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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders
Kiyofumi Yamakawa,Satoru Kamekura,Naohiro Kawamura,Masatomo Saegusa,Daisuke Kamei,Makoto Murakami,Ichiro Kudo,Satoshi Uematsu,Shizuo Akira,Ung-il Chung,Kozo Nakamura,Hiroshi Kawaguchi +11 more
TL;DR: In these mouse models of skeletal disorders, mPGES-1 was indispensable for bone repair through chondrocyte proliferation, but was not essential for the skeleton under normal physiologic conditions, nor did it play a role in the pathophysiologic conditions of bone loss due to ovariectomy, bone Loss due to unloading, or stress-induced OA.
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Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.
Takahisa Furuta,Takane Kikuchi,Takane Kikuchi,Shizuo Akira,Naohiro Watanabe,Yasuhiro Yoshikawa +5 more
TL;DR: It is demonstrated here for the first time that innate immune recognition by TLR4 is involved in protective mechanisms against peroral infection with T. gondii ME49, suggesting that the small intestine plays an important role in the induction of innate immunity in naturally acquired toxoplasmosis.
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Interleukin-18 regulates pathological intraocular neovascularization
Hong Qiao,Koh Hei Sonoda,Yasuhiro Ikeda,Takeru Yoshimura,Kuniaki Hijioka,Young Joon Jo,Yukio Sassa,Chikako Tsutsumi-Miyahara,Yasuaki Hata,Shizuo Akira,Tatsuro Ishibashi +10 more
TL;DR: It is concluded that IL‐18 regulates pathogenic retinal NV by promoting its regression rather than inhibiting its development, which suggests some useful, new approaches to treating retinopathy in humans.
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The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.
Alessandro Sessa,Ernesto Ciabatti,Daniela Drechsel,Luca Massimino,Gaia Colasante,Serena Giannelli,Takashi Satoh,Shizuo Akira,François Guillemot,Vania Broccoli +9 more
TL;DR: Global gene expression profiling combined with genome-wide binding site identification led to the identification of novel protein-protein interactions that control multiple features of INPs including cell-type identity, morphology, proliferation and migration dynamics.
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Commensal microbiota drive proliferation of conventional and Foxp3+ regulatory CD4+ T cells in mesenteric lymph nodes and Peyer’s patches
Sascha Cording,Diana Fleissner,Markus M. Heimesaat,Stefan Bereswill,Christoph Loddenkemper,Satoshi Uematsu,Shizuo Akira,Alf Hamann,Jochen Huehn +8 more
TL;DR: Commensal microbiota-derived stimuli support cycling of both conventional CD4(+) T cells and Foxp3(+) Tregs with TLR-mediated recognition of bacterial components not being the major mechanism controlling microbiota-driven T cell homeostasis.