Open Access
A global reference for human genetic variation
Adam Auton,Gonçalo R. Abecasis,David Altshuler,Richard Durbin,David R. Bentley,Aravinda Chakravarti,Andrew G. Clark,Peter Donnelly,Evan E. Eichler,Paul Flicek,Stacey Gabriel,Richard A. Gibbs,Eric D. Green,Matthew E. Hurles,Bartha Maria Knoppers,Jan O. Korbel,Eric S. Lander,Charles Kai-Wu Lee,Hans Lehrach,Elaine R. Mardis,Gabor T. Marth,Gil McVean,Deborah A. Nickerson,Jeanette Schmidt,Stephen T. Sherry,Jun Wang,Richard K. Wilson,Eric Boerwinkle,Harsha Doddapaneni,Yi Han,Viktoriya Korchina,Christie Kovar,Sandra J. Lee,Donna M. Muzny,Jeffrey G. Reid,Yiming Zhu,Yuqi Chang,Qiang Feng,Xiaodong Fang,Xiaosen Guo,Min Jian,Hui Jiang,Xin Jin,Tianming Lan,Guoqing Li,Jingxiang Li,Yingrui Li,Shengmao Liu,Xiao Liu,Yao Lu,Xuedi Ma,Meifang Tang,Bo Wang,Guangbiao Wang,Honglong Wu,Renhua Wu,Xun Xu,Ye Yin,Dandan Zhang,Wenwei Zhang,Jiao Zhao,Meiru Zhao,Xiaole Zheng,Namrata Gupta,Neda Gharani,Lorraine Toji,Norman P. Gerry,Alissa M. Resch,Jonathan Barker,Laura Clarke,Laurent Gil,Sarah E. Hunt,Gavin Kelman,Eugene Kulesha,Rasko Leinonen,William M. McLaren,Rajesh Radhakrishnan,Asier Roa,Dmitriy Smirnov,Richard Smith,Ian Streeter,Anja Thormann,Iliana Toneva,Brendan Vaughan,Xiangqun Zheng-Bradley,Russell J. Grocock,Sean Humphray,Terena James,Zoya Kingsbury,Ralf Sudbrak,M. Albrecht,Vyacheslav Amstislavskiy,Tatiana A. Borodina,Matthias Lienhard,Florian Mertes,Marc Sultan,Bernd Timmermann,Marie-Laure Yaspo,Lucinda Fulton,Robert S. Fulton,Victor Ananiev,Zinaida Belaia,Dimitriy Beloslyudtsev,Nathan Bouk,Chao Chen,Deanna M. Church,Robert M. Cohen,Charles Cook,John Garner,Timothy Hefferon,Mikhail Kimelman,Chunlei Liu,John Lopez,Peter Meric,Chris O’Sullivan,Yuri Ostapchuk,Lon Phan,Sergiy Ponomarov,Valerie A. Schneider,Eugene Shekhtman,Karl Sirotkin,Douglas J. Slotta,Hua Zhang,Senduran Balasubramaniam,John Burton,Petr Danecek,Thomas M. Keane,Anja Kolb-Kokocinski,Shane A. McCarthy,James Stalker,Michael A. Quail,Christopher Davies,Jeremy Gollub,Teresa Webster,Brant Wong,Yiping Zhan,Christopher L. Campbell,Yu Kong,Anthony Marcketta,Fuli Yu,Lilian Antunes,Matthew N. Bainbridge,Aniko Sabo,Zhuoyi Huang,Lachlan J. M. Coin,Lin Fang,Qibin Li,Zhenyu Li,Haoxiang Lin,Binghang Liu,Ruibang Luo,Haojing Shao,Yinlong Xie,Chen Ye,Chang Yu,Fan Zhang,Hancheng Zheng,Hongmei Zhu,Can Alkan,Elif Dal,Fatma Kahveci,Erik Garrison,Deniz Kural,Wan-Ping Lee,Wen Fung Leong,Michael Strömberg,Alistair Ward,Jiantao Wu,Mengyao Zhang,Mark J. Daly,Mark A. DePristo,Robert E. Handsaker,Eric Banks,Gaurav Bhatia,Guillermo del Angel,Giulio Genovese,Heng Li,Seva Kashin,Steven A. McCarroll,James Nemesh,Ryan Poplin,Seungtai Yoon,Jayon Lihm,Vladimir Makarov,Srikanth Gottipati,Alon Keinan,Juan