L
Lyudmila Georgieva
Researcher at Cardiff University
Publications - 58
Citations - 25941
Lyudmila Georgieva is an academic researcher from Cardiff University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 34, co-authored 57 publications receiving 22546 citations. Previous affiliations of Lyudmila Georgieva include Sofia Medical University & University of Wales.
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Journal ArticleDOI
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mueller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Anders D. Børglum,Sven Cichon,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Journal ArticleDOI
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Shaun Purcell,Shaun Purcell,Naomi R. Wray,Jennifer Stone,Jennifer Stone,Peter M. Visscher,Michael Conlon O'Donovan,Patrick F. Sullivan,Pamela Sklar,Pamela Sklar,Douglas M. Ruderfer,Andrew McQuillin,Derek W. Morris,Colm O'Dushlaine,Aiden Corvin,Peter Holmans,Stuart MacGregor,Hugh Gurling,Douglas Blackwood,Nicholas John Craddock,Michael Gill,Christina M. Hultman,Christina M. Hultman,George Kirov,Paul Lichtenstein,Walter J. Muir,Michael John Owen,Carlos N. Pato,Edward M. Scolnick,Edward M. Scolnick,David St Clair,Nigel Williams,Lyudmila Georgieva,Ivan Nikolov,Nadine Norton,Hywel Williams,Draga Toncheva,Vihra Milanova,Emma Flordal Thelander,Patrick Sullivan,Elaine Kenny,Emma M. Quinn,Khalid Choudhury,Susmita Datta,Jonathan Pimm,Srinivasa Thirumalai,Vinay Puri,Robert Krasucki,Jacob Lawrence,Digby Quested,Nicholas Bass,Caroline Crombie,Gillian Fraser,Soh Leh Kuan,Nicholas Walker,Kevin A. McGhee,Ben S. Pickard,P. Malloy,Alan W Maclean,Margaret Van Beck,Michele T. Pato,Helena Medeiros,Frank A. Middleton,Célia Barreto Carvalho,Christopher P. Morley,Ayman H. Fanous,David V. Conti,James A. Knowles,Carlos Ferreira,António Macedo,M. Helena Azevedo,Andrew Kirby,Andrew Kirby,Manuel A. R. Ferreira,Manuel A. R. Ferreira,Mark J. Daly,Mark J. Daly,Kimberly Chambert,Finny G Kuruvilla,Stacey Gabriel,Kristin G. Ardlie,Jennifer L. Moran +81 more
TL;DR: The extent to which common genetic variation underlies the risk of schizophrenia is shown, using two analytic approaches, and the major histocompatibility complex is implicate, which is shown to involve thousands of common alleles of very small effect.
Journal ArticleDOI
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
S. Hong Lee,Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Stephen V. Faraone,Shaun Purcell,Shaun Purcell,Shaun Purcell,Roy H. Perlis,Roy H. Perlis,Bryan J. Mowry,Bryan J. Mowry,Anita Thapar,Michael E. Goddard,John S. Witte,Devin Absher,Ingrid Agartz,Huda Akil,Farooq Amin,Ole A. Andreassen,Adebayo Anjorin,Richard Anney,Verneri Anttila,Dan E. Arking,Philip Asherson,Maria Helena Pinto de Azevedo,Lena Backlund,Judith A. Badner,Anthony J. Bailey,Tobias Banaschewski,Jack D. Barchas,Michael R. Barnes,Thomas B. Barrett,Nicholas Bass,Agatino Battaglia,Michael Bauer,Mònica Bayés,Frank Bellivier,Sarah E. Bergen,Sarah E. Bergen,Sarah E. Bergen,Wade H. Berrettini,Catalina Betancur,Catalina Betancur,Catalina Betancur,Thomas Bettecken,Joseph Biederman,Elisabeth B. Binder,Donald W. Black,Douglas Blackwood,Cinnamon S. Bloss,Michael Boehnke,Dorret I. Boomsma,Gerome Breen,Gerome Breen,René Breuer,Richard Bruggeman,Paul Cormican,Nancy G. Buccola,Jan K. Buitelaar,William