C
Christopher A. Haiman
Researcher at University of Southern California
Publications - 783
Citations - 65352
Christopher A. Haiman is an academic researcher from University of Southern California. The author has contributed to research in topics: Breast cancer & Genome-wide association study. The author has an hindex of 106, co-authored 687 publications receiving 54813 citations. Previous affiliations of Christopher A. Haiman include University of California, San Francisco & National Institutes of Health.
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Journal ArticleDOI
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
Karol Estrada,Karol Estrada,Ingvild Aukrust,Ingvild Aukrust,Lise Bjørkhaug,Noël P. Burtt,Josep M. Mercader,Humberto García-Ortiz,Alicia Huerta-Chagoya,Hortensia Moreno-Macías,Geoffrey A. Walford,Jason Flannick,Amy L. Williams,Amy L. Williams,María José Gómez-Vázquez,Juan Carlos Fernández-López,Angélica Martínez-Hernández,Silvia Jiménez-Morales,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Córdova,Xavier Soberón,María Elena González-Villalpando,E. Henderson,Lynne R. Wilkens,Loic Le Marchand,Olimpia Arellano-Campos,María Luisa Ordóñez-Sánchez,Maribel Rodríguez-Torres,Rosario Rodríguez-Guillén,Laura Riba,Laeya A. Najmi,Suzanne B.R. Jacobs,Timothy Fennell,Stacey Gabriel,Pierre Fontanillas,Craig L. Hanis,Donna M. Lehman,Christopher P. Jenkinson,Hanna E. Abboud,Graeme I. Bell,Maria L. Cortes,Michael Boehnke,Clicerio Gonzalez-Villalpando,Lorena Orozco,Christopher A. Haiman,Teresa Tusie-Luna,Carlos A. Aguilar-Salinas,David Altshuler,Pål R. Njølstad,Jose C. Florez,Jose C. Florez,Daniel G. MacArthur,Daniel G. MacArthur +55 more
TL;DR: A single low-frequency variant in the MODY3-causing gene HNF1A that is associated with type 2 diabetes in Latino populations and may affect protein function is identified and may have implications for screening and therapeutic modification in this population.
Journal ArticleDOI
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
Christopher A. Haiman,Gary K. Chen,William J. Blot,Sara S. Strom,Sonja I. Berndt,Rick A. Kittles,Benjamin A. Rybicki,William B. Isaacs,Sue A. Ingles,Janet L. Stanford,W. Ryan Diver,John S. Witte,Ann W. Hsing,Barbara Nemesure,Timothy R. Rebbeck,Kathleen A. Cooney,Jianfeng Xu,Adam S. Kibel,Jennifer J. Hu,Esther M. John,Serigne Magueye Gueye,Stephen Watya,Lisa B. Signorello,Richard B. Hayes,Zhaoming Wang,Edward D. Yeboah,Yao Tettey,Qiuyin Cai,Suzanne Kolb,Elaine A. Ostrander,Charnita Zeigler-Johnson,Yuko Yamamura,Christine Neslund-Dudas,Jennifer Haslag-Minoff,William Wu,Venetta Thomas,Glenn O. Allen,Adam B. Murphy,Bao Li Chang,S. Lilly Zheng,M. Cristina Leske,Suh Yuh Wu,Anna M. Ray,Anselm Hennis,Anselm Hennis,Michael J. Thun,John D. Carpten,Graham Casey,Erin N. Carter,Edder R. Duarte,Lucy Xia,Xin Sheng,Peggy Wan,Loreall Pooler,Iona Cheng,Kristine R. Monroe,Fredrick R. Schumacher,Loic Le Marchand,Laurence N. Kolonel,Stephen J. Chanock,David Van Den Berg,Daniel O. Stram,Brian E. Henderson +62 more
TL;DR: A new risk variant on chromosome 17q21 is identified, ∼5% in men of African descent, whereas it is rare in other populations (<1%).
