Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Sven Heinz,Christopher Benner,Nathanael J. Spann,Eric Bertolino,Yin C. Lin,Peter Laslo,Jason X. Cheng,Cornelis Murre,Harinder Singh,Harinder Singh,Christopher K. Glass +10 more
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TLDR
It is demonstrated in macrophages and B cells that collaborative interactions of the common factor PU.1 with small sets of macrophage- or B cell lineage-determining transcription factors establish cell-specific binding sites that are associated with the majority of promoter-distal H3K4me1-marked genomic regions.About:
This article is published in Molecular Cell.The article was published on 2010-05-28 and is currently open access. It has received 9620 citations till now. The article focuses on the topics: Pioneer factor & General transcription factor.read more
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EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production.
Muyao Guo,Muyao Guo,Madeline J. Price,Dillon G. Patterson,Benjamin G. Barwick,Robert R. Haines,Anna K. Kania,John E. Bradley,Troy D. Randall,Jeremy M. Boss,Christopher D. Scharer +10 more
TL;DR: Examination of ASC differentiation independent of T cell help and germinal center reactions using mice with inducible or B cell–specific deletions of Ezh2 demonstrates that EZH2 is essential in facilitating epigenetic changes that regulate ASC fate, function, and metabolism.
Journal ArticleDOI
Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
Alfonso Urbanucci,Stefan J Barfeld,Ville Kytölä,Harri M. Itkonen,Ilsa Coleman,Daniel Vodak,Liisa Sjöblom,Xia Sheng,Teemu Tolonen,Sarah Minner,Christoph Burdelski,Kati Kivinummi,Annika Kohvakka,Steven Kregel,Steven Kregel,Mandeep Takhar,Mohammed Alshalalfa,Elai Davicioni,Nicholas Erho,Paul Lloyd,R. Jeffrey Karnes,Ashley E. Ross,Edward M. Schaeffer,Donald J. Vander Griend,Stefan Knapp,Stefan Knapp,Eva Corey,Felix Y. Feng,Peter S. Nelson,Peter S. Nelson,Fahri Saatcioglu,Karen E. Knudsen,Teuvo L.J. Tammela,Guido Sauter,Thorsten Schlomm,Matti Nykter,Tapio Visakorpi,Ian G. Mills,Ian G. Mills +38 more
TL;DR: It is shown that chromatin accessibility defines castration-resistant prostate cancer (CRPC) and that the deregulation of androgen receptor (AR) expression is a driver of chromatin relaxation and that AR/androgen-regulated bromodomain-containing proteins (BRDs) mediate this effect.
Journal ArticleDOI
Estimating Sample-Specific Regulatory Networks
Marieke L. Kuijjer,Matthew Tung,Guo-Cheng Yuan,John Quackenbush,John Quackenbush,Kimberly Glass,Kimberly Glass +6 more
TL;DR: In this paper, the authors propose a method to reverse engineer sample-specific networks from aggregate networks, and demonstrate their approach in several contexts, including simulated, yeast microarray, and human lymphoblastoid cell line RNA sequencing data.
Journal ArticleDOI
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
Elahu G. Sustarsic,Tao Ma,Matthew D. Lynes,Michael Larsen,Iuliia Karavaeva,Jesper F. Havelund,Carsten H. Nielsen,Mark P. Jedrychowski,Marta Moreno-Torres,Morten Lundh,Kaja Plucinska,Naja Z. Jespersen,Trisha J. Grevengoed,Barbara Kramar,Julia Peics,Jakob Bondo Hansen,Farnaz Shamsi,Isabel Forss,Ditte Neess,Susanne Keipert,Jianing Wang,Katharina Stohlmann,Ivan Brandslund,Cramer Christensen,Marit E. Jørgensen,Marit E. Jørgensen,Allan Linneberg,Allan Linneberg,Oluf Pedersen,Michael A. Kiebish,Klaus Qvortrup,Xianlin Han,Bente Klarlund Pedersen,Martin Jastroch,Susanne Mandrup,Andreas Kjaer,Steven P. Gygi,Torben Hansen,Matthew P. Gillum,Niels Grarup,Brice Emanuelli,Søren Nielsen,Camilla Scheele,Yu-Hua Tseng,Nils J. Færgeman,Zachary Gerhart-Hines +45 more
TL;DR: It is shown that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenicfat function and has a powerful impact on organismal energy homeostasis through thermogenic fat bioenergetics.
Journal ArticleDOI
Global Analysis of the RNA-Protein Interaction and RNA Secondary Structure Landscapes of the Arabidopsis Nucleus
Sager J. Gosai,Shawn W. Foley,Dongxue Wang,Ian M. Silverman,Nur Selamoglu,Andrew D. L. Nelson,Mark A. Beilstein,Fevzi Daldal,Roger B. Deal,Brian D. Gregory +9 more
TL;DR: In this paper, a comprehensive view of the structural and RNA-binding interaction landscape of nuclear RNAs has been compiled for any organism, using their ribonuclease-mediated structure and RBP-binding site mapping approaches to globally profile these features in Arabidopsis seedling nuclei.
References
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Hongcang Gu,Marius Wernig,Jacob H. Hanna,Andrey Sivachenko,Xiaolan Zhang,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,David B. Jaffe,Andreas Gnirke,Rudolf Jaenisch,Eric S. Lander +14 more
TL;DR: Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.