Showing papers by "University of Wisconsin–Milwaukee published in 2020"
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TL;DR: In 2019, the LIGO Livingston detector observed a compact binary coalescence with signal-to-noise ratio 12.9 and the Virgo detector was also taking data that did not contribute to detection due to a low SINR but were used for subsequent parameter estimation as discussed by the authors.
Abstract: On 2019 April 25, the LIGO Livingston detector observed a compact binary coalescence with signal-to-noise ratio 12.9. The Virgo detector was also taking data that did not contribute to detection due to a low signal-to-noise ratio, but were used for subsequent parameter estimation. The 90% credible intervals for the component masses range from to if we restrict the dimensionless component spin magnitudes to be smaller than 0.05). These mass parameters are consistent with the individual binary components being neutron stars. However, both the source-frame chirp mass and the total mass of this system are significantly larger than those of any other known binary neutron star (BNS) system. The possibility that one or both binary components of the system are black holes cannot be ruled out from gravitational-wave data. We discuss possible origins of the system based on its inconsistency with the known Galactic BNS population. Under the assumption that the signal was produced by a BNS coalescence, the local rate of neutron star mergers is updated to 250-2810.
1,189 citations
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TL;DR: In this paper, the authors reported the observation of a compact binary coalescence involving a 222 −243 M ⊙ black hole and a compact object with a mass of 250 −267 M ⋆ (all measurements quoted at the 90% credible level) The gravitational-wave signal, GW190814, was observed during LIGO's and Virgo's third observing run on 2019 August 14 at 21:10:39 UTC and has a signal-to-noise ratio of 25 in the three-detector network.
Abstract: We report the observation of a compact binary coalescence involving a 222–243 M ⊙ black hole and a compact object with a mass of 250–267 M ⊙ (all measurements quoted at the 90% credible level) The gravitational-wave signal, GW190814, was observed during LIGO's and Virgo's third observing run on 2019 August 14 at 21:10:39 UTC and has a signal-to-noise ratio of 25 in the three-detector network The source was localized to 185 deg2 at a distance of ${241}_{-45}^{+41}$ Mpc; no electromagnetic counterpart has been confirmed to date The source has the most unequal mass ratio yet measured with gravitational waves, ${0112}_{-0009}^{+0008}$, and its secondary component is either the lightest black hole or the heaviest neutron star ever discovered in a double compact-object system The dimensionless spin of the primary black hole is tightly constrained to ≤007 Tests of general relativity reveal no measurable deviations from the theory, and its prediction of higher-multipole emission is confirmed at high confidence We estimate a merger rate density of 1–23 Gpc−3 yr−1 for the new class of binary coalescence sources that GW190814 represents Astrophysical models predict that binaries with mass ratios similar to this event can form through several channels, but are unlikely to have formed in globular clusters However, the combination of mass ratio, component masses, and the inferred merger rate for this event challenges all current models of the formation and mass distribution of compact-object binaries
913 citations
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National Center for Atmospheric Research1, University of Colorado Boulder2, Utrecht University3, Brown University4, Cooperative Institute for Research in Environmental Sciences5, University of Toronto6, University of Wisconsin–Milwaukee7, University of California, Irvine8, Columbia University9, Pacific Northwest National Laboratory10
TL;DR: The Community Earth System Model Version 2 (CESM2) as discussed by the authors is the most recent version of the Coupled Model Intercomparison Project (CMEI) coupled model.