L. Rodriguez-Flores,Tobias Rausch,Markus Hsi-Yang Fritz,Adrian M. Stütz,Kathryn Beal,Avik Datta,Javier Herrero,Graham R. S. Ritchie,Daniel R. Zerbino,Pardis C. Sabeti,Ilya Shlyakhter,Stephen F. Schaffner,Joseph J. Vitti,David Neil Cooper,Edward V. Ball,Peter D. Stenson,Bret Barnes,Markus J. Bauer,R. Keira Cheetham,Anthony J. Cox,Michael A. Eberle,Scott Kahn,Lisa Murray,John F. Peden,Richard Shaw,Eimear E. Kenny,Mark A. Batzer,Miriam K. Konkel,Jerilyn A. Walker,Daniel G. MacArthur,Monkol Lek,Ralf Herwig,Li Ding,Daniel C. Koboldt,David E. Larson,Kai Ye,Simon Gravel,Anand Swaroop,Emily Y. Chew,Tuuli Lappalainen,Yaniv Erlich,Melissa Gymrek,Thomas Willems,Jared T. Simpson,Mark D. Shriver,Jeffrey A. Rosenfeld,Carlos Bustamante,Stephen B. Montgomery,Francisco M. De La Vega,Jake K. Byrnes,Andrew Carroll,Marianne K. DeGorter,Phil Lacroute,Brian K. Maples,Alicia R. Martin,Andrés Moreno-Estrada,Suyash Shringarpure,Fouad Zakharia,Eran Halperin,Yael Baran,Eliza Cerveira,Jaeho Hwang,Ankit Malhotra,Dariusz Plewczynski,Kamen Radew,Mallory Romanovitch,Chengsheng Zhang,Fiona Hyland,David Craig,Alexis Christoforides,Nils Homer,Tyler Izatt,Ahmet Kurdoglu,Shripad Sinari,Kevin Squire,Chunlin Xiao,Jonathan Sebat,Danny Antaki,Madhusudan Gujral,Amina Noor,Kenny Ye,Esteban G. Burchard,Ryan D. Hernandez,Christopher R. Gignoux,David Haussler,Sol Katzman,W. James Kent,Bryan Howie,Andres Ruiz-Linares,Emmanouil T. Dermitzakis,Scott E. Devine,Hyun Min Kang,Jeffrey M. Kidd,Thomas W. Blackwell,Sean Caron,Wei Chen,S. Emery,Lars G. Fritsche,Christian Fuchsberger,Goo Jun,Bingshan Li,R. P. Lyons,Chris Scheller,Carlo Sidore,Shiya Song,Elzbieta Sliwerska,Daniel Taliun,Adrian Tan,Ryan P. Welch,Mary Kate Wing,Xiaowei Zhan,Philip Awadalla,Alan Hodgkinson,Yun Li,Xinghua Shi,Andrew Quitadamo,Gerton Lunter,Jonathan Marchini,Simon Myers,Claire Churchhouse,Olivier Delaneau,Anjali Gupta-Hinch,Warren W. Kretzschmar,Zamin Iqbal,Iain Mathieson,Androniki Menelaou,Andrew J. Rimmer,Dionysia K. Xifara,Taras K. Oleksyk,Yunxin Fu,Xiaoming Liu,Momiao Xiong,Lynn B. Jorde,David J. Witherspoon,Jinchuan Xing,Brian L. Browning,Sharon R. Browning,Fereydoun Hormozdiari,Peter H. Sudmant,Ekta Khurana,Chris Tyler-Smith,Cornelis A. Albers,Qasim Ayub,Yuan Chen,Vincenza Colonna,Luke Jostins,Klaudia Walter,Yali Xue,Mark Gerstein,Alexej Abyzov,Suganthi Balasubramanian,Jieming Chen,Declan Clarke,Yao Fu,Arif Harmanci,Mike Jin,Dong-Hoon Lee,Jeremy Liu,Xinmeng Jasmine Mu,Jing Zhang,Yan Zhang,Christopher Hartl,Khalid Shakir,Jeremiah D. Degenhardt,Sascha Meiers,Benjamin Raeder,Francesco Paolo Casale,Oliver Stegle,Eric-Wubbo Lameijer,Ira M. Hall,Vineet Bafna,Jacob J. Michaelson,Eugene J. Gardner,Ryan E. Mills,Gargi Dayama,Ken Chen,Xian