J
Johanna Schleutker
Researcher at Turku University Hospital
Publications - 217
Citations - 13369
Johanna Schleutker is an academic researcher from Turku University Hospital. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 50, co-authored 202 publications receiving 11537 citations. Previous affiliations of Johanna Schleutker include deCODE genetics & National Institutes of Health.
Papers
More filters
Journal Article
ELAC2/HPC2 Involvement in Hereditary and Sporadic Prostate Cancer
Annika Rökman,Tarja Ikonen,Nina Mononen,Ville Autio,Mika P. Matikainen,Pasi A. Koivisto,Teuvo L.J. Tammela,Olli-P. Kallioniemi,Johanna Schleutker +8 more
TL;DR: It is concluded that rare variants of the ELAC2/HPC2 truncating mutations require additional study as risk factors for PRCA in the general population, but none of the mutations were truncating.
Journal ArticleDOI
Shared heritability and functional enrichment across six solid cancers
Xia Jiang,Hilary K. Finucane,Fredrick R. Schumacher,Stephanie L. Schmit,Jonathan Tyrer,Younghun Han,Kyriaki Michailidou,Corina Lesseur,Karoline Kuchenbaecker,Joe Dennis,David V. Conti,Graham Casey,Mia M. Gaudet,Jeroen R. Huyghe,Demetrius Albanes,Melinda C. Aldrich,Angeline S. Andrew,Irene L. Andrulis,Hoda Anton-Culver,Antonis C. Antoniou,Natalia Antonenkova,Susanne M. Arnold,Kristan J. Aronson,Banu Arun,Elisa V. Bandera,Rosa B. Barkardottir,Daniel R. Barnes,Jyotsna Batra,Matthias W. Beckmann,Javier Benitez,Sara Benlloch,Andrew Berchuck,Sonja I. Berndt,Heike Bickeböller,Stephanie A. Bien,Carl Blomqvist,Stefania Boccia,Natalia Bogdanova,Stig E. Bojesen,Manjeet K. Bolla,Hiltrud Brauch,Hermann Brenner,James D. Brenton,Mark N. Brook,Joan Brunet,Hans Brunnström,Daniel D. Buchanan,Barbara Burwinkel,Ralf Bützow,Gabriella Cadoni,Trinidad Caldés,Maria A. Caligo,Ian G. Campbell,Peter T. Campbell,Geraldine Cancel-Tassin,Lisa A. Cannon-Albright,Daniele Campa,Neil E. Caporaso,André Lopes Carvalho,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,Chu Chen,David C. Christiani,Kathleen Claes,Frank Claessens,Judith A. Clements,J. Margriet Collée,Marcia Cruz Correa,Fergus J. Couch,Angela Cox,Julie M. Cunningham,Cezary Cybulski,Kamila Czene,Mary B. Daly,Anna deFazio,Peter Devilee,Orland Diez,Manuela Gago-Dominguez,Jenny L Donovan,Thilo Dörk,Eric J. Duell,Alison M. Dunning,Miriam Dwek,Diana Eccles,Christopher K. Edlund,Digna R. Velez Edwards,Carolina Ellberg,D. Gareth Evans,Peter A. Fasching,Robert L. Ferris,Triantafillos Liloglou,Jane C. Figueiredo,Olivia Fletcher,Renée T. Fortner,Florentia Fostira,Silvia Franceschi,Eitan Friedman,Steven Gallinger,Patricia A. Ganz,Judy Garber,José A. García-Sáenz,Simon A. Gayther,Graham G. Giles,Andrew K. Godwin,Mark S. Goldberg,David E. Goldgar,Ellen L. Goode,Marc T. Goodman,Gary E. Goodman,Kjell Grankvist,Mark H. Greene,Henrik Grönberg,Jacek Gronwald,Pascal