Abstract: An overview of the Community Earth System Model Version 2 (CESM2) is provided, including a discussion of the challenges encountered during its development and how they were addressed. In addition, an evaluation of a pair of CESM2 long preindustrial control and historical ensemble simulations is presented. These simulations were performed using the nominal 1° horizontal resolution configuration of the coupled model with both the “low-top” (40 km, with limited chemistry) and “high-top” (130 km, with comprehensive chemistry) versions of the atmospheric component. CESM2 contains many substantial science and infrastructure improvements and new capabilities since its previous major release, CESM1, resulting in improved historical simulations in comparison to CESM1 and available observations. These include major reductions in low-latitude precipitation and shortwave cloud forcing biases; better representation of the Madden-Julian Oscillation; better El Nino-Southern Oscillation-related teleconnections; and a global land carbon accumulation trend that agrees well with observationally based estimates. Most tropospheric and surface features of the low- and high-top simulations are very similar to each other, so these improvements are present in both configurations. CESM2 has an equilibrium climate sensitivity of 5.1–5.3 °C, larger than in CESM1, primarily due to a combination of relatively small changes to cloud microphysics and boundary layer parameters. In contrast, CESM2's transient climate response of 1.9–2.0 °C is comparable to that of CESM1. The model outputs from these and many other simulations are available to the research community, and they represent CESM2's contributions to the Coupled Model Intercomparison Project Phase 6.
884 citations
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TL;DR: It is inferred that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M⊙, which can be considered an intermediate mass black hole (IMBH).
Abstract: On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.
876 citations
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University of Virginia1, McGill University2, National Radio Astronomy Observatory3, Goddard Space Flight Center4, West Virginia University5, Lafayette College6, Hillsdale College7, Durham University8, University of East Anglia9, University of Maryland, College Park10, First Green Bank11, University of British Columbia12, University of Toronto13, Hungarian Academy of Sciences14, Swinburne University of Technology15, University of Wisconsin–Milwaukee16, Chinese Academy of Sciences17
TL;DR: In this article, the authors measured the mass of the MSP J0740+6620 to be ${\mathbf{2.14} + 2.09} + 0.10% credibility interval.
Abstract: Despite its importance to our understanding of physics at supranuclear densities, the equation of state (EoS) of matter deep within neutron stars remains poorly understood. Millisecond pulsars (MSPs) are among the most useful astrophysical objects in the Universe for testing fundamental physics, and place some of the most stringent constraints on this high-density EoS. Pulsar timing—the process of accounting for every rotation of a pulsar over long time periods—can precisely measure a wide variety of physical phenomena, including those that allow the measurement of the masses of the components of a pulsar binary system1. One of these, called relativistic Shapiro delay2, can yield precise masses for both an MSP and its companion; however, it is only easily observed in a small subset of high-precision, highly inclined (nearly edge-on) binary pulsar systems. By combining data from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) 12.5-yr data set with recent orbital-phase-specific observations using the Green Bank Telescope, we have measured the mass of the MSP J0740+6620 to be $${\mathbf{2}}{\mathbf{.14}}_{ - {\mathbf{0}}{\mathbf{.09}}}^{ + {\mathbf{0}}{\mathbf{.10}}}$$ M⊙ (68.3% credibility interval; the 95.4% credibility interval is $${\mathbf{2}}{\mathbf{.14}}_{ - {\mathbf{0}}{\mathbf{.18}}}^{ + {\mathbf{0}}{\mathbf{.20}}}$$ M⊙). It is highly likely to be the most massive neutron star yet observed, and serves as a strong constraint on the neutron star interior EoS. Cromartie et al. have probably found the most massive neutron star discovered so far by combining NANOGrav 12.5-yr data with radio data from the Green Bank Telescope. Millisecond pulsar J0740+6620 has a mass of 2.14 M⊙, ~0.1 M⊙ more massive than the previous record holder, and very close to the upper limit on neutron star masses from Laser Interferometer Gravitational-Wave Observatory measurements.
770 citations
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TL;DR: In this article, the authors reported the observation of gravitational waves from a binary-black-hole coalescence during the first two weeks of LIGO and Virgo's third observing run.
Abstract: We report the observation of gravitational waves from a binary-black-hole coalescence during the first two weeks of LIGO’s and Virgo’s third observing run. The signal was recorded on April 12, 2019 at 05∶30∶44 UTC with a network signal-to-noise ratio of 19. The binary is different from observations during the first two observing runs most notably due to its asymmetric masses: a ∼30 M⊙ black hole merged with a ∼8 M⊙ black hole companion. The more massive black hole rotated with a dimensionless spin magnitude between 0.22 and 0.60 (90% probability). Asymmetric systems are predicted to emit gravitational waves with stronger contributions from higher multipoles, and indeed we find strong evidence for gravitational radiation beyond the leading quadrupolar order in the observed signal. A suite of tests performed on GW190412 indicates consistency with Einstein’s general theory of relativity. While the mass ratio of this system differs from all previous detections, we show that it is consistent with the population model of stellar binary black holes inferred from the first two observing runs.
