S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
Papers
More filters
Journal ArticleDOI
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis
Zachary J. Roberts,Nadege Goutagny,Pin Yu Perera,Hiroki Kato,Himanshu Kumar,Taro Kawai,Shizuo Akira,Ram Savan,David Van Echo,Katherine A. Fitzgerald,Howard A. Young,Lai-Ming Ching,Stefanie N. Vogel +12 more
TL;DR: The data demonstrate that 5,6-dimethylxanthenone-4-acetic acid is a novel and specific activator of the TANK-binding kinase 1 (TBK1)–interferon (IFN) regulatory factor 3 (IRF-3) signaling pathway and detail a novel pathway for TBK1-mediated IRF- 3 activation.
Journal ArticleDOI
Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.
Takuji Yamao,Tetsuya Noguchi,Osamu Takeuchi,Uichi Nishiyama,Haruhiko Morita,Tetsuya Hagiwara,Hironori Akahori,Takashi Kato,Kenjiro Inagaki,Hideki Okazawa,Yoshitake Hayashi,Takashi Matozaki,Kiyoshi Takeda,Shizuo Akira,Masato Kasuga +14 more
TL;DR: Results indicate that SHPS-1 both contributes to the survival of circulating platelets and down-regulates the macrophage phagocytic response.
Journal ArticleDOI
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2.
Akira Imasato,Christèle Desbois-Mouthon,Jiahuai Han,Hirofumi Kai,Andrew C.B. Cato,Shizuo Akira,Jian Dong Li +6 more
TL;DR: It is shown that glucocorticoids synergistically enhance NTHi-induced TLR2 expression via specific up-regulation of the MAPK phosphatase-1 (MKP-1) that, in turn, leads to dephosphorylation and inactivation of p38 MAPK, the negative regulator for TLR 2 expression.
Journal ArticleDOI
A New Subset of CD103+CD8α+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity
Kosuke Fujimoto,Thangaraj Karuppuchamy,Naoki Takemura,Masaki Shimohigoshi,Tomohisa Machida,Yasunari Haseda,Taiki Aoshi,Ken Ishii,Shizuo Akira,Satoshi Uematsu +9 more
TL;DR: A novel subset of CD8α+ LPDCs was analyzed to elucidate their immunological function and induced Ag-specific IgG in serum, a Th1 response, and CTL activity in vivo, the first analysis, to the authors' knowledge, of CD9α+ DCs in the LP of the small intestine.
Journal ArticleDOI
Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia.
Sylvia Knapp,Catharina W. Wieland,Sandrine Florquin,Ralph Pantophlet,Lenie Dijkshoorn,Ntambua Tshimbalanga,Shizuo Akira,Tom van der Poll +7 more
TL;DR: In this paper, the role of CD14 and Toll-like receptor 4 and 2 in host response to A. baumannii pneumonia was investigated, and the importance of LPS in the inflammatory response was studied.