Fan,Zechen Chong,Tenghui Chen,Mark Chaisson,John Huddleston,Maika Malig,Bradley J. Nelson,Nicholas F. Parrish,Ben Blackburne,Sarah J. Lindsay,Zemin Ning,Yujun Zhang,Hugo Y. K. Lam,Cristina Sisu,Danny Challis,Uday S. Evani,James T. Lu,Uma Nagaswamy,Jin Yu,Wangshen Li,Lukas Habegger,Haiyuan Yu,Fiona Cunningham,Ian Dunham,Kasper Lage,Jakob Berg Jespersen,Heiko Horn,Donghoon Kim,Rob DeSalle,Apurva Narechania,Melissa A. Wilson Sayres,Fernando L. Mendez,G. David Poznik,Peter A. Underhill,Lachlan Coin,David Mittelman,Ruby Banerjee,Maria Cerezo,Thomas W. Fitzgerald,Sandra Louzada,Andrea Massaia,Graham R S Ritchie,Fengtang Yang,Divya Kalra,Walker Hale,Xu Dan,Kathleen C. Barnes,Christine Beiswanger,Hongyu Cai,Hongzhi Cao,Brenna M. Henn,Danielle Jones,Jane Kaye,Alastair Kent,Angeliki Kerasidou,Rasika A. Mathias,Pilar N. Ossorio,Michael Parker,Charles N. Rotimi,Charmaine D.M. Royal,Karla Sandoval,Yeyang Su,Zhongming Tian,Sarah A. Tishkoff,Marc Via,Yuhong Wang,Huanming Yang,Ling Yang,Jiayong Zhu,Walter F. Bodmer,Gabriel Bedoya,Zhiming Cai,Yang Gao,Jiayou Chu,Leena Peltonen,Andrés C. García-Montero,Alberto Orfao,Julie Dutil,Juan Carlos Martínez-Cruzado,R. Mathias,Anselm Hennis,Harold Watson,Colin A. McKenzie,Firdausi Qadri,Regina C. LaRocque,Xiaoyan Deng,Danny Asogun,Onikepe A. Folarin,Christian T. Happi,Omonwunmi Omoniwa,Matt Stremlau,Ridhi Tariyal,Muminatou Jallow,Fatoumatta Sisay Joof,Tumani Corrah,Kirk A. Rockett,Dominic P. Kwiatkowski,Jaspal S. Kooner,Trâ`n Tịnh Hiê`n,Sarah J. Dunstan,Nguyen Thuy Hang,Richard Fonnie,Robert F. Garry,Lansana Kanneh,Lina M. Moses,John S. Schieffelin,Don Grant,Carla Gallo,Giovanni Poletti,Danish Saleheen,Asif Rasheed,Lisa D. Brooks,Adam Felsenfeld,Jean E. McEwen,Yekaterina Vaydylevich,Audrey Duncanson,Michael Dunn,Jeffery A. Schloss +479 more
TLDR
The 1000 Genomes Project as mentioned in this paper provided a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations, and reported the completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole genome sequencing, deep exome sequencing and dense microarray genotyping.Abstract:
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized a broad spectrum of genetic variation, in total over 88 million variants (84.7 million single nucleotide polymorphisms (SNPs), 3.6 million short insertions/deletions (indels), and 60,000 structural variants), all phased onto high-quality haplotypes. This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries. We describe the distribution of genetic variation across the global sample, and discuss the implications for common disease studies.read more
Citations
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Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.
