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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
TLR9 Is Required for Protective Innate Immunity in Gram-Negative Bacterial Pneumonia: Role of Dendritic Cells
Urvashi Bhan,Nicholas W. Lukacs,John J. Osterholzer,Michael W. Newstead,Xianying Zeng,Thomas A. Moore,Tracy R. McMillan,Arthur M. Krieg,Shizuo Akira,Theodore J. Standiford +9 more
TL;DR: It is indicated that TLR 9 is required for effective innate immune responses against Gram-negative bacterial pathogens and that approaches to maximize TLR9-mediated DC responses may serve as a means to augment antibacterial immunity in pneumonia.
Journal ArticleDOI
The Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Requires the Ubiquitin-Conjugating Enzyme Ubc13 for NF-κB Activation
TL;DR: It is demonstrated that Tax polyubiquitin chains are composed predominantly of lysine 63-linked chains, and Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-κB activation.
Short Communication Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production
Simon B. Rasmussen,Søren B. Jensen,Christoffer Nielsen,Emanuel Quartin,Hiroki Kato,Zhijian J. Chen,Robert H. Silverman,Shizuo Akira,Søren R. Paludan +8 more
TL;DR: It is shown that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV).
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Toll-Like Receptor 2 Mediates Staphylococcus aureus–Induced Myocardial Dysfunction and Cytokine Production in the Heart
Pascal Knuefermann,Yasushi Sakata,J. Scott Baker,Chien-Hua Huang,Kenichi Sekiguchi,Hordur S. Hardarson,Osamu Takeuchi,Shizuo Akira,Jesus G. Vallejo +8 more
TL;DR: These results show for the first time that TLR2 signaling contributes to the loss of myocardial contractility and cytokine production in the heart during S aureus sepsis.
Journal ArticleDOI
Noninvasive detection of macrophage activation with single-cell resolution through machine learning
TL;DR: A method enabling the noninvasive study of minute cellular changes in response to stimuli, based on the acquisition of multiple parameters through label-free microscopy finds that morphological indicators are linked to the phenotype, which is mostly related to downstream effects, making the results obtained with these variables dose-dependent.