Journal ArticleDOI
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
Juliet D. French,Maya Ghoussaini,Stacey L. Edwards,Kerstin B. Meyer,Kyriaki Michailidou,Shahana Ahmed,Sofia Khan,Mel Maranian,Martin O'Reilly,Kristine M. Hillman,Joshua A. Betts,Thomas L. Carroll,Peter Bailey,Ed Dicks,Jonathan Beesley,Jonathan Tyrer,Ana-Teresa Maia,Andrew H. Beck,Nicholas W. Knoblauch,Constance Chen,Peter Kraft,Daniel R. Barnes,Anna González-Neira,M. Rosario Alonso,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Don M. Conroy,Joe Dennis,Manjeet K. Bolla,Qin Wang,John L. Hopper,Melissa C. Southey,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Peter A. Fasching,Peter A. Fasching,Christian R. Loehberg,Arif B. Ekici,Matthias W. Beckmann,Julian Peto,Isabel dos Santos Silva,Nichola Johnson,Zoe Aitken,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Roger L. Milne,M. Pilar Zamora,Jose Ignacio Arias Perez,Javier Benitez,Hoda Anton-Culver,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Alfons Meindl,Peter Lichtner,Rita K. Schmutzler,Christoph Engel,Hiltrud Brauch,Ute Hamann,Christina Justenhoven,Kirsimari Aaltonen,Päivi Heikkilä,Kristiina Aittomäki,Carl Blomqvist,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Aiko Sueta,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Annika Lindblom,Sara Margolin,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Diether Lambrechts,Stéphanie Peeters,Ann Smeets,Giuseppe Floris,Jenny Chang-Claude,Anja Rudolph,Stefan Nickels,Dieter Flesch-Janys,Dieter Flesch-Janys,Paolo Radice,Paolo Peterlongo,Bernardo Bonanni,Domenico Sardella,Fergus J. Couch,Xianshu Wang,Vernon S. Pankratz,Adam M. Lee,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Jacques Simard,Mark S. Goldberg,Martine Dumont,Soo Hwang Teo,Cheng Har Yip,Char Hong Ng,Eranga N. Vithana,Vessela N. Kristensen,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Peter Devilee,Caroline M. Seynaeve,Montserrat Garcia-Closas,Jonine D. Figueroa,Stephen J. Chanock,Jolanta Lissowska,Kamila Czene,Daniel Klevebring,Nils Schoof,Maartje J. Hooning,John W.M. Martens,J. Margriet Collée,Madeleine M.A. Tilanus-Linthorst,Per Hall,Jingmei Li,Jianjun Liu,Keith Humphreys,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Angela Cox,Sabapathy P. Balasubramanian,William Blot,Lisa B. Signorello,Qiuyin Cai,Paul D.P. Pharoah,Catherine S. Healey,Mitul Shah,Karen A. Pooley,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Mikael Hartman,Hui Miao,J. H. Sng,Xueling Sim,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Suleeporn Sangrajrang,Valerie Gaborieau,James McKay,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Andrew K. Godwin,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Shou Tung Chen,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Bruce A.J. Ponder,Heli Nevanlinna,Melissa A. Brown,Georgia Chenevix-Trench,Douglas F. Easton,Alison M. Dunning +214 more
TL;DR: Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13, and Chromatin conformation studies demonstrate that these enhancer and silencer elements interact with each other and with their likely target gene, CCND1.
Journal ArticleDOI
Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent
Timothy R. Rebbeck,Susan S. Devesa,Baoli Chang,Clareann H. Bunker,Iona Cheng,Kathleen A. Cooney,Rosalind A. Eeles,Pedro L. Fernández,Veda N. Giri,Serigne Magueye Gueye,Christopher A. Haiman,Brian E. Henderson,Chris F. Heyns,Jennifer J. Hu,Sue A. Ingles,William B. Isaacs,Mohamed Jalloh,Esther M. John,Adam S. Kibel,LaCreis R. Kidd,Penelope Layne,Robin J. Leach,Christine Neslund-Dudas,Michael N. Okobia,Elaine A. Ostrander,Jong Y. Park,Alan L. Patrick,Catherine M. Phelan,Camille Ragin,Robin Roberts,Benjamin A. Rybicki,Janet L. Stanford,Sara S. Strom,Ian M. Thompson,John S. Witte,Jianfeng Xu,Edward D. Yeboah,Ann W. Hsing,Charnita Zeigler-Johnson +38 more
TL;DR: A higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons reported lower mortality rates, suggesting that CaP is underdiagnosed and/or underreported in SSA men.
