S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
Papers
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Journal ArticleDOI
IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice.
Taku Kodama,Tomohiro Matsuyama,Kozo Kuribayashi,Yasuhiro Nishioka,Minoru Sugita,Shizuo Akira,Kenji Nakanishi,Haruki Okamura +7 more
TL;DR: Findings indicate that in vivo IL-18 not only inhibited antigen-specific T(H2) development but also affected apoptosis through Fas-Fas ligand interactions, and these data support a role forIL-18 in the complex pathogenesis of allergic inflammation in which IL- 18 limited the development of the local inflammatory response to antigen.
Journal ArticleDOI
Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node
Adriana Flores-Langarica,Jennifer L. Marshall,Jessica Hitchcock,Charlotte N. Cook,Jonathan Jobanputra,Saeeda Bobat,Ewan A. Ross,Ruth E. Coughlan,Ian R. Henderson,Satoshi Uematsu,Shizuo Akira,Adam F. Cunningham +11 more
TL;DR: This study shows that systemic immunization with soluble FliC (sFliC) drives distinct immune responses concurrently in the mesenteric lymph nodes (MLN) and the spleen after i.p. and s.c. immunization, and offers a potential “Trojan horse” approach to modulate mucosal immunity by systemically immunizing with sFli C.
Book ChapterDOI
Toll-Like Receptors
TL;DR: This research presents a novel probabilistic approach called “Host Defense-guided cell reprograming” (HPD) that addresses the challenge of “blank-spatially aggregating immune cells” to defend against infection.
Journal ArticleDOI
Flagellin enhances tumor-specific CD8⁺ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model.
Chung Truong Nguyen,Seol Hee Hong,Jeong-Im Sin,Hong Van Dinh Vu,Kwangjoon Jeong,Kyoung Oh Cho,Satoshi Uematsu,Shizuo Akira,Shee Eun Lee,Joon Haeng Rhee +9 more
TL;DR: Results suggest that flagellin could enhance TA-specific CD8(+) CTL immune responses through TLR5 stimulation in cancer immunotherapy.
Journal Article
Effect of B cell differentiation factor (BCDF) on biosynthesis and secretion of immunoglobulin molecules in human B cell lines.
Hitoshi Kikutani,Tetsuya Taga,Shizuo Akira,H Kishi,Y Miki,Osamu Saiki,Yuichi Yamamura,Tadamitsu Kishimoto +7 more
TL;DR: The results suggest that BCDF induces an increase in the level of mRNA specific for secretory heavy chains, and then induces final maturation of B cells into immunoglobulin-secreting cells.