S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade
Min-Kyung Choo,Noritaka Kawasaki,Pattama Singhirunnusorn,Keiichi Koizumi,Shintaro Sato,Shizuo Akira,Ikuo Saiki,Hiroaki Sakurai +7 more
TL;DR: The results suggest that Taker1 plays a critical role for TRAIL-induced apoptosis, and the blockade of TAK1 kinase will improve the chances of overcoming cancer.
Journal ArticleDOI
Cytokine Signal Transduction through a Homo‐or Heterodimer of gp130
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Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
Carole Hénique,Guillaume Bollée,Guillaume Bollée,Guillaume Bollée,Xavier Loyer,Xavier Loyer,Florian Grahammer,Neeraj Dhaun,Neeraj Dhaun,Marine Camus,Julien Vernerey,Léa Guyonnet,Léa Guyonnet,François Gaillard,François Gaillard,Hélène Lazareth,Hélène Lazareth,Charlotte Meyer,Imane Bensaada,Imane Bensaada,Luc Legrès,Takashi Satoh,Shizuo Akira,Patrick Bruneval,Stefanie Dimmeler,Alain Tedgui,Alain Tedgui,Alexandre Karras,Eric Thervet,Dominique Nochy,Tobias B. Huber,Laurent Mesnard,Olivia Lenoir,Olivia Lenoir,Pierre-Louis Tharaux,Pierre-Louis Tharaux +35 more
TL;DR: It is demonstrated that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.
recognizes bacterial DNA
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Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response
Tatsuya Kozaki,Jun Komano,Daiki Kanbayashi,Michihiro Takahama,Michihiro Takahama,Takuma Misawa,Takashi Satoh,Osamu Takeuchi,Taro Kawai,Shigeomi Shimizu,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh +12 more
TL;DR: TIPARP is a viral RNA-sensing PRR that mediates antiviral responses triggered by BAX- and BAK1-dependent mitochondrial damage and typically localizes in the nucleus, but it accumulates in the cytoplasm after SINV infection, allowing targeting of cy toplasmic SinV RNA.