S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
Mitsutoshi Yoneyama,Mika Kikuchi,Kanae Matsumoto,Tadaatsu Imaizumi,Makoto Miyagishi,Makoto Miyagishi,Kazunari Taira,Kazunari Taira,Eileen Foy,Yueh Ming Loo,Michael Gale,Shizuo Akira,Shin Yonehara,Atsushi Kato,Takashi Fujita +14 more
TL;DR: The results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors.
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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
Trude Helen Flo,Kelly D. Smith,Kelly D. Smith,Shintaro Sato,David J. Rodriguez,Margaret A. Holmes,Roland K. Strong,Shizuo Akira,Alan Aderem +8 more
TL;DR: This finding represents a new component of the innate immune system and the acute phase response to infection and limits bacterial growth by sequestrating the iron-laden siderophore.
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Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
TL;DR: This report examines how dectin-1, a lectin family receptor for β-glucans, collaborates with TLRs in recognizing microbes and demonstrates that collaborative recognition of distinct microbial components by different classes of innate immune receptors is crucial in orchestrating inflammatory responses.
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Autophagy in infection, inflammation and immunity
TL;DR: As discussed in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.
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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
Stefan Bauer,Carsten J. Kirschning,Hans Häcker,Vanessa Redecke,Susanne Hausmann,Shizuo Akira,Hermann Wagner,Grayson B. Lipford +7 more
TL;DR: It is shown that human TLR9 expression in human immune cells correlates with responsiveness to bacterial deoxycytidylate-phosphate-deoxyguanylate (CpG)-DNA, and data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating Cpg-DNA.