S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1
Hidenori Iwasaki,Osamu Takeuchi,Shunsuke Teraguchi,Kazufumi Matsushita,Kazufumi Matsushita,Takuya Uehata,Kanako Kuniyoshi,Takashi Satoh,Tatsuya Saitoh,Mutsuyoshi Matsushita,Daron M. Standley,Shizuo Akira +11 more
TL;DR: It is demonstrated that the IKK complex phosphorylates not only IκBα, thereby activating transcription, but also regnase-1, thereby releasing a 'brake' on IL-6 mRNA expression.
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MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis
Akihiro Araki,Takanori Kanai,Takahiro Ishikura,Shin Makita,Koji Uraushihara,Ryoichi Iiyama,Teruji Totsuka,Kiyoshi Takeda,Shizuo Akira,Mamoru Watanabe +9 more
TL;DR: Findings suggest that, via MyD88 signaling, the innate immune system in the gut plays an important protective role in colitis.
Journal ArticleDOI
I[kgr]B[zgr] regulates TH17 development by cooperating with ROR nuclear receptors
Kazuo Okamoto,Yoshiko Iwai,Masatsugu Oh-hora,Masahiro Yamamoto,Tomohiro Morio,Kazuhiro Aoki,Keiichi Ohya,Anton M. Jetten,Shizuo Akira,Tatsushi Muta,Hiroshi Takayanagi +10 more
TL;DR: Evidence is provided for the transcriptional mechanisms underlying TH17 development and points to a molecular basis for a novel therapeutic strategy against autoimmune disease.
Journal ArticleDOI
ZIP Kinase, a Novel Serine/Threonine Kinase Which Mediates Apoptosis
TL;DR: The catalytic domain of ZIP kinase is closely related to that of death-associated protein kinase (DAP kinase), which is a mediator of apoptosis induced by gamma interferon, therefore, both ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities.
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Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.
Sanae Haga,Keita Terui,Hui Qi Zhang,Shin Enosawa,Wataru Ogawa,Hiroshi Inoue,Torayuki Okuyama,Kiyoshi Takeda,Shizuo Akira,Tetsuya Ogino,Kaikobad Irani,Michitaka Ozaki +11 more
TL;DR: Findings indicate that Stat3 activation protects against Fas-mediated liver injury by inhibiting caspase activities in redox-dependent and -independent mechanisms.