E. Bunney,Joseph D. Buxbaum,William Byerley,Enda M. Byrne,Sian Caesar,Wiepke Cahn,Rita M. Cantor,Miguel Casas,Aravinda Chakravarti,Kimberly Chambert,Khalid Choudhury,Sven Cichon,Sven Cichon,C. Robert Cloninger,David A. Collier,Edwin H. Cook,Hilary Coon,Bru Cormand,Aiden Corvin,William Coryell,David Craig,Ian W. Craig,Jennifer Crosbie,Michael L. Cuccaro,David Curtis,Darina Czamara,Susmita Datta,Geraldine Dawson,Richard O. Day,Eco J. C. de Geus,Franziska Degenhardt,Srdjan Djurovic,Gary Donohoe,Alysa E. Doyle,Jubao Duan,Frank Dudbridge,Eftichia Duketis,Richard P. Ebstein,Howard J. Edenberg,Josephine Elia,Sean Ennis,Bruno Etain,Ayman H. Fanous,Ayman H. Fanous,Anne Farmer,I. Nicol Ferrier,Matthew Flickinger,Eric Fombonne,Tatiana Foroud,Josef Frank,Barbara Franke,Christine Fraser,Robert Freedman,Nelson B. Freimer,Christine M. Freitag,Marion Friedl,Louise Frisén,Louise Gallagher,Pablo V. Gejman,Lyudmila Georgieva,Elliot S. Gershon,Daniel H. Geschwind,Ina Giegling,Michael Gill,Scott D. Gordon,Katherine Gordon-Smith,Katherine Gordon-Smith,Elaine K. Green,Tiffany A. Greenwood,Dorothy E. Grice,Magdalena Gross,Detelina Grozeva,Weihua Guan,Weihua Guan,Hugh Gurling,Lieuwe de Haan,Jonathan L. Haines,Hakon Hakonarson,Joachim Hallmayer,Steven P. Hamilton,Marian L. Hamshere,Thomas Hansen,Annette M. Hartmann,Martin Hautzinger,Andrew C. Heath,Anjali K. Henders,Stefan Herms,Stefan Herms,Ian B. Hickie,Maria Hipolito,Susanne Hoefels,Peter Holmans,Florian Holsboer,Witte J.G. Hoogendijk,Jouke-Jan Hottenga,Christina M. Hultman,Vanessa Hus,Andres Ingason,Marcus Ising,Stéphane Jamain,Edward G. Jones,Ian Jones,Lisa Jones,Jung-Ying Tzeng,Anna K. Kähler,René S. Kahn,Radhika Kandaswamy,Matthew C. Keller,James L. Kennedy,Elaine Kenny,Lindsey Kent,Yunjung Kim,George Kirov,Sabine M. Klauck,Lambertus Klei,James A. Knowles,Martin A. Kohli,Daniel L. Koller,Bettina Konte,Ania Korszun,Lydia Krabbendam,Robert Krasucki,Jonna Kuntsi,Phoenix Kwan,Mikael Landén,Mikael Landén,Niklas Långström,Mark Lathrop,Jacob Lawrence,William Lawson,Marion Leboyer,David H. Ledbetter,Phil Lee,Todd Lencz,Todd Lencz,Klaus-Peter Lesch,Klaus-Peter Lesch,Douglas F. Levinson,Cathryn M. Lewis,Jun Li,Paul Lichtenstein,Jeffrey A. Lieberman,Danyu Lin,Don H. Linszen,Chunyu Liu,Falk W. Lohoff,Sandra K. Loo,Catherine Lord,Jennifer K. Lowe,Susanne Lucae,Donald J. MacIntyre,Pamela A. F. Madden,Elena Maestrini,Patrik K. E. Magnusson,Pamela B. Mahon,Wolfgang Maier,Anil K. Malhotra,Anil K. Malhotra,Shrikant Mane,Christa Lese Martin,Nicholas G. Martin,Manuel Mattheisen,Manuel Mattheisen,Keith Matthews,Morten Mattingsdal,Steven A. McCarroll,Kevin A. McGhee,James J. McGough,Patrick J. McGrath,Peter McGuffin,Melvin G. McInnis,Andrew M. McIntosh,Rebecca McKinney,Alan W. McLean,Francis J. McMahon,William M. McMahon,Andrew McQuillin,Helena Medeiros,Sarah E. Medland,Sandra Meier,Ingrid Melle,Fan Meng,Jobst Meyer,Christel M. Middeldorp,Lefkos T. Middleton,Vihra Milanova,Ana Miranda,Anthony P. Monaco,Anthony P. Monaco,Grant W. Montgomery,Jennifer L. Moran,Daniel Moreno-De-Luca,Gunnar Morken,Derek W. Morris,Eric M. Morrow,Valentina Moskvina,Pierandrea Muglia,Thomas W. Mühleisen,Walter J. Muir,Bertram Müller-Myhsok,Michael T. Murtha,Richard M. Myers,Inez Myin-Germeys,Michael C. Neale,Stan F. Nelson,Caroline M. Nievergelt,Ivan Nikolov,Vishwajit L. Nimgaonkar,Willem A. Nolen,Markus