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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
Takashi Tanaka,Shizuo Akira,Kanji Yoshida,Masanori Umemoto,Yoshihiro Yoneda,Naoki Shirafuji,Hiroshi Fujiwara,Sachiko Suematsu,Nobuaki Yoshida,Tadamitsu Kishimoto +9 more
TL;DR: It is demonstrated that NF-IL6 is essential for the induction of G-CSF in macrophages and fibroblasts and the existence of a NO-independent mechanism of these activities is demonstrated.
Journal ArticleDOI
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes
Melissa W. Boulé,Courtney Broughton,Fabienne Mackay,Shizuo Akira,Ann Marshak-Rothstein,Ian R. Rifkin +5 more
TL;DR: It is shown that murine DCs are much more effectively activated by immune complex that contain IgG bound to chromatin than by immune complexes that contain foreign protein.
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Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
Volaluck Supajatura,Hiroko Ushio,Atsuhito Nakao,Shizuo Akira,Ko Okumura,Chisei Ra,Hideoki Ogawa +6 more
TL;DR: Results suggest that direct activation of mast cells via TLR2 or TLR4 by respective microligands contributes to innate and allergic immune responses.
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IL-6 and NF-IL6 in acute-phase response and viral infection
Shizuo Akira,Tadamitsu Kishimoto +1 more
TL;DR: Results indicate that NF-IL6 may be a pleiotropic mediator of many inducible genes involved in acute, immune, and inflammatory responses, like NFkB.
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Toll-like receptors as adjuvant receptors
Tsuneyasu Kaisho,Shizuo Akira +1 more
TL;DR: Understanding the TLR system should offer invaluable opportunity for manipulating host immune responses, and accumulating evidence indicates that this can be attributed to both the common and unique aspects of the signaling mechanisms that mediate TLR family responses.