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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Both IL‐12 and IL‐18 contribute to small intestinal Th1‐type immunopathology following oral infection with Toxoplasma gondii, but IL‐12 is dominant over IL‐18 in parasite control
Anna Vossenkämper,Daniela Struck,Cosme Alvarado-Esquivel,Tobias Went,Kioyshi Takeda,Shizuo Akira,Klaus Pfeffer,Gottfried Alber,Matthias Lochner,Irmgard Förster,Oliver Liesenfeld +10 more
TL;DR: Results reveal that both IL‐12 and IL‐18 play an important role in the development of intestinal immunopathology following oral infection with T. gondii, and neutralization ofIL‐18 (rather than TNF‐α, IL‐ 12, and IFN‐γ) may be a safe strategy for the treatment of Th1‐associated diseases.
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CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Regulates Osteoblast Differentiation
Ken Shirakawa,Shingo Maeda,Tomomi Gotoh,Makoto Hayashi,Kenichi Shinomiya,Shogo Ehata,Riko Nishimura,Masataka Mori,Kikuo Onozaki,Hidetoshi Hayashi,Satoshi Uematsu,Shizuo Akira,Etsuro Ogata,Kohei Miyazono,Takeshi Imamura +14 more
TL;DR: It is shown that C/EBP homologous protein (CHOP) is expressed in bone as well as in mesenchymal progenitors and primary osteoblasts and may have dual roles in regulating osteoblast differentiation and bone formation.
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Genetically Resistant Mice Lacking IL-18 Gene Develop Th1 Response and Control Cutaneous Leishmania major Infection
Gina M. Monteforte,Kiyoshi Takeda,Miriam Rodriguez-Sosa,Shizuo Akira,John R. David,Abhay R. Satoskar +5 more
TL;DR: The results indicate that despite the role IL-18 may play in early control of cutaneous L. major lesion growth, this cytokine is not critical for development of protective Th1 response and resolution of L.major infection.
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Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Masahiro Yamamoto,Shintaro Sato,Tatsuya Saitoh,Hiroaki Sakurai,Satoshi Uematsu,Taro Kawai,Ken Ishii,Osamu Takeuchi,Shizuo Akira +8 more
TL;DR: Ubc13 plays an important role in thymocyte TCR-mediated signaling and immune responses and PMA/ionophore-mediated ubiquitination of NF-κB essential modulator (NEMO)/IκB kinase γ (IKKγ) and phosphorylation of TGF-β-activated kinase 1 (TAK1) were nearly abolished in Ubc13-deficient thymocytes.
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Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation
Hisaaki Shinohara,Marcelo Behar,Marcelo Behar,Kentaro Inoue,Michio Hiroshima,Tomoharu Yasuda,Takeshi Nagashima,Shuhei Kimura,Hideki Sanjo,Shiori Maeda,Noriko Yumoto,Sewon Ki,Shizuo Akira,Yasushi Sako,Alexander Hoffmann,Alexander Hoffmann,Tomohiro Kurosaki,Mariko Okada-Hatakeyama +17 more
TL;DR: It is shown that the CARD-containing MAGUK protein 1 (CARMA1, also called CARD11)–TAK1 (MAP3K7)–inhibitor of NF-κB (IκB) kinase-β (IKKβ) module is a switch mechanism for NF-σκB activation in B cell receptor (BCR) signaling, and IKK activity is regulated by positive feedback from IKKβ to TAK1.