M. Nöthen,John I. Nurnberger,Evaristus A. Nwulia,Dale R. Nyholt,Colm O'Dushlaine,Robert D. Oades,Ann Olincy,Guiomar Oliveira,Line Olsen,Roel A. Ophoff,Roel A. Ophoff,Urban Ösby,Michael John Owen,Aarno Palotie,Jeremy R. Parr,Andrew D. Paterson,Carlos N. Pato,Michele T. Pato,Brenda W.J.H. Penninx,Michele L. Pergadia,Margaret A. Pericak-Vance,Benjamin S. Pickard,Jonathan Pimm,Joseph Piven,Danielle Posthuma,Danielle Posthuma,James B. Potash,Fritz Poustka,Peter Propping,Vinay Puri,Digby Quested,Emma M. Quinn,Josep Antoni Ramos-Quiroga,Henrik B. Rasmussen,Soumya Raychaudhuri,Soumya Raychaudhuri,Karola Rehnström,Andreas Reif,Marta Ribasés,John P. Rice,Marcella Rietschel,Kathryn Roeder,Herbert Roeyers,Lizzy Rossin,Aribert Rothenberger,Guy A. Rouleau,Douglas M. Ruderfer,Dan Rujescu,Alan R. Sanders,Stephen Sanders,Susan L. Santangelo,Susan L. Santangelo,Joseph A. Sergeant,Russell Schachar,Martin Schalling,Alan F. Schatzberg,William A. Scheftner,Gerard D. Schellenberg,Stephen W. Scherer,Nicholas J. Schork,Thomas G. Schulze,Thomas G. Schulze,Johannes Schumacher,Markus J. Schwarz,Edward M. Scolnick,Laura J. Scott,Jianxin Shi,Paul D. Shilling,Stanley I. Shyn,Jeremy M. Silverman,Susan L. Slager,Susan L. Smalley,Johannes H. Smit,Erin N. Smith,Edmund J.S. Sonuga-Barke,Edmund J.S. Sonuga-Barke,David St Clair,Matthew W. State,Michael Steffens,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,John Strauss,Jana Strohmaier,T. Scott Stroup,James S. Sutcliffe,Peter Szatmari,Szabocls Szelinger,Srinivasa Thirumalai,Robert C. Thompson,Alexandre A. Todorov,Federica Tozzi,Jens Treutlein,Manfred Uhr,Edwin J. C. G. van den Oord,Gerard van Grootheest,Jim van Os,Astrid M. Vicente,Astrid M. Vicente,Astrid M. Vicente,Veronica J. Vieland,John B. Vincent,Peter M. Visscher,Christopher A. Walsh,Thomas H. Wassink,Stanley J. Watson,Myrna M. Weissman,Thomas Werge,Thomas F. Wienker,Ellen M. Wijsman,Gonneke Willemsen,Nigel Williams,A. Jeremy Willsey,Stephanie H. Witt,Wei Xu,Allan H. Young,Allan H. Young,Timothy W. Yu,Stanley Zammit,Peter P. Zandi,Peng Zhang,Frans G. Zitman,Sebastian Zöllner,Bernie Devlin,John R. Kelsoe,John R. Kelsoe,Pamela Sklar,Mark J. Daly,Mark J. Daly,Michael Conlon O'Donovan,Nicholas John Craddock,Patrick F. Sullivan,Jordan W. Smoller,Jordan W. Smoller,Kenneth S. Kendler,Naomi R. Wray +405 more
TL;DR: Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Journal ArticleDOI
Genome-wide association study identifies five new schizophrenia loci
Stephan Ripke,Alan R. Sanders,Kenneth S. Kendler,Douglas F. Levinson,Pamela Sklar,Pamela Sklar,Peter Holmans,Danyu Lin,Jubao Duan,Roel A. Ophoff,Roel A. Ophoff,Ole A. Andreassen,Edward M. Scolnick,Sven Cichon,David St Clair,Aiden Corvin,Hugh Gurling,Thomas Werge,Dan Rujescu,Douglas Blackwood,Carlos N. Pato,Anil K. Malhotra,Anil K. Malhotra,Shaun Purcell,Frank Dudbridge,Benjamin M. Neale,Lizzy Rossin,Peter M. Visscher,Danielle Posthuma,Douglas M. Ruderfer,Ayman H. Fanous,Ayman H. Fanous,Ayman H. Fanous,Hreinn Stefansson,Stacy Steinberg,Bryan J. Mowry,Vera Golimbet,Marc De Hert,Erik G. Jönsson,István Bitter,Olli Pietiläinen,David A. Collier,Sarah Tosato,Ingrid Agartz,Margot Albus,Madeline Alexander,Richard Amdur,Richard Amdur,Farooq Amin,Farooq Amin,Nicholas Bass,Sarah E. Bergen,Donald W. Black,Anders D. Børglum,Matthew A. Brown,Richard Bruggeman,Nancy G. Buccola,William