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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Essential role of Stat6 in IL-4 signalling
Kiyoshi Takeda,Takashi Tanaka,Wei Shi,Makoto Matsumoto,Masashi Minami,Shin-ichiro Kashiwamura,Kenji Nakanishi,Nobuaki Yoshida,Tadamitsu Kishimoto,Shizuo Akira +9 more
TL;DR: It is concluded that Stat6 plays a central role in exerting IL-4-mediated biological responses, and production of Th2 cytokines from T cells as well as IgE and IgGl responses after nematode infection were profoundly reduced.
Journal ArticleDOI
The roles of TLRs, RLRs and NLRs in pathogen recognition
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized.
Journal ArticleDOI
A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.
Shizuo Akira,Hiroshi Isshiki,Takahisa Sugita,Osamu Tanabe,Shigemi Kinoshita,Yukihiro Nishio,Toshihiro Nakajima,Toshio Hirano,Tadamitsu Kishimoto +8 more
TL;DR: Interestingly, NF‐IL6 was shown to bind to the regulatory regions for various acute‐phase protein genes and several other cytokine genes such as TNF, IL‐8 and G‐CSF, implying that NF‐ IL6 has a role in regulation not only for the IL‐6 gene but also for several other genes involved in acute‐ phase reaction, inflammation and hemopoiesis.
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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Michaela U. Gack,Young C. Shin,Chul Hyun Joo,Chul Hyun Joo,Tomohiko Urano,Tomohiko Urano,Chengyu Liang,Lijun Sun,Osamu Takeuchi,Shizuo Akira,Zhijian J. Chen,Satoshi Inoue,Satoshi Inoue,Jae U. Jung +13 more
TL;DR: It is demonstrated that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic Rig-I signalling pathway to elicit host antiviral innate immunity.
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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
Hiroki Kato,Osamu Takeuchi,Eriko Mikamo-Satoh,Eriko Mikamo-Satoh,Reiko Hirai,Tomoji Kawai,Kazufumi Matsushita,Akane Hiiragi,Terence S. Dermody,Takashi Fujita,Shizuo Akira +10 more
TL;DR: It is shown that the length of dsRNA is important for differential recognition by RIG-I and MDA5, and the Mda5 ligand, polyinosinic-polycytidylic acid, was converted to a Rig-I ligand after shortening of the ds RNA length.