S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Toll-like receptors; their physiological role and signal transduction system
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: Analysis of knockout mice revealed a pivotal role for MyD88 in the signaling of the TLR/IL-1R family, and together, TLRs and the downstream signaling pathway play a key role in innate immune recognition and in subsequent activation of adaptive immunity.
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Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression
Akihisa Fukuda,Sam C. Wang,John P. Morris,Alexandra E. Folias,Angela Liou,Grace E. Kim,Shizuo Akira,Kenneth M. Boucher,Kenneth M. Boucher,Matthew A. Firpo,Matthew A. Firpo,Sean J. Mulvihill,Sean J. Mulvihill,Matthias Hebrok +13 more
TL;DR: Using a Kras-driven mouse model of PDA, it is established that the inflammatory mediator Stat3 is a critical component of spontaneous and pancreatitis-accelerated PDA precursor formation and supports cell proliferation, metaplasia-associated inflammation, and MMP7 expression during neoplastic development.
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Antiviral Signaling Through Pattern Recognition Receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: The role of TLRs and RLHs in the antiviral innate immune response is reviewed, located in endosomal compartments, whereas RLH are present in the cytoplasm where they detect viral dsRNA or ssRNA.
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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1|[beta]| production
Hendrik Poeck,Michael Bscheider,Olaf Gross,Olaf Gross,Katrin Finger,Susanne Roth,Manuele Rebsamen,Nicole Hannesschläger,Martin Schlee,Simon Rothenfusser,Winfried Barchet,Hiroki Kato,Shizuo Akira,Satoshi Inoue,Satoshi Inoue,Stefan Endres,Christian Peschel,Gunther Hartmann,Veit Hornung,Jürgen Ruland +19 more
TL;DR: The results identify the CARD9–Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish Rig-I as a sensor able to activate the inflammasome in response to certain RNA viruses.
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Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation
Asuka Suzuki,Toshikatsu Hanada,Keiichi Mitsuyama,Takafumi Yoshida,Shintaro Kamizono,Tomoaki Hoshino,Masato Kubo,Atsuko Yamashita,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira,Satoshi Matsumoto,Atsushi Toyonaga,Michio Sata,Akihiko Yoshimura +14 more
TL;DR: Data suggest that hyperactivation of STAT3 results in severe colitis and that CIS3 plays a negative regulatory role in intestinal inflammation by downregulating STAT3 activity.