507 citations
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Goddard Space Flight Center1, Widener University2, West Virginia University3, Montana State University4, Cornell University5, Canadian Institute for Advanced Research6, Centre national de la recherche scientifique7, University of Orléans8, Franklin & Marshall College9, University of Virginia10, United States Naval Research Laboratory11, Lafayette College12, National Radio Astronomy Observatory13, Hillsdale College14, Durham University15, McGill University16, University of British Columbia17, University of Washington18, Carnegie Mellon University19, University of Illinois at Urbana–Champaign20, University of Wisconsin–Milwaukee21, Northwestern University22, Oregon State University23, Rochester Institute of Technology24, California Institute of Technology25, University of Toronto26, First Green Bank27, University of Connecticut28, York University29, Eötvös Loránd University30, Vanderbilt University31, University of Colorado Boulder32, Swinburne University of Technology33, Oberlin College34
TL;DR: In this article, the authors search for an isotropic stochastic GWB in the 12.5-yr pulsar-timing data set collected by the North American Nanohertz Observatory for Gravitational Waves.
Abstract: We search for an isotropic stochastic gravitational-wave background (GWB) in the 12.5 yr pulsar-timing data set collected by the North American Nanohertz Observatory for Gravitational Waves. Our analysis finds strong evidence of a stochastic process, modeled as a power law, with common amplitude and spectral slope across pulsars. Under our fiducial model, the Bayesian posterior of the amplitude for an f −2/3 power-law spectrum, expressed as the characteristic GW strain, has median 1.92 × 10−15 and 5%–95% quantiles of 1.37–2.67 × 10−15 at a reference frequency of the Bayes factor in favor of the common-spectrum process versus independent red-noise processes in each pulsar exceeds 10,000. However, we find no statistically significant evidence that this process has quadrupolar spatial correlations, which we would consider necessary to claim a GWB detection consistent with general relativity. We find that the process has neither monopolar nor dipolar correlations, which may arise from, for example, reference clock or solar system ephemeris systematics, respectively. The amplitude posterior has significant support above previously reported upper limits; we explain this in terms of the Bayesian priors assumed for intrinsic pulsar red noise. We examine potential implications for the supermassive black hole binary population under the hypothesis that the signal is indeed astrophysical in nature.
431 citations
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TL;DR: The GW190521 signal is consistent with a binary black hole (BBH) merger source at redshift 0.13-0.30 Gpc-3 yr-1.8 as discussed by the authors.
Abstract: The gravitational-wave signal GW190521 is consistent with a binary black hole (BBH) merger source at redshift 0.8 with unusually high component masses, 85-14+21 M o˙ and 66-18+17 M o˙, compared to previously reported events, and shows mild evidence for spin-induced orbital precession. The primary falls in the mass gap predicted by (pulsational) pair-instability supernova theory, in the approximate range 65-120 M o˙. The probability that at least one of the black holes in GW190521 is in that range is 99.0%. The final mass of the merger (142-16+28 M o˙) classifies it as an intermediate-mass black hole. Under the assumption of a quasi-circular BBH coalescence, we detail the physical properties of GW190521's source binary and its post-merger remnant, including component masses and spin vectors. Three different waveform models, as well as direct comparison to numerical solutions of general relativity, yield consistent estimates of these properties. Tests of strong-field general relativity targeting the merger-ringdown stages of the coalescence indicate consistency of the observed signal with theoretical predictions. We estimate the merger rate of similar systems to be 0.13-0.11+0.30 Gpc-3 yr-1. We discuss the astrophysical implications of GW190521 for stellar collapse and for the possible formation of black holes in the pair-instability mass gap through various channels: via (multiple) stellar coalescences, or via hierarchical mergers of lower-mass black holes in star clusters or in active galactic nuclei. We find it to be unlikely that GW190521 is a strongly lensed signal of a lower-mass black hole binary merger. We also discuss more exotic possible sources for GW190521, including a highly eccentric black hole binary, or a primordial black hole binary.
347 citations
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University of Notre Dame1, Royal Institute of Technology2, Commonwealth Scientific and Industrial Research Organisation3, Massachusetts Institute of Technology4, Stanford University5, Georgia Institute of Technology6, Catalan Institute for Water Research7, University of Calabria8, University of Pisa9, Mario Negri Institute for Pharmacological Research10, Federal University of Bahia11, North Carolina State University12, Howard University13, Bangor University14, École Polytechnique Fédérale de Lausanne15, University of Arizona16, Southern Nevada Water Authority17, University of Barcelona18, University of Yamanashi19, University of California, Santa Barbara20, Hokkaido University21, Indian Institute of Technology Gandhinagar22, Toyama Prefectural University23, Istituto Superiore di Sanità24, University of Naples Federico II25, University of Wisconsin–Milwaukee26, University of Washington27, University of Queensland28, University of North Carolina at Chapel Hill29, University of Antwerp30, Yale University31, Tufts University32, Michigan State University33, Spanish National Research Council34, University of Southern California35, Rice University36, Georgia State University37, University of Osnabrück38, University of Michigan39
TL;DR: Author(s): Bivins, Aaron; North, Devin; Ahmad, Arslan; Ahmed, Warish; Alm, Eric; Been, Frederic; Bhattacharya, Prosun; Bijlsma, Lubertus; Boehm, Alexandria B; Brown, Joe; Buttiglieri, Gianluigi; Calabro, Vincenza; Carducci, Annalaura; Castiglioni, Sara; Cetecioglu Guro
Abstract: Author(s): Bivins, Aaron; North, Devin; Ahmad, Arslan; Ahmed, Warish; Alm, Eric; Been, Frederic; Bhattacharya, Prosun; Bijlsma, Lubertus; Boehm, Alexandria B; Brown, Joe; Buttiglieri, Gianluigi; Calabro, Vincenza; Carducci, Annalaura; Castiglioni, Sara; Cetecioglu Gurol, Zeynep; Chakraborty, Sudip; Costa, Federico; Curcio, Stefano; de Los Reyes, Francis L; Delgado Vela, Jeseth; Farkas, Kata; Fernandez-Casi, Xavier; Gerba, Charles; Gerrity, Daniel; Girones, Rosina; Gonzalez, Raul; Haramoto, Eiji; Harris, Angela; Holden, Patricia A; Islam, Md Tahmidul; Jones, Davey L; Kasprzyk-Hordern, Barbara; Kitajima, Masaaki; Kotlarz, Nadine; Kumar, Manish; Kuroda, Keisuke; La Rosa, Giuseppina; Malpei, Francesca; Mautus, Mariana; McLellan, Sandra L; Medema, Gertjan; Meschke, John Scott; Mueller, Jochen; Newton, Ryan J; Nilsson, David; Noble, Rachel T; van Nuijs, Alexander; Peccia, Jordan; Perkins, T Alex; Pickering, Amy J; Rose, Joan; Sanchez, Gloria; Smith, Adam; Stadler, Lauren; Stauber, Christine; Thomas, Kevin; van der Voorn, Tom; Wigginton, Krista; Zhu, Kevin; Bibby, Kyle
325 citations
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Alexander G. Bick, Joshua S. Weinstock1, Satish K. Nandakumar2, Satish K. Nandakumar3 +162 more•Institutions (49)
TL;DR: Analysis of high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine programme enables simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells.
