S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.
Subhra K. Biswas,Pradeep Bist,Manprit Kaur Dhillon,Tasneem Kajiji,Carlos del Fresno,Masahiro Yamamoto,Eduardo López-Collazo,Shizuo Akira,Vinay Tergaonkar +8 more
TL;DR: Evidence is provided for a role of the TRIF/IFN-β pathway in the regulation of lipid A/TLR4-mediated endotoxin homotolerance and for the involvement of TRIF and IFN regulatory factor 3 deficiency in tolerance.
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Crohn disease: A current perspective on genetics, autophagy and immunity
Thaddeus S. Stappenbeck,John D. Rioux,Atsushi Mizoguchi,Tatsuya Saitoh,Alan Huett,Arlette Darfeuille-Michaud,Thomas Wileman,Noboru Mizushima,Simon R. Carding,Shizuo Akira,Miles Parkes,Ramnik J. Xavier +11 more
TL;DR: It is hoped that an improved understanding of pathogenic mechanisms, for example by studying the genetic basis of CD and other forms of inflammatory bowel diseases (IBD), will lead to improved therapies and possibly preventative strategies in individuals identified as being at risk.
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TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway *
Ryoko Yoshida,Giichi Takaesu,Giichi Takaesu,Hideyuki Yoshida,Fuyuki Okamoto,Tomoko Yoshioka,Yongwon Choi,Shizuo Akira,Taro Kawai,Akihiko Yoshimura,Akihiko Yoshimura,Takashi Kobayashi,Takashi Kobayashi +12 more
TL;DR: TRAF6 is demonstrated to be critical for IFN-α/β induction in response to viral infection and intracellular double-stranded RNA, poly(I:C), and data suggest that IPS-1 requires TRAF6 and MEKK1 to activate NF-κB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons.
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Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor.
Shogo Kurebayashi,Yoshihiro Miyashita,Takahisa Hirose,Soji Kasayama,Shizuo Akira,Tadamitsu Kishimoto +5 more
TL;DR: It is suggested that estrogens inhibit IL-6 production by interfering with the function ofNF-kappaB rather than that of NF-IL6, suggesting that E2-induced conformational change of the hormone binding domain plays an important role in protein-protein interaction between ER and NF- kappaB.
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ZIP Kinase Triggers Apoptosis from Nuclear PML Oncogenic Domains
TL;DR: It is shown that ZIPK is present in PODs, where it colocalizes with and binds to proapoptotic protein Daxx, and mediates a novel nuclear pathway for apoptosis.