Joana Damas,Graham M. Hughes,Kathleen C. Keough,Corrie A. Painter,Nicole S. Persky,Marco Corbo,Michael Hiller,Klaus-Peter Koepfli,Andreas R. Pfenning,Huabin Zhao,Huabin Zhao,Diane P. Genereux,Ross Swofford,Katherine S. Pollard,Oliver A. Ryder,Martin T. Nweeia,Martin T. Nweeia,Martin T. Nweeia,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Emma C. Teeling,Elinor K. Karlsson,Elinor K. Karlsson,Harris A. Lewin +23 more
TL;DR: A large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins are identified to assist the identification of intermediate hosts for Sars-Cov-2 and hence reduce the opportunity for a future outbreak of COVID-19.
Journal ArticleDOI
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Oded Kopper,Chris J. de Witte,Kadi Lõhmussaar,Jose Espejo Valle-Inclan,Nizar Hami,Lennart Kester,Anjali Vanita Balgobind,Jeroen Korving,Natalie Proost,Harry Begthel,Lise M van Wijk,Sonia Aristín Revilla,Rebecca Theeuwsen,Marieke van de Ven,Markus J. van Roosmalen,Bas Ponsioen,Victor W.H. Ho,Benjamin G. Neel,Tjalling Bosse,Katja N. Gaarenstroom,Harry Vrieling,Maaike P.G. Vreeswijk,Paul J. van Diest,Petronella O. Witteveen,Trudy N. Jonges,Johannes L. Bos,Alexander van Oudenaarden,Ronald P. Zweemer,Hugo J. Snippert,Wigard P. Kloosterman,Hans Clevers +30 more
TL;DR: A biobank of ovarian cancer organoids recapitulates the histopathological and molecular hallmarks of patient tumors and provides a resource for preclinical research and demonstrates their potential application for research and personalized medicine.
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Anubha Mahajan,Daniel Taliun,Matthias Thurner,Neil R. Robertson,Jason M. Torres,N. William Rayner,Anthony Payne,Valgerdur Steinthorsdottir,Robert A. Scott,Niels Grarup,James P. Cook,Ellen M. Schmidt,Matthias Wuttke,Chloé Sarnowski,Reedik Magill,Jana Nano,Christian Gieger,Stella Trompet,Cécile Lecoeur,Michael Preuss,Bram P. Prins,Xiuqing Guo,Lawrence F. Bielak,Jennifer E. Below,Donald W. Bowden,John C. Chambers,Young-Jin Kim,Maggie C.Y. Ng,Lauren E. Petty,Xueling Sim,Weihua Zhang,Amanda J. Bennett,Jette Bork-Jensen,Chad M. Brummett,Mickaël Canouil,Kai-Uwe Ec Kardt,Krista Fischer,Sharon L.R. Kardia,Florian Kronenberg,Kristi Läll,Ching-Ti Liu,Adam E. Locke,Jian'an Luan,Loanna Ntalla,Vibe Nylander,Sebastian Schoenherr,Claudia Schurmann,Loic Yengo,Erwin P. Bottinger,Ivan Brandslund,Cramer Christensen,George Dedoussis,Jose C. Florez,Ian Ford,Timothy M. Frayling,Vilmantas Giedraitis,Sophie Hackinger,Andrew T. Hattersley,Christian Herder,M. Arfan Ikram,Martin Ingelsson,Marit E. Jørgensen,Torben Jørgensen,Jennifer Kriebel,Johanna Kuusisto,Symen Ligthart,Cecilia M. Lindgren,Allan Linneberg,Valeriya Lyssenko,Vasiliki Mamakou,Thomas Meitinger,Karen L. Mohlke,Andrew D. Morris,Girish N. Nadkarni,James