Journal ArticleDOI
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
David V. Conti,Burcu F. Darst,Lilit C. Moss,Edward J. Saunders,Xin Sheng,Alisha Chou,Fredrick R. Schumacher,Ali Amin Al Olama,Sara Benlloch,Tokhir Dadaev,Mark N. Brook,Ali Sahimi,Thomas J. Hoffmann,Atushi Takahashi,Koichi Matsuda,Yukihide Momozawa,Masashi Fujita,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Peggy Wan,Loic Le Marchand,Lynne R. Wilkens,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Graham G. Giles,Graham G. Giles,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Stig E. Bojesen,Martin Andreas Røder,Peter Iversen,Jyotsna Batra,Suzanne K. Chambers,Leire Moya,Lisa G. Horvath,Judith A. Clements,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Robert Szulkin,Martin Eklund,Tobias Nordström,Nora Pashayan,Alison M. Dunning,Maya Ghoussaini,Ruth C. Travis,Timothy J. Key,Elio Riboli,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Demetrius Albanes,Stephanie J. Weinstein,Lorelei A. Mucci,Edward Giovannucci,Sara Lindström,Peter Kraft,David J. Hunter,Kathryn L. Penney,Constance Turman,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Robert J. Hamilton,Robert J. Hamilton,Neil Fleshner,Antonio Finelli,Marie-Élise Parent,Marie-Élise Parent,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Milan S. Geybels,Stella Koutros,Laura E. Beane Freeman,Meir J. Stampfer,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Gerald L. Andriole,Robert N. Hoover,Mitchell J. Machiela,Karina Dalsgaard Sørensen,Michael Borre,William J. Blot,Wei Zheng,Edward D. Yeboah,Edward D. Yeboah,James E. Mensah,James E. Mensah,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Yudong Wu,Shan Chao Zhao,Zan Sun,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Catharine M L West,Neil G. Burnet,Gill Barnett,Christiane Maier,Thomas J. Schnoeller,Manuel Luedeke,Adam S. Kibel,Bettina F. Drake,Olivier Cussenot,Geraldine Cancel-Tassin,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Esther M. John,Eli Marie Grindedal,Lovise Maehle,Kay-Tee Khaw,Sue A. Ingles,Mariana C. Stern,Ana Vega,Antonio Gómez-Caamaño,Laura Fachal,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Andreia Brandão,Stephen Watya,Alexander Lubwama,Jeannette T. Bensen,Elizabeth T. H. Fontham,James L. Mohler,James L. Mohler,Jack A. Taylor,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Craig C. Teerlink,Craig C. Teerlink,Chad D. Huff,Sara S. Strom,Luc Multigner,Pascal Blanchet,Laurent Brureau,Radka Kaneva,Chavdar Slavov,Vanio Mitev,Robin J. Leach,Brandi Weaver,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Kai Uwe Saum,Eric A. Klein,Ann W. Hsing,Rick A. Kittles,Adam B. Murphy,Christopher J. Logothetis,Jeri Kim,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,William B. Isaacs,Barbara Nemesure,Anselm Hennis,Anselm Hennis,John D. Carpten,Hardev Pandha,Agnieszka Michael,Kim De Ruyck,Gert De Meerleer,Piet Ost,Jianfeng Xu,Azad Hassan Abdul Razack,Jasmine Lim,Soo-Hwang Teo,Lisa F. Newcomb,Daniel W. Lin,Jay H. Fowke,Christine Neslund-Dudas,Benjamin A. Rybicki,Marija Gamulin,Davor Lessel,Tomislav Kuliš,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Manuela Gago-Dominguez,Manuela Gago-Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Samantha E.T. Larkin,Paul A. Townsend,Paul A. Townsend,Claire Aukim-Hastie,William S. Bush,Melinda C. Aldrich,Dana C. Crawford,Shiv Srivastava,Jennifer Cullen,Gyorgy Petrovics,Graham Casey,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Jennifer J. Hu,Maureen Sanderson,Rohit Varma,Roberta McKean-Cowdin,Mina Torres,Nicholas Mancuso,Sonja I. Berndt,Stephen K. Van Den Eeden,Stephen K. Van Den Eeden,Douglas F. Easton,Stephen J. Chanock,Michael B. Cook,Fredrik Wiklund,Hidewaki Nakagawa,John S. Witte,Rosalind A. Eeles,Rosalind A. Eeles,Zsofia Kote-Jarai,Christopher A. Haiman +254 more
TL;DR: This paper conducted a meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants.