S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Suppression of allergic reaction by lambda-carrageenan: toll-like receptor 4/MyD88-dependent and -independent modulation of immunity.
Ryohei Tsuji,Katsuaki Hoshino,Y Noro,Noriko M. Tsuji,T Kurokawa,T Masuda,Shizuo Akira,Bernadeta Nowak +7 more
TL;DR: Background Recognition of foreign substances by innate immunity through pattern recognition receptors (PRRs) regulates acquired immunity such as allergic reaction.
Journal ArticleDOI
CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes.
Takahiro Sugiyama,Mayda Gursel,Fumihiko Takeshita,Cevayir Coban,Jacqueline Conover,Tsuneyasu Kaisho,Shizuo Akira,Dennis M. Klinman,Ken Ishii,Ken Ishii +9 more
TL;DR: The data suggest that CpG ORN represent a novel class of synthetic immunostimulatory nucleic acids with distinct target cells, receptors, and functions from that of previously known immunomodulatoryucleic acids.
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IL-12p40 and IL-18 in Crescentic Glomerulonephritis: IL-12p40 is the Key Th1-Defining Cytokine Chain, Whereas IL-18 Promotes Local Inflammation and Leukocyte Recruitment
A. Richard Kitching,Amanda L. Turner,Gabrielle R. Wilson,Timothy Semple,Dragana Odobasic,Jennifer R. Timoshanko,Kim M. O’Sullivan,Peter G. Tipping,Kiyoshi Takeda,Shizuo Akira,Stephen R. Holdsworth +10 more
TL;DR: It is demonstrated that in severe experimental crescentic GN, IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 has local proinflammatory roles.
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MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection
Sang Uk Seo,Hyung-Joon Kwon,Joo Hye Song,Young Ho Byun,Baik Lin Seong,Taro Kawai,Shizuo Akira,Mi Na Kweon +7 more
TL;DR: Results show that MyD88 signaling plays an important role for resisting primary influenza virus infection but is dispensable for protection against a secondary lethal challenge.
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Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-β Signaling Pathway
TL;DR: It is demonstrated that the IFN-β-mediated JAK/STAT pathway is essential for LPS or Escherichia coli-induced HMGB1 release, which is dependent on Toll/IL-1R domain-containing adapter-inducingIFN- β adaptor, and that NO acts as a downstream molecule of the IFn-β signaling.