S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.
TL;DR: It is shown that cisplatin and LPS act synergistically to produce nephrotoxicity which may involve proinflammatory cytokine production and urine, but not serum, TNF-alpha levels showed a synergistic increase by cisPlatin andLPS.
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CCAAT/Enhancer-binding Protein β Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4
Hiroyuki Tominaga,Shingo Maeda,Shingo Maeda,Makoto Hayashi,Shu Takeda,Shizuo Akira,Setsuro Komiya,Takashi Nakamura,Haruhiko Akiyama,Takeshi Imamura +9 more
TL;DR: Evidence is provided that C/EBPbeta is a crucial cofactor in the promotion of osteoblast maturation by Runx2 and ATF4, and the expression of type X collagen as well as chondrocyte hypertrophy were suppressed in mutant bone, providing new insight into the possible roles of C/ EBPbeta.
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The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes
Yoshinori Nagai,Toshihiko Kobayashi,Yuji Motoi,Kohtaroh Ishiguro,Sachiko Akashi,Shin-ichiroh Saitoh,Yutaka Kusumoto,Tsuneyasu Kaisho,Shizuo Akira,Mitsuru Matsumoto,Kiyoshi Takatsu,Kensuke Miyake +11 more
TL;DR: It is demonstrated that a signal via RP105 is uniquely important for regulating TLR-dependent Ab production to microbial membranes and down-regulated on germinal center cells.
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Stat3 in Resident Macrophages as a Repressor Protein of Inflammatory Response
Akihiro Matsukawa,Shinji Kudo,Takako Maeda,Kousuke Numata,Hiroyuki Watanabe,Kiyoshi Takeda,Shizuo Akira,Takaaki Ito +7 more
TL;DR: Evidence is provided that resident macrophages, but not other cell types, play a regulatory role in inflammation through a Stat3 signaling pathway, as demonstrated in a murine model of acute inflammation.