S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ
Masahiro Yamamoto,Soh Yamazaki,Satoshi Uematsu,Shintaro Sato,Hiroaki Hemmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hirotaka Kuwata,Osamu Takeuchi,Koichiro Takeshige,Tatsuya Saitoh,Shoji Yamaoka,Naoki Yamamoto,Shunsuke Yamamoto,Tatsushi Muta,Kiyoshi Takeda,Shizuo Akira +16 more
TL;DR: It is shown that IκBζ is indispensable for the expression of a subset of genes activated in TLR/IL-1R signalling pathways, including p50 subunit of NF-κB and endotoxin-induced expression of other genes such as Il12b and Csf2 is abrogated in Iκbζ-deficient macrophages.
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Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
Mathias Heikenwalder,Magdalini Polymenidou,Tobias Junt,Christina J. Sigurdson,Hermann Wagner,Shizuo Akira,Rolf M. Zinkernagel,Adriano Aguzzi +7 more
TL;DR: It is reported that daily injection of 60 μg CpG-ODN dramatically alters the morphology and functionality of mouse lymphoid organs and strongly reduced primary humoral immune responses and immunoglobulin class switching.
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Innate lymphoid cells regulate intestinal epithelial cell glycosylation
Yoshiyuki Goto,Takashi Obata,Jun Kunisawa,Shintaro Sato,Ivaylo I. Ivanov,Aayam Lamichhane,Natsumi Takeyama,Mariko Kamioka,Mitsuo Sakamoto,Takahiro Matsuki,Hiromi Setoyama,Akemi Imaoka,Satoshi Uematsu,Satoshi Uematsu,Shizuo Akira,Steven E. Domino,Paulina Kulig,Burkhard Becher,Jean-Christophe Renauld,Chihiro Sasakawa,Chihiro Sasakawa,Yoshinori Umesaki,Yoshimi Benno,Hiroshi Kiyono +23 more
TL;DR: It is shown that ILC3-mediated epithelial fucosylation protects the host from invasion of S. typhimurium into the intestine, and the critical role of the cytokines IL-22– and/or LT-producing I LC3 in the induction and regulation of intestinal epithelium fucOSylation is demonstrated.
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IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils
Tomohiro Yoshimoto,Hiroko Tsutsui,Kouji Tominaga,Katsuaki Hoshino,Haruki Okamura,Shizuo Akira,William E. Paul,Kenji Nakanishi +7 more
TL;DR: IL-18 has the potential to stimulate basophils but, when given with IL-12, exhibits an antiallergic action in vivo, and injection of IL-18 alone alone enhances basophil production ofIL-4 and histamine both in wild-type and IFN-gamma(-/-) mice.
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Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
Andreas Pichlmair,Andreas Pichlmair,Oliver Schulz,Choon-Ping Tan,Jan Rehwinkel,Hiroki Kato,Osamu Takeuchi,Shizuo Akira,Michael Way,Giampietro Schiavo,Caetano Reis e Sousa +10 more
TL;DR: An antibody to dsRNA is used to show that the presence of immunoreactivity in virus-infected cells does indeed correlate with the ability of RNA extracted from these cells to activate MDA5, and suggests that Mda5 activation requires an RNA web rather than simply long molecules of ds RNA.