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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Differential Roles of Toll-Like Receptors 2 and 4 in In Vitro Responses of Macrophages to Legionella pneumophila
Morikazu Akamine,Futoshi Higa,Noriko Arakaki,Kazuyoshi Kawakami,Kiyoshi Takeda,Shizuo Akira,Atsushi Saito +6 more
TL;DR: The results show that TLR2, but not TLR4, is involved in murine innate immunity against L. pneumophila, although other TLRs may also contribute to innate immunity to this organism.
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TLR-Dependent Induction of IFN-β Mediates Host Defense against Trypanosoma cruzi
Ritsuko Koga,Shinjiro Hamano,Hirotaka Kuwata,Koji Atarashi,Masahiro Ogawa,Hajime Hisaeda,Masahiro Yamamoto,Shizuo Akira,Kunisuke Himeno,Makoto Matsumoto,Kiyoshi Takeda +10 more
TL;DR: Findings suggest that TLR-dependent expression of IFN-β is involved in resistance to T. cruzi infection through the induction of IRG47.
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Immune responses of TLR5+ lamina propria dendritic cells in enterobacterial infection
Satoshi Uematsu,Shizuo Akira +1 more
TL;DR: These LPDCs have unique properties in that they can induce acquired immunity as well as innate immunity via TLR5 in the intestine through a mechanism independent of gut-associated lymphoid tissue (GALT), and trigger the differentiation of antigen-specific Th17 and Th1 cells.
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Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice.
Marie-Alice Vitry,Carl De Trez,Stanislas Goriely,Laure Dumoutier,Shizuo Akira,Bernhard Ryffel,Yves Carlier,Jean-Jacques Letesson,Eric Muraille +8 more
TL;DR: A large panel of genetically deficient mice is used to compare the importance of B cells, transporter associated with antigen processing (TAP-1), and major histocompatibility complex class II-dependent pathways of antigen presentation as well as T helper 1 (Th1), Th2, and Th17-mediated responses on the immune control of Brucella melitensis 16 M infection to improve the ability to develop protective vaccines or therapeutic treatments against brucellosis.
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Glucocorticoids synergize with IL-1β to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells
TL;DR: Glucocorticoids synergistically enhance IL-1β-induced TLR2 expression via specific up-regulation of the MAP kinase phosphatase-1 that, in turn, leads to dephosphorylation and inactivation of both MAPK JNK and p38, the negative regulators forTLR2 induction.