S. Pankow,Annette Peters,Naveed Sattar,Alena Stančáková,Konstantin Strauch,Kent D. Taylor,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Jaakko Tuomilehto,Daniel R. Witte,Josée Dupuis,Patricia A. Peyser,Eleftheria Zeggini,Ruth J. F. Loos,Philippe Froguel,Erik Ingelsson,Lars Lind,Leif Groop,Markku Laakso,Francis S. Collins,J. Wouter Jukema,Colin N. A. Palmer,Harald Grallert,Andres Metspalu,Abbas Dehghan,Anna Koettgen,Gonçalo R. Abecasis,James B. Meigs,Rotter, Jerome, I,Jonathan Marchini,Oluf Pedersen,Torben Hansen,Claudia Langenberg,Nicholas J. Wareham,Kari Stefansson,Anna L. Gloyn,Andrew P. Morris,Michael Boehnke,McCarthy, Mark, I +113 more
Abstract: We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).Combining 32 genome-wide association studies with high-density imputation provides a comprehensive view of the genetic contribution to type 2 diabetes in individuals of European ancestry with respect to locus discovery, causal-variant resolution, and mechanistic insight.
Journal ArticleDOI
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.
Miriam S. Udler,Jaegil Kim,Marcin von Grotthuss,Sílvia Bonàs-Guarch,Joanne B. Cole,Joanne B. Cole,Joshua Chiou,Michael Boehnke,Markku Laakso,Markku Laakso,Gil Atzmon,Benjamin Glaser,Josep M. Mercader,Kyle J. Gaulton,Kyle J. Gaulton,Jason Flannick,Gad Getz,Jose C. Florez +17 more
TL;DR: The approach identifies salient T2D genetically anchored and physiologically informed pathways, and supports the use of genetics to deconstruct T1D heterogeneity.
Journal ArticleDOI
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Caroline M. Nievergelt,Caroline M. Nievergelt,Adam X. Maihofer,Adam X. Maihofer,Torsten Klengel,Torsten Klengel,Elizabeth G. Atkinson,Elizabeth G. Atkinson,Chia-Yen Chen,Chia-Yen Chen,Karmel W. Choi,Karmel W. Choi,Jonathan R. I. Coleman,Shareefa Dalvie,Laramie E. Duncan,Joel Gelernter,Joel Gelernter,Daniel F. Levey,Daniel F. Levey,Mark W. Logue,Renato Polimanti,Renato Polimanti,Allison C. Provost,Andrew Ratanatharathorn,Murray B. Stein,Murray B. Stein,Katy Torres,Katy Torres,Allison E. Aiello,Lynn M. Almli,Ananda B. Amstadter,Søren Bo Andersen,Ole A. Andreassen,Paul A. Arbisi,Allison E. Ashley-Koch,S. Bryn Austin,Esmina Avdibegović,Dragan Babić,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Dewleen G. Baker,Dewleen G. Baker,Jean C. Beckham,Laura J. Bierut,Jonathan Ian Bisson,Marco P. Boks,Elizabeth A. Bolger,Anders D. Børglum,Anders D. Børglum,Bekh Bradley,Megan Brashear,Gerome Breen,Richard A. Bryant,A.C. Bustamante,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Joseph R. Calabrese,José Miguel Caldas de Almeida,Anders M. Dale,Mark J. Daly,Nikolaos P. Daskalakis,Jürgen Deckert,Douglas L. Delahanty,Michelle F. Dennis,Seth G. Disner,Katharina Domschke,Alma