Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Sven Heinz,Christopher Benner,Nathanael J. Spann,Eric Bertolino,Yin C. Lin,Peter Laslo,Jason X. Cheng,Cornelis Murre,Harinder Singh,Harinder Singh,Christopher K. Glass +10 more
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TLDR
It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.About:
This article is published in Molecular Cell.The article was published on 2010-05-28 and is currently open access. It has received 9620 citations till now. The article focuses on the topics: Pioneer factor & General transcription factor.read more
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METTL3-mediated m6A modification is required for cerebellar development.
Chenxin Wang,Guanshen Cui,Guanshen Cui,Xiuying Liu,Kai Xu,Meng Wang,Xin-Xin Zhang,Liyuan Jiang,Ang Li,Ang Li,Ying Yang,Weiyi Lai,Bao-Fa Sun,Bao-Fa Sun,Guibin Jiang,Hailin Wang,Wei-Min Tong,Wei Li,Xiu-Jie Wang,Yun-Gui Yang,Yun-Gui Yang,Qi Zhou +21 more
TL;DR: It is shown that specific inactivation of Mettl3 in mouse nervous system causes severe developmental defects in the brain, and a critical role of METTL3-mediated m6A in regulating the development of mammalian cerebellum is revealed.
Journal ArticleDOI
Maintaining cell identity through global control of genomic organization
TL;DR: P paradigmatic genetic and biochemical studies in immune system and hematopoietic cells strongly point to the concept that both induction and maintenance of the differentiated state require constant supervision by lineage-determining transcription factors, which may act to globally organize the genome in both the one- and the three-dimensional space.
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The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan
Dario Riccardo Valenzano,Bérénice A. Benayoun,Param Priya Singh,Elisa Zhang,Paul D. Etter,Chi-Kuo Hu,Mathieu Clément-Ziza,David Willemsen,Rongfeng Cui,Itamar Harel,Ben Machado,Muh-Ching Yee,Sabrina C. Sharp,Carlos Bustamante,Andreas Beyer,Eric A. Johnson,Anne Brunet +16 more
TL;DR: A reference genome is assembled for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics and the identification of genes under positive selection in this fish reveals potential candidates to explain its compressed lifespan.
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Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Erinn Soucie,Ziming Weng,Laufey Geirsdóttir,Laufey Geirsdóttir,Laufey Geirsdóttir,Kaaweh Molawi,Julien Maurizio,Julien Maurizio,Julien Maurizio,Romain Fenouil,Romain Fenouil,Romain Fenouil,Noushine Mossadegh-Keller,Noushine Mossadegh-Keller,Noushine Mossadegh-Keller,Gregory Gimenez,Gregory Gimenez,Gregory Gimenez,Laurent Vanhille,Laurent Vanhille,Laurent Vanhille,Meryam Beniazza,Meryam Beniazza,Meryam Beniazza,Jeremy Favret,Jeremy Favret,Jeremy Favret,Carole Berruyer,Carole Berruyer,Carole Berruyer,Pierre Perrin,Pierre Perrin,Pierre Perrin,Nir Hacohen,Jean-Christophe Andrau,Pierre Ferrier,Pierre Ferrier,Pierre Ferrier,Patrice Dubreuil,Arend Sidow,Michael H. Sieweke +40 more
TL;DR: It is reported that in macrophages at homeostasis, a pair of transcription factors (MafB and c-Maf) bind to and repress the enhancers of genes regulating self-renewal, and how these mechanisms activate macrophage self-Renewal under homeostatic and challenge conditions in vivo is investigated.
Journal ArticleDOI
Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis
Jun Xiao,Run Jin,Xiang Yu,Max W. Shen,John D. Wagner,Armaan Pai,Claire Song,Michael Zhuang,Samantha Klasfeld,Chongsheng He,Alexandre M Santos,Chris A. Helliwell,Jose L. Pruneda-Paz,Steve A. Kay,Xiaowei Lin,Sujuan Cui,Meilin Fernandez Garcia,Oliver Clarenz,Justin Goodrich,Xiaoyu Zhang,Ryan S. Austin,Roberto Bonasio,Doris Wagner +22 more
TL;DR: Short genomic fragments, known as Polycomb response elements (PREs), that direct Polycomb repressive complex 2 (PRC2) placement at developmental genes regulated by silencing in Arabidopsis thaliana are defined.
References
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Hongcang Gu,Marius Wernig,Jacob H. Hanna,Andrey Sivachenko,Xiaolan Zhang,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,David B. Jaffe,Andreas Gnirke,Rudolf Jaenisch,Eric S. Lander +14 more
TL;DR: Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.