Abstract: Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown1. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been associated with both haematological cancer2-4 and coronary heart disease5-this phenomenon is termed clonal haematopoiesis of indeterminate potential (CHIP)6. Simultaneous analyses of germline and somatic whole-genome sequences provide the opportunity to identify root causes of CHIP. Here we analyse high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine (TOPMed) programme, and identify 4,229 individuals with CHIP. We identify associations with blood cell, lipid and inflammatory traits that are specific to different CHIP driver genes. Association of a genome-wide set of germline genetic variants enabled the identification of three genetic loci associated with CHIP status, including one locus at TET2 that was specific to individuals of African ancestry. In silico-informed in vitro evaluation of the TET2 germline locus enabled the identification of a causal variant that disrupts a TET2 distal enhancer, resulting in increased self-renewal of haematopoietic stem cells. Overall, we observe that germline genetic variation shapes haematopoietic stem cell function, leading to CHIP through mechanisms that are specific to clonal haematopoiesis as well as shared mechanisms that lead to somatic mutations across tissues.
300 citations
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National Institute for Health Research1, Harvard University2, Montreal Heart Institute3, University of North Carolina at Chapel Hill4, Wellcome Trust Sanger Institute5, VA Boston Healthcare System6, Osaka University7, Icahn School of Medicine at Mount Sinai8, University of Wisconsin–Milwaukee9, Kyushu University10, University of Washington11, University of Bristol12, University of Copenhagen13, Erasmus University Medical Center14, National Institutes of Health15, Veterans Health Administration16, Kaiser Permanente17, International Agency for Research on Cancer18, Wake Forest University19, Imperial College London20, Broad Institute21, Greifswald University Hospital22, University of Pennsylvania23, British Heart Foundation24, Fred Hutchinson Cancer Research Center25, Chinese National Human Genome Center26, Technische Universität München27, University of Tampere28, University of Tokyo29, University of Ioannina30, University of Colorado Denver31, Duke University32, University of Virginia33, University of Minnesota34, Turku University Hospital35, Los Angeles Biomedical Research Institute36, Stanford University37, Mashhad University of Medical Sciences38, NHS Blood and Transplant39, Brigham and Women's Hospital40, University of Oxford41, University of Liège42, European Bioinformatics Institute43, John Radcliffe Hospital44
TL;DR: The results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation.
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TL;DR: In this paper, the authors review the physics of pair-density wave superconductors and discuss the order induced by PDW states, such as charge density wave, and discuss relativities.
Abstract: We review the physics of pair-density wave (PDW) superconductors. We begin with a macroscopic description that emphasizes order induced by PDW states, such as charge-density wave, and discuss relat...
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University of North Carolina at Chapel Hill1, Montreal Heart Institute2, Osaka University3, VA Boston Healthcare System4, Icahn School of Medicine at Mount Sinai5, Queen Mary University of London6, University of Cambridge7, National Institute for Health Research8, Wellcome Trust Sanger Institute9, Harvard University10, Vanderbilt University11, University of Wisconsin–Milwaukee12, Université de Montréal13, University of Southern California14, Kyushu University15, University of Washington16, University of Bristol17, University of Copenhagen18, Erasmus University Medical Center19, National Institutes of Health20, Brigham and Women's Hospital21, Kaiser Permanente22, University of Mississippi Medical Center23, International Agency for Research on Cancer24, Wake Forest University25, Imperial College London26, Broad Institute27, University of Pennsylvania28, Greifswald University Hospital29, Fred Hutchinson Cancer Research Center30, Chinese National Human Genome Center31, Technische Universität München32, University of Tampere33, University of Tokyo34, University of Ioannina35, University of Colorado Denver36, Duke University37, University of Virginia38, NHS Blood and Transplant39, University of Minnesota40, Turku University Hospital41, Los Angeles Biomedical Research Institute42, Stanford University43, King's College London44, Mashhad University of Medical Sciences45, Veterans Health Administration46
TL;DR: The clinical significance and predictive value of trans-ethnic variants in multiple populations are explored, genetic architecture and the effect of natural selection on these blood phenotypes between populations are compared and the value of a more global representation of populations in genetic studies is highlighted.