Dzubur-Kulenovic,Christopher R. Erbes,Alexandra Evans,Lindsay A. Farrer,Norah C. Feeny,Janine D. Flory,David Forbes,Carol E. Franz,Sandro Galea,Melanie E. Garrett,Bizu Gelaye,Elbert Geuze,Charles F. Gillespie,Aferdita Goci Uka,Scott D. Gordon,Guia Guffanti,Rasha Hammamieh,Supriya Harnal,Michael A. Hauser,Andrew C. Heath,Sian M. J. Hemmings,David M. Hougaard,David M. Hougaard,Miro Jakovljević,Marti Jett,Eric O. Johnson,Ian Jones,Tanja Jovanovic,Xue Jun Qin,Angela G. Junglen,Karen-Inge Karstoft,Milissa L. Kaufman,Ronald C. Kessler,Alaptagin Khan,Nathan A. Kimbrel,Anthony P. King,Nastassja Koen,Henry R. Kranzler,Henry R. Kranzler,William S. Kremen,William S. Kremen,Bruce R. Lawford,Lauren A.M. Lebois,Catrin Lewis,Sarah D. Linnstaedt,Adriana Lori,Bozo Lugonja,Jurjen J. Luykx,Michael J. Lyons,Jessica L. Maples-Keller,Charles R. Marmar,Alicia R. Martin,Alicia R. Martin,Nicholas G. Martin,Douglas Maurer,Matig R. Mavissakalian,Alexander C. McFarlane,Regina E. McGlinchey,Katie A. McLaughlin,Samuel A. McLean,Sarah McLeay,Divya Mehta,William P. Milberg,Mark W. Miller,Rajendra A. Morey,Charles P. Morris,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Benjamin M. Neale,Benjamin M. Neale,Elliot C. Nelson,Merete Nordentoft,Merete Nordentoft,Sonya B. Norman,Sonya B. Norman,Meaghan O'Donnell,Holly K. Orcutt,Matthew S. Panizzon,Edward S. Peters,Alan L. Peterson,Matthew Peverill,Robert H. Pietrzak,Robert H. Pietrzak,Melissa A. Polusny,John P. Rice,Stephan Ripke,Stephan Ripke,Stephan Ripke,Victoria B. Risbrough,Victoria B. Risbrough,Andrea L. Roberts,Alex O. Rothbaum,Barbara O. Rothbaum,Peter Roy-Byrne,Kenneth J. Ruggiero,Ariane Rung,Bart P. F. Rutten,Nancy L. Saccone,Sixto E. Sanchez,Dick Schijven,Soraya Seedat,Antonia V. Seligowski,Julia S. Seng,Christina M. Sheerin,Derrick Silove,Alicia K. Smith,Jordan W. Smoller,Jordan W. Smoller,Scott R. Sponheim,Dan J. Stein,Jennifer S. Stevens,Jennifer A. Sumner,Martin H. Teicher,Wesley K. Thompson,Edward J. Trapido,Monica Uddin,Robert J. Ursano,Leigh van den Heuvel,Miranda Van Hooff,Eric Vermetten,Christiaan H. Vinkers,Joanne Voisey,Yunpeng Wang,Yunpeng Wang,Zhewu Wang,Zhewu Wang,Thomas Werge,Thomas Werge,Michelle A. Williams,Douglas E. Williamson,Sherry Winternitz,Christiane Wolf,Erika J. Wolf,Jonathan D. Wolff,Rachel Yehuda,Rachel Yehuda,Ross McD. Young,Keith A. Young,Hongyu Zhao,Lori A. Zoellner,Israel Liberzon,Kerry J. Ressler,Kerry J. Ressler,Magali Haas,Karestan C. Koenen,Karestan C. Koenen +213 more
TL;DR: A GWAS from the Psychiatric Genomics Consortium is reported in which two risk loci in European ancestry and one locus in African ancestry individuals are identified and it is found that PTSD is genetically correlated with several other psychiatric traits.
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