S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.
Christian A. Luber,Jürgen Cox,Henning Lauterbach,Ben Fancke,Matthias Selbach,Jürg Tschopp,Shizuo Akira,Marian Wiegand,Hubertus Hochrein,Meredith O'Keeffe,Matthias Mann +10 more
TL;DR: High-resolution mass spectrometry-based proteomics is used, combined with label-free quantitation algorithms, to determine the proteome of mouse splenic conventional and plasmacytoid DC subsets to a depth of 5,780 and 6,664 proteins, and found mutually exclusive expression of pattern recognition pathways not previously known to be different among conventional DC subset.
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The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.
Florian Heil,Parviz Ahmad-Nejad,Hiroaki Hemmi,Hubertus Hochrein,Franziska Ampenberger,Tanja Gellert,Harald Dietrich,Grayson B. Lipford,Kiyoshi Takeda,Shizuo Akira,Hermann Wagner,Stefan Bauer +11 more
TL;DR: It is concluded that TLR7, 8 and 9 form a functional subgroup within the TLR family that recognizes pathogen‐associated molecular patterns in endosomal/lysosomal compartments.
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MDA5/RIG-I and virus recognition.
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: Recently studies have suggested that TLRs are critical for activation of adaptive immune responses against several virus infections, although it may be premature to draw such a conclusion for virus infections in general.
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The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Nao Jounai,Fumihiko Takeshita,Kouji Kobiyama,Asako Sawano,Atsushi Miyawaki,Ke-Qin Xin,Ken Ishii,Taro Kawai,Shizuo Akira,Koichi Suzuki,Kenji Okuda +10 more
TL;DR: It is shown that the Atg5–Atg12 conjugate, a key regulator of the autophagic process, plays an important role in innate antiviral immune responses, thereby contributing to RNA virus replication in host cells.
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Endotoxin-induced maturation of MyD88-deficient dendritic cells.
TL;DR: The present study provides the first evidence that the MyD88-independent pathway downstrem of TLR4 can lead to functional DC maturation, which is critical for a link between innate and adaptive immunity.