Ford Motor Company

About: Ford Motor Company is a company organization based out in Dearborn, Michigan, United States. It is known for research contribution in the topics: Internal combustion engine & Signal. The organization has 36123 authors who have published 51450 publications receiving 855200 citations. The organization is also known as: Ford Motor & Ford Motor Corporation.

Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells

Abstract: The long-term (4-month) responses to treatment of stroke in the older adult rat, using rat bone marrow stromal cells (MSCs), have not been investigated. Retired breeder rats were subjected to middle cerebral artery occlusion (MCAo) alone, or injected intravenously with 3 x 10(6) MSCs, at 7 days after MCAo. Functional recovery was measured using an adhesive-removal patch test and a modified neurological severity score. Bromodeoxyuridine, a cell proliferation marker, was injected daily for 14 before sacrifice. Animals were sacrificed 4 months after stroke. Double immunostaining was used to identify cell proliferation and cell types for axons, astrocytes, microglia, and oligodendrocytes. MSC treatment induced significant improvement in neurological outcome after MCAo compared with control rats. MSC treatment reduced the thickness of the scar wall (P < 0.05) and reduced the numbers of microglia/macrophages within the scar wall (P < 0.01). Double staining showed increased expression of an axonal marker (GAP-43), among reactive astrocytes in the scar boundary zone and in the subventricular zone in the treated rats. Bromodeoxyuridine in cells preferentially colocalized with markers of astrocytes (GFAP) and oligodendrocytes (RIP) in the ipsilateral hemisphere, and gliogenesis was enhanced in the subventricular zone of the rats treated with MSCs. This is the first report to show that MSCs injected at 7 days after stroke improve long-term neurological outcome in older animals. Brain tissue repair is an ongoing process with reactive gliosis, which persists for at least 4 months after stroke. Reactive astrocytes responding to MSC treatment of ischemia may also promote axonal regeneration during long-term recovery.

Anti‐ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat

Abstract: Intercellular adhesion molecule-1 (ICAM-1) is a glycoprotein expressed on endothelial cells that facilitates leukocyte adhesion. To test the hypothesis that reduction of leukocytes in an ischemic lesion reduces ischemic brain damage, we measured the effect of administration of an anti-ICAM-1 monoclonal antibody on ischemic brain damage after transient middle cerebral artery occlusion in the rat. ICAM-1 expression increased in the ischemic lesion, and the lesion volume was significantly reduced by 41% in the anti-ICAM-1 antibody group compared with the control group (p < 0.05). Numbers of polymorphonuclear leukocytes (PMNs) were significantly reduced in the cortices of the anti-ICAM-1 antibody group compared with the control animals (p < 0.05). Our data indicate that administration of anti-ICAM-1 antibody results in a significant reduction of ischemic brain damage concomitant with a reduction of PMNs in the lesion after transient focal cerebral ischemia in the rat.

Magnetorheological elastomers : Properties and applications

Abstract: Magnetorhelogical (MR) elastomers are viscoelastic solids whose mechanical properties are controllable by applied magnetic fields. We have developed a family of MR elastomers, comprising micrometer-sized carbonyl iron particles embedded in natural rubber, that can be processed using conventional rubber-mixing techniques. By crosslinking the elastomer in the presence of an applied magnetic field, field-induced interparticle interactions promote the formation of particle chains and columns aligned along the field direction. The resulting composites possess field- dependent of the mechanical properties of MR elastometers enables the construction of controllable elastomeric components, such as suspension bushings, that may prove advantageous in some automotive applications.

Many-Objective optimization: an engineering design perspective

Abstract: Evolutionary multicriteria optimization has traditionally concentrated on problems comprising 2 or 3 objectives. While engineering design problems can often be conveniently formulated as multiobjective optimization problems, these often comprise a relatively large number of objectives. Such problems pose new challenges for algorithm design, visualisation and implementation. Each of these three topics is addressed. Progressive articulation of design preferences is demonstrated to assist in reducing the region of interest for the search and, thereby, simplified the problem. Parallel coordinates have proved a useful tool for visualising many objectives in a two-dimensional graph and the computational grid and wireless Personal Digital Assistants offer technological solutions to implementation difficulties arising in complex system design.

On Sequential Sampling for Global Metamodeling in Engineering Design

Abstract: Approximation models (also known as metamodels) have been widely used in engineering design to facilitate analysis and optimization of complex systems that involve computationally expensive simulation programs. The accuracy of metamodels is directly related to the sampling strategies used. Our goal in this paper is to investigate the general applicability of sequential sampling for creating global metamodels. Various sequential sampling approaches are reviewed and new approaches are proposed. The performances of these approaches are investigated against that of the one-stage approach using a set of test problems with a variety of features. The potential usages of sequential sampling strategies are also discussed.Copyright © 2002 by ASME