Guénel,Niclas Håkansson,Per Hall,Ute Hamann,Freddie C. Hamdy,Robert J. Hamilton,Jochen Hampe,Aage Haugen,Florian Heitz,Rolando Herrero,Peter Hillemanns,Michael Hoffmeister,Estrid Høgdall,Yun-Chul Hong,John L. Hopper,Richard S. Houlston,Peter J. Hulick,David J. Hunter,David G. Huntsman,Gregory Idos,Evgeny N. Imyanitov,Sue A. Ingles,Claudine Isaacs,Anna Jakubowska,Paul A. James,Mark A. Jenkins,Mattias Johansson,Mikael Johansson,Esther M. John,Amit Joshi,Radka Kaneva,Beth Y. Karlan,Linda E. Kelemen,Tabea Kühl,Kay-Tee Khaw,Elza Khusnutdinova,Adam S. Kibel,Lambertus A. Kiemeney,Jeri Kim,Susanne K. Kjaer,Julia A. Knight,Manolis Kogevinas,Zsofia Kote-Jarai,Stella Koutros,Vessela N. Kristensen,Jolanta Kupryjanczyk,Martin Lacko,Stephan Lam,Diether Lambrechts,Maria Teresa Landi,Philip Lazarus,Nhu D. Le,Eunjung Lee,Flavio Lejbkowicz,Heinz-Josef Lenz,Goska Leslie,Davor Lessel,Jenny Lester,Douglas A. Levine,Li Li,Christopher I. Li,Annika Lindblom,Noralane M. Lindor,Geoffrey Liu,Fotios Loupakis,Jan Lubinski,Lovise Maehle,Christiane Maier,Arto Mannermaa,Loic Le Marchand,Sara Margolin,Taymaa May,Lesley McGuffog,Alfons Meindl,Pooja Middha,Austin Miller,Roger L. Milne,Robert J. MacInnis,Francesmary Modugno,Marco Montagna,Victor Moreno,Kirsten B. Moysich,Lorelei A. Mucci,Kenneth Muir,Anna Marie Mulligan,Katherine L. Nathanson,David E. Neal,Andy R Ness,Susan L. Neuhausen,Heli Nevanlinna,Polly A. Newcomb,Lisa F. Newcomb,Finn Cilius Nielsen,Liene Nikitina-Zake,Børge G. Nordestgaard,Robert L. Nussbaum,Kenneth Offit,Edith Olah,Ali Amin Al Olama,Olufunmilayo I. Olopade,Andrew F. Olshan,Håkan Olsson,Ana Osorio,Hardev Pandha,Jong Y. Park,Nora Pashayan,Michael T. Parsons,Tanja Pejovic,Kathryn L. Penney,Wilbert H.M. Peters,Catherine M. Phelan,Amanda I. Phipps,Dijana Plaseska-Karanfilska,Miranda Pring,Darya Prokofyeva,Paolo Radice,Kari Stefansson,Susan J. Ramus,Leon Raskin,Gad Rennert,Hedy S. Rennert,Elizabeth J. van Rensburg,Marjorie J. Riggan,Harvey A. Risch,Angela Risch,Monique J. Roobol,Barry S. Rosenstein,Mary Anne Rossing,Kim De Ruyck,Emmanouil Saloustros,Dale P. Sandler,Elinor J. Sawyer,Matthew B. Schabath,Johanna Schleutker,Marjanka K. Schmidt,V. Wendy Setiawan,Hongbing Shen,Erin M. Siegel,Weiva Sieh,Christian F. Singer,Martha L. Slattery,Karina Dalsgaard Sørensen,Melissa C. Southey,Amanda B. Spurdle,Janet L. Stanford,Victoria L. Stevens,Sebastian Stintzing,Jennifer Stone,Karin Sundfeldt,Rebecca Sutphen,Anthony J. Swerdlow,Eloiza H. Tajara,Catherine M. Tangen,Adonina Tardón,Jack A. Taylor,M. Dawn Teare,Manuel R. Teixeira,Mary Beth Terry,Kathryn L. Terry,Stephen N. Thibodeau,Mads Thomassen,Line Bjørge,Marc Tischkowitz,Amanda E. Toland,Diana Torres,Paul A. Townsend,Ruth C. Travis,Nadine Tung,Shelley S. Tworoger,Cornelia M. Ulrich,Nawaid Usmani,Celine M. Vachon,Els Van Nieuwenhuysen,Ana Vega,Miguel E. Aguado-Barrera,Qin Wang,Penelope