S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.
Nicolas Lapaque,Osamu Takeuchi,Fernando J. Corrales,Shizuo Akira,Ignacio Moriyón,Jonathan C. Howard,Jean-Pierre Gorvel +6 more
TL;DR: Observations show that different aspects of the LPS pathogen‐associated molecular pattern may be triggering different signalling pathways linked to the same TLR, and reinforce the hypothesis that non‐classical lipid As act as virulence factors by favouring the escape from the innate immune system.
Journal ArticleDOI
Signaling pathways activated by microorganisms
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: Invasion of viruses and bacteria is initially sensed by the host innate immune system, and evokes a rapid inflammatory response, and recent studies suggest that viral and bacterial DNA also induce interferons in a Toll-independent mechanism, possibly through unidentified cytoplasmic receptors.
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MyD88 Signaling Controls Autoimmune Myocarditis Induction
René R. Marty,Stephan Dirnhofer,Nora Mauermann,Sacha Schweikert,Shizuo Akira,Lukas Hunziker,Josef M. Penninger,Urs Eriksson +7 more
TL;DR: It is concluded that MyD88 might become a target for prevention of heart-specific autoimmunity and cardiomyopathy by repetitive injection of activated, MyHC-&agr;–loaded MyD87+/+ DCs that fully restored T-cell expansion and myocarditis in MyD 88−/− mice.
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Interleukin 6 activates heat-shock protein 90 beta gene expression.
Anastasis Stephanou,Vaksha Amin,David A. Isenberg,Shizuo Akira,T Kishimoto,David S. Latchman +5 more
TL;DR: It is shown that hsp90 protein accumulates to increased levels in both HuH7 hepatoma cells and peripheral blood mononuclear cells treated with IL-6, and the mechanism of its activation in patients with SLE is discussed.
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Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis.
TL;DR: Genetic and functional evidence is provided that ligand‐ and TLR‐specific stimuli synergize with SR‐A to mediate bacterial phagocytosis and are the first demonstration that subtle changes in the expression ofSR‐A and TLRs can substantially affect host bacterial clearance.