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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Iκb Kinase α Is Essential for Mature B Cell Development and Function
Tsuneyasu Kaisho,Kiyoshi Takeda,Tohru Tsujimura,Taro Kawai,Fumiko Nomura,Nobuyuki Terada,Shizuo Akira +6 more
TL;DR: Results demonstrate that IKKα is critically involved in the prevention of cell death and functional development of mature B cells and transgene expression of bcl-2 could only partially rescue impaired B cell development in IKK α−/− chimeras.
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Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.
Jiefei Geng,Yasushi Ito,Linyu Shi,Palak Amin,Jiachen Chu,Amanda Tomie Ouchida,Adnan K. Mookhtiar,Heng Zhao,Daichao Xu,Bing Shan,Ayaz Najafov,Guangping Gao,Shizuo Akira,Junying Yuan,Junying Yuan +14 more
TL;DR: In this article, the authors show that TAK-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this critical decision.
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The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function.
Katsuaki Hoshino,Shin-ichiro Kashiwamura,Kozo Kuribayashi,Taku Kodama,Tohru Tsujimura,Kenji Nakanishi,Tomohiro Matsuyama,Kiyoshi Takeda,Shizuo Akira +8 more
TL;DR: It is shown that T1/ST2 does not play an essential role in development and function of Th2 cells and mast cells, and differentiation andfunction of bone marrow–derived cultured mast cells were unaffected.
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Cutting Edge: TLR2 Directly Triggers Th1 Effector Functions
TL;DR: This work identifies TLR2 as a new specific activator of Th1 cell function and implies the involvement in Th1-mediated responses, as well as identifying TLR functions and downstream signaling events in both effector T cells.
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Toll-like Receptor 2 Senses β-Cell Death and Contributes to the Initiation of Autoimmune Diabetes
Hun Sik Kim,Myoung Sook Han,Kun Wook Chung,Sunshin Kim,Eunshil Kim,Myoung Joo Kim,Eunkyeong Jang,Hyunah Lee,Jeehee Youn,Shizuo Akira,Myung-Shik Lee +10 more
TL;DR: It is observed that apoptotic cells undergoing secondary necrosis but not intact apoptosis cells provoked substantial immune responses, which were mediated through the toll-like receptor 2 (TLR2) pathway, showing that TLR2 plays an important role in the initiation of the disease.