Byerley,Wiepke Cahn,Rita M. Cantor,Vaughan J. Carr,Stanley V. Catts,Khalid Choudhury,C. Robert Cloninger,Paul Cormican,Nicholas John Craddock,Patrick Danoy,Susmita Datta,Lieuwe de Haan,Ditte Demontis,Dimitris Dikeos,Srdjan Djurovic,Peter Donnelly,Gary Donohoe,L. Duong,Sarah Dwyer,Anders Fink-Jensen,Robert Freedman,Nelson B. Freimer,Marion Friedl,Lyudmila Georgieva,Ina Giegling,Michael Gill,Birte Glenthøj,Stephanie Godard,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Annette M. Hartmann,Frans Henskens,David M. Hougaard,Christina M. Hultman,Andres Ingason,Assen Jablensky,Klaus D. Jakobsen,M. Jay,Gesche Jürgens,René S. Kahn,Matthew C. Keller,Gunter Kenis,Elaine Kenny,Yunjung Kim,George Kirov,H. Konnerth,Bettina Konte,Lydia Krabbendam,Robert Krasucki,Virginia K. Lasseter,Claudine Laurent,Jacob Lawrence,Todd Lencz,Todd Lencz,F. Bernard Lerer,Kung Yee Liang,Paul Lichtenstein,Jeffrey A. Lieberman,Don H. Linszen,Jouko Lönnqvist,Carmel M. Loughland,Alan W Maclean,Brion S. Maher,Wolfgang Maier,J. Mallet,P. Malloy,Manuel Mattheisen,Morten Mattingsdal,Kevin A. McGhee,John J. McGrath,Andrew M. McIntosh,Duncan E. McLean,Andrew McQuillin,Ingrid Melle,Patricia T. Michie,Vihra Milanova,Derek W. Morris,Ole Mors,Preben Bo Mortensen,Valentina Moskvina,Pierandrea Muglia,Inez Myin-Germeys,Deborah A. Nertney,Gerald Nestadt,Jimmi Nielsen,Ivan Nikolov,Merete Nordentoft,Nadine Norton,Markus M. Nöthen,Colm O'Dushlaine,Ann Olincy,Line Olsen,F. Anthony O'Neill,Torben F. Ørntoft,Michael John Owen,Christos Pantelis,George N. Papadimitriou,Michele T. Pato,Leena Peltonen,Leena Peltonen,Hannes Petursson,Ben S. Pickard,Jonathan Pimm,Ann E. Pulver,Vinay Puri,Digby Quested,Emma M. Quinn,Henrik B. Rasmussen,János Réthelyi,R. Ribble,Marcella Rietschel,Marcella Rietschel,Brien P. Riley,Mirella Ruggeri,Ulrich Schall,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Sibylle G. Schwab,Rodney J. Scott,Jianxin Shi,Engilbert Sigurdsson,Jeremy M. Silverman,Jeremy M. Silverman,Chris C. A. Spencer,Kari Stefansson,Amy Strange,Eric Strengman,T. Scott Stroup,Jaana Suvisaari,Lars Terenius,Srinivasa Thirumalai,Johan H. Thygesen,Sally Timm,Draga Toncheva,Edwin J. C. G. van den Oord,Jim van Os,Ruud van Winkel,Ruud van Winkel,Jan H. Veldink,Dermot Walsh,August G. Wang,Durk Wiersma,Dieter B. Wildenauer,Hywel Williams,Nigel Williams,Brandon Wormley,Stan Zammit,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan,Mark J. Daly,Pablo V. Gejman +210 more
TL;DR: The authors examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects.
Journal ArticleDOI
De novo mutations in schizophrenia implicate synaptic networks
Menachem Fromer,Andrew Pocklington,David J. Kavanagh,Hywel Williams,Sarah Dwyer,Padhraig Gormley,Lyudmila Georgieva,Elliott Rees,Priit Palta,Douglas M. Ruderfer,Noa Carrera,Isla Humphreys,Jessica S. Johnson,Panos Roussos,Douglas Barker,Eric Banks,Vihra Milanova,Seth G. N. Grant,Eilis Hannon,Samuel A. Rose,Kimberly Chambert,Milind Mahajan,Edward M. Scolnick,Jennifer L. Moran,George Kirov,Aarno Palotie,Steven A. McCarroll,Peter Holmans,Pamela Sklar,Michael John Owen,Shaun Purcell,Michael Conlon O'Donovan +31 more
TL;DR: Genes affected by mutations in schizophrenia overlap those mutated in autism and intellectual disability, as do mutation-enriched synaptic pathways, and pathophysiology shared with other neurodevelopmental disorders.