Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Sven Heinz,Christopher Benner,Nathanael J. Spann,Eric Bertolino,Yin C. Lin,Peter Laslo,Jason X. Cheng,Cornelis Murre,Harinder Singh,Harinder Singh,Christopher K. Glass +10 more
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TLDR
It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.About:
This article is published in Molecular Cell.The article was published on 2010-05-28 and is currently open access. It has received 9620 citations till now. The article focuses on the topics: Pioneer factor & General transcription factor.read more
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The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.
Christopher Benner,Talitha van der Meulen,Elena L. Caceres,Kristof Tigyi,Cynthia J. Donaldson,Mark O. Huising,Mark O. Huising +6 more
TL;DR: The comprehensive mouse alpha and beta cell transcriptomes complemented by the comparison of the global (dis)similarities between mouse and human beta cells represent invaluable resources to boost the accuracy by which rodent models offer guidance in finding cures for human diabetes.
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An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma
Esther Rheinbay,Mario L. Suvà,Mario L. Suvà,Mario L. Suvà,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Hiroaki Wakimoto,Anoop P. Patel,Mohammad Shahid,Ozgur Oksuz,Samuel D. Rabkin,Robert L. Martuza,Miguel Rivera,Miguel Rivera,David N. Louis,Simon Kasif,Andrew S. Chi,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +20 more
TL;DR: A comparative analysis of chromatin state in GBM CSCs is presented that reveals widespread activation of genes normally held in check by Polycomb repressors, and demonstrates regulatory connections among ASCL1, Wnt signaling, and collaborating TFs that are essential for the maintenance and tumorigenicity of GBMCSCs.
Journal ArticleDOI
Establishment and Maintenance of the Macrophage Niche.
TL;DR: This work examines recent studies that uncovered mutually beneficial cell-cell circuits established between macrophages and their niche and proposes a modular view of tissues that integrates the resident macrophage as an essential component of each individual module.
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Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
Shannon E. Mullican,Christine A. Gaddis,Theresa Alenghat,Meera G. Nair,Paul R. Giacomin,Logan J. Everett,Dan Feng,David J. Steger,Jonathan Schug,David Artis,Mitchell A. Lazar +10 more
TL;DR: It is reported that macrophages lacking histone deacetylase 3 (HDAC3) display a polarization phenotype similar to IL-4-induced alternative activation and, furthermore, are hyperresponsive to IL (IL-4) stimulation.
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Nonclassical Patrolling Monocyte Function in the Vasculature
TL;DR: Patrolling monocytes function in several disease settings to remove damaged cells and debris from the vasculature and have been associated with wound healing and the resolution of inflammation in damaged tissues.
References
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Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
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RAG-1-deficient mice have no mature B and T lymphocytes
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TL;DR: The introduction of a mutation in RAG-1 into the germline of mice via gene targeting in embryonic stem cells is described and it is shown that this mutation either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes.
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Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
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TL;DR: This study uses chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing to map the locations of TF-binding sites and identifies important features of the transcriptional regulatory networks that define ES-cell identity.
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Hongcang Gu,Marius Wernig,Jacob H. Hanna,Andrey Sivachenko,Xiaolan Zhang,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,David B. Jaffe,Andreas Gnirke,Rudolf Jaenisch,Eric S. Lander +14 more
TL;DR: Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.