M. Webb,Clarice R. Weinberg,Stephanie J. Weinstein,Mark C. Weissler,Jeffrey N. Weitzel,Catharine M L West,Emily White,Emily White,Alice S. Whittemore,H-Erich Wichmann,Fredrik Wiklund,Robert Winqvist,Alicja Wolk,Penella J. Woll,Michael O. Woods,Anna H. Wu,Xifeng Wu,Drakoulis Yannoukakos,Wei Zheng,Shanbeh Zienolddiny,Argyrios Ziogas,Kristin K. Zorn,Jacqueline M. Lane,Richa Saxena,Duncan Thomas,Rayjean J. Hung,Brenda Diergaarde,James D. McKay,Ulrike Peters,Li Hsu,Montserrat Garcia-Closas,Rosalind A. Eeles,Georgia Chenevix-Trench,Paul Brennan,Christopher A. Haiman,Jacques Simard,Douglas F. Easton,Stephen B. Gruber,Paul D.P. Pharoah,Alkes L. Price,Bogdan Pasaniuc,Christopher I. Amos,Peter Kraft,Sara Lindström +333 more
TL;DR: The authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry to show that solid tumours arising from different tissues share a degree of common germline genetic basis.
Journal Article
Two Percent of Finnish Prostate Cancer Patients Have a Germ-line Mutation in the Hormone-binding Domain of the Androgen Receptor Gene
Nina Mononen,Kirsi Syrjäkoski,Mika P. Matikainen,Teuvo L.J. Tammela,Johanna Schleutker,Olli-P. Kallioniemi,Jan Trapman,Pasi A. Koivisto +7 more
TL;DR: It is indicated that the R726L substitution in the AR may confer an up to 6-fold increased risk of prostate cancer and may contribute to cancer development in up to 2% of Finnish prostate cancer patients.
Journal ArticleDOI
The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium
Neil M Davies,Tom R. Gaunt,Sarah J Lewis,Jeffrey M P Holly,Jenny L Donovan,Freddie C. Hamdy,John P. Kemp,Rosalind A. Eeles,Doug Easton,Zsofia Kote-Jarai,Ali Amin Al Olama,Sara Benlloch,Kenneth Muir,Graham G. Giles,Fredrik Wiklund,Henrik Grönberg,Christopher A. Haiman,Johanna Schleutker,Børge G. Nordestgaard,Ruth C. Travis,David E. Neal,Nora Pashayan,Kay-Tee Khaw,Janet L. Stanford,William J. Blot,Stephen N. Thibodeau,Christiane Maier,Adam S. Kibel,Cezary Cybulski,Lisa A. Cannon-Albright,Hermann Brenner,Jong Y. Park,Radka Kaneva,Jyotsna Batra,Manuel R. Teixeira,Hardev Pandha,Mark Lathrop,George Davey Smith,Richard M. Martin +38 more
TL;DR: Genetically elevated height and BMI were associated with increased mortality (prostate cancer-specific and all-cause, respectively) in men with low-grade disease, a potentially informative but novel finding that requires replication.
Journal ArticleDOI
Androgen receptor CAG polymorphism and prostate cancer risk.
Nina Mononen,Tarja Ikonen,Ville Autio,Annika Rökman,Mika P. Matikainen,Teuvo L.J. Tammela,Olli-P. Kallioniemi,Pasi A. Koivisto,Johanna Schleutker +8 more
TL;DR: The results suggest that the CAG polymorphism of the AR gene is unlikely to have a major role in the development or progression of PC in the Finnish population, and the association of CAG repeats with the risk of BPH warrants further study.