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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture.
Shuhua Yang,Riyoko Tamai,Sachiko Akashi,Osamu Takeuchi,Shizuo Akira,Shunji Sugawara,Haruhiko Takada +6 more
TL;DR: It is suggested that LTA as well as LPS activated human monocytic cells in a CD14- and TLR4-dependent manner and exhibited synergistic and priming effects on the cells for cytokine production in response to various bacterial components.
Journal ArticleDOI
Role of adapters in Toll-like receptor signalling
TL;DR: Evidence is now accumulating showing that differential utilization of these adaptors may activate overlapping as well as distinct signalling pathways, and ultimately give rise to distinct biological effects exerted by individual TLR family members.
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Endotoxin can induce MyD88‐deficient dendritic cells to support Th2 cell differentiation
TL;DR: It is demonstrated that the MyD88-independent pathway through TLR4 can confer on DC the ability to support T(h)2 immune responses, as well as in vivo experiments with adjuvants.
Book ChapterDOI
Toll-Like receptors (TLRs) and their ligands.
Satoshi Uematsu,Shizuo Akira +1 more
TL;DR: The mechanism of pathogen recognition by Toll-like receptors is reviewed, which is capable of sensing organisms ranging from bacteria to fungi, protozoa, and viruses, and they play a major role in innate immunity.
Journal ArticleDOI
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.
Kira Bettermann,Mihael Vucur,Johannes Haybaeck,Christiane Koppe,Jörn Janssen,Felix Heymann,Achim Weber,Ralf Weiskirchen,Christian Liedtke,Nikolaus Gassler,Michael Müller,Rita Vos,Monika Julia Wolf,Yannick Boege,Gitta Maria Seleznik,Nicolas Zeller,Daniel Erny,Thomas J. Fuchs,Stefan Zoller,Stefano Cairo,Marie-Annick Buendia,Marco Prinz,Shizuo Akira,Frank Tacke,Mathias Heikenwalder,Christian Trautwein,Tom Luedde +26 more
TL;DR: Conditional ablation of TAK1 in liver parenchymal cells causes hepatocyte dysplasia and early-onset hepatocarcinogenesis, coinciding with biliary ductopenia and cholestasis and serves as a gatekeeper for a protumorigenic, NF-kappaB-independent function of NEMO in parenChymal liver cells.