi,Anita Rauch,Katharina Steindl,Eirik Frengen,Doriana Misceo,Christeen Ramane J. Pedurupillay,Petter Strømme,Jill A. Rosenfeld,Yunru Shao,William J. Craigen,Christian P. Schaaf,David Rodriguez-Buritica,Laura S. Farach,Jennifer Friedman,Perla Thulin,Scott D. McLean,Kimberly M. Nugent,Jenny Morton,Jillian Nicholl,Joris Andrieux,Asbjørg Stray-Pedersen,Pascal Chambon,Sophie Patrier,Sally Ann Lynch,Susanne Kjaergaard,Pernille Mathiesen Tørring,Charlotte Brasch-Andersen,Anne Ronan,Arie van Haeringen,Peter J. Anderson,Zöe Powis,Han G. Brunner,Rolph Pfundt,Janneke H M Schuurs-Hoeijmakers,Bregje W.M. van Bon,Stefan H. Lelieveld,Christian Gilissen,Willy M. Nillesen,Lisenka E.L.M. Vissers,Jozef Gecz,David A. Koolen,Giuseppe Testa,Giuseppe Testa,Bert B.A. de Vries +51 more
TL;DR: A clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators is defined, defined as a syndrome of cognitive impairment, behavioral alterations, intrauterine growth restriction, feeding problems, and various congenital malformations.
Journal ArticleDOI
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.
Jane Guan,Wei Zhou,Marc Hafner,Robert A. Blake,Cecile Chalouni,Irene P. Chen,Tom De Bruyn,Jennifer M. Giltnane,Steven J. Hartman,Amy Heidersbach,René Houtman,Ellen Ingalla,Lorn Kategaya,Tracy Kleinheinz,Jun Li,Scott E. Martin,Zora Modrusan,Michelle Nannini,Jason Oeh,Savita Ubhayakar,Xiaojing Wang,Ingrid E. Wertz,Amy Young,Mamie Yu,Deepak Sampath,Jeffrey H. Hager,Lori Friedman,Anneleen Daemen,Ciara Metcalfe +28 more
TL;DR: Mechanistically, fulvestrant-like antagonists suppress ER transcriptional activity not by ER elimination, but by markedly slowing the intra-nuclear mobility of ER, providing proof-of-concept that small molecule perturbation of transcription factor mobility may enable therapeutic targeting of this challenging target class.
Journal ArticleDOI
Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation.
TL;DR: This data build on prior reports documenting translational upregulation of the nutrient-responsive transcription factor Gcn4 in response to numerous tRNA perturbations, and identify many additional translationally regulated mRNAs throughout the yeast genome.
Journal ArticleDOI
Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding
TL;DR: This study establishes a novel approach to derive predictive cis-regulatory motif requirements for individual TF binding sites and enhancers from the increasing number of tissue- and cell-type-specific TF binding studies.
References
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TL;DR: This study uses chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing to map the locations of TF-binding sites and identifies important features of the transcriptional regulatory networks that define ES-cell identity.
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Hongcang Gu,Marius Wernig,Jacob H. Hanna,Andrey Sivachenko,Xiaolan Zhang,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,David B. Jaffe,Andreas Gnirke,Rudolf Jaenisch,Eric S. Lander +14 more
TL;DR: Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.