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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells.
Naohiko Shimada,Cevayir Coban,Yoichi Takeda,Masami Mizu,Jusaku Minari,Takahisa Anada,Yuichi Torii,Seiji Shinkai,Shizuo Akira,Ken Ishii,Kazuo Sakurai +10 more
TL;DR: Both in vivo and vitro assays indicated that the SPG complex may be of use for CpG DNA therapy, and it was suggested that unmodified SPG might effectively deliver PO in vivo due to the electrically neutral nature of un modified SPG.
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Toll-like receptor 2 (TLR2) and dectin-1 contribute to the production of IL-12p40 by bone marrow-derived dendritic cells infected with Penicillium marneffei.
Kiwamu Nakamura,Akiko Miyazato,Yoshinobu Koguchi,Yoshiyuki Adachi,Naohito Ohno,Shinobu Saijo,Yoichiro Iwakura,Kiyoshi Takeda,Shizuo Akira,Jiro Fujita,Keiko Ishii,Mitsuo Kaku,Kazuyoshi Kawakami +12 more
TL;DR: Results indicate that TLR2 and dectin-1 are essential in sensing P. marneffei for the activation of BM-DCs.
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Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin 6 Expression Via Toll-Like Receptor 2 Pathway in Mouse Adipocytes
Yasuko Abe,Akio Kawakami,Mizuko Osaka,Satoshi Uematsu,Shizuo Akira,Kentaro Shimokado,Frank M. Sacks,Masayuki Yoshida +7 more
TL;DR: ApoCIII may activate extracellular signal-regulated kinase and nuclear factor kB through TLR2 and induce proinflammatory adipokine expression in vitro and in vivo, which links dyslipidemia to inflammation in adipocytes, which, in turn, may contribute to atherosclerosis.
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In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model.
Hiroo Yokozeki,Minghua Wu,Koji Sumi,Sherif Awad,Takahiro Satoh,Ichiro Katayama,Kiyoshi Takeda,Shizuo Akira,Yasufumi Kaneda,Kiyoshi Nishioka +9 more
TL;DR: The first successful in vivo transfer of STAT6 decoy ODN to reduce the late-phase reaction is reported, thereby providing a new therapeutic strategy for AD.
Journal ArticleDOI
Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family.
Katsumi Toda,Shizuo Akira,Tadamitsu Kishimoto,Hiroshi Sasaki,Kozo Hashimoto,Yasutake Yamamoto,Yusuke Sagara,Yutaka Shizuta +7 more
TL;DR: The isolation of a cDNA encoding a DNA-binding protein which binds specifically to the regulatory element resulted in the disappearance of the transcriptional enhancing activity of the element, indicating that NF-IL6 is at least one of the nuclear factors which enhances transcription through binding to the cis-acting element.