Shizuo Akira

TL;DR: Evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity, and this paradigm shift has changed thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.

TL;DR: It is shown that 2,6,10,14-tetramethylpentadecane induces a lupus-like disease in mice characterized by immune complex nephritis with autoantibodies to DNA and ribonucleoproteins by FcγRs and that TMPD elicits IFN-I production, monocyte recruitment, andAutoantibody production exclusively through a Toll-like receptor (TLR) 7– and myeloid differentiation factor 88 (

TL;DR: It is demonstrated that both NIK and IKKα are essential for the induction of NF-κB through LTβR, whereas the NIK–IKKα pathway is dispensable in TNFR-I signaling.

TL;DR: It is suggested that early induction of high levels of IL-12 by macrophages infected with type II strain parasites may contribute to more effective control, arguing against an active inhibition of signaling.

TL;DR: In this article, the authors show that TPT-treated cancer cells release exosomes that contain DNA that activate dendritic cells via STING signaling, and that a STING-dependent pathway drives antitumor immunity by responding to tumor cell-derived DNA.