Shizuo Akira

TL;DR: This work identifies inhibitor of κB kinase epsilon (IKBKE) as a new modulator of chronic inflammation in macrophages and establishes a nonpathogenic role for hematopoietic IKBKE in limiting inflammasome priming and metaflammation.

TL;DR: C/EBPβ is required for hormonal induction of the genes for ornithine cycle enzymes in primary‐cultured hepatocytes, while the deficiency of C/E BPβ is compensated for in vivo.

TL;DR: In this article, the role of microglia in glioma microenvironments in the mouse was investigated, and the authors found that microglias produce prostaglandin (PG)E2, which promotes the growth of tumor cells and possesses immunosuppressive activity.

TL;DR: It is demonstrated that inducible expression of NF-IL6 is able to increase endogenous gene expression of macrophage inflammatory protein (MIP)-1 alpha, osteopontin and CD14 in M1 cells, and activated murine MIP-1 alpha proximal promoter luciferase construct which contains two NF- IL6 binding sites and a point mutation of either site markedly reduces theLuciferase activity.

TL;DR: Rbm7 in epithelial cells plays a critical role in the development of fibrosis by regulating ncRNA decay and thereby the production of chemokines that recruit SatMs.