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Monash University, Clayton campus1, California Institute of Technology2, Massachusetts Institute of Technology3, Cardiff University4, Northwestern University5, University of Glasgow6, Lancaster University7, Swinburne University of Technology8, University of Paris9, University of Minnesota10, Indian Institute of Technology Bombay11, York University12, Georgia Institute of Technology13, IAC14, Albert Einstein Institution15, University of Oregon16, University of Wisconsin–Milwaukee17, IFAE18, Australia Telescope National Facility19, University of Florida20, Sapienza University of Rome21, University of Melbourne22, University of Tokyo23, University of Birmingham24
TL;DR: This work demonstrates that bilby produces reliable results for simulated gravitational-wave signals from compact binary mergers, and verify that it accurately reproduces results reported for the 11 GWTC-1 signals.
Abstract: Gravitational waves provide a unique tool for observational astronomy. While the first LIGO–Virgo catalogue of gravitational-wave transients (GWTC-1) contains 11 signals from black hole and neutron star binaries, the number of observations is increasing rapidly as detector sensitivity improves. To extract information from the observed signals, it is imperative to have fast, flexible, and scalable inference techniques. In a previous paper, we introduced bilby: a modular and user-friendly Bayesian inference library adapted to address the needs of gravitational-wave inference. In this work, we demonstrate that bilby produces reliable results for simulated gravitational-wave signals from compact binary mergers, and verify that it accurately reproduces results reported for the 11 GWTC-1 signals. Additionally, we provide configuration and output files for all analyses to allow for easy reproduction, modification, and future use. This work establishes that bilby is primed and ready to analyse the rapidly growing population of compact binary coalescence gravitational-wave signals.
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TL;DR: A genome-wide association study including 133,384 breast cancer cases and 113,789 controls plus 18,908 BRCA1 mutation carriers of European ancestry provides an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.
Abstract: Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade. We identified 32 novel susceptibility loci (P < 5.0 × 10-8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate < 0.05). Five loci showed associations (P < 0.05) in opposite directions between luminal and non-luminal subtypes. In silico analyses showed that these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 54.2% for luminal A-like disease and 37.6% for triple-negative disease. The odds ratios of polygenic risk scores, which included 330 variants, for the highest 1% of quantiles compared with middle quantiles were 5.63 and 3.02 for luminal A-like and triple-negative disease, respectively. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.
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Durham University1, Charles University in Prague2, Memorial University of Newfoundland3, McGill University4, Dalhousie University5, Minnesota Department of Natural Resources6, Alberta Geological Survey7, University of Wisconsin-Madison8, Laurentian University9, Université du Québec à Rimouski10, University of Exeter11, Geological Survey of Canada12, University of Maine13, University at Buffalo14, Université du Québec à Montréal15, Laval University16, Oregon State University17, Simon Fraser University18, University of Illinois at Urbana–Champaign19, Government of Quebec20, Western Washington University21, State University of New York at Plattsburgh22, University of Copenhagen23, University of Wisconsin–Milwaukee24, University of Minnesota25, University of Gothenburg26, Western Michigan University27, University College Dublin28, Geological Survey of Denmark and Greenland29, Indiana University30, University of Cincinnati31, Norwegian University of Science and Technology32, Université de Montréal33, Tufts University34, University of Waterloo35, University of Manitoba36, Alberta Environment37
TL;DR: The most up-to-date and authoritative margin chronology for the entire ice sheet complex is featured in two publications (Geological Survey of Canada Open File 1574 [Dyke et al., 2003] and as mentioned in this paper ).
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TL;DR: The LIGO Scientific Collaboration and the Virgo Collaboration have cataloged eleven confidently detected gravitational-wave events during the first two observing runs of the advanced detector era as discussed by the authors.
Abstract: The LIGO Scientific Collaboration and the Virgo Collaboration have cataloged eleven confidently detected gravitational-wave events during the first two observing runs of the advanced detector era. All eleven events were consistent with being from well-modeled mergers between compact stellar-mass objects: black holes or neutron stars. The data around the time of each of these events have been made publicly available through the gravitational-wave open science center. The entirety of the gravitational-wave strain data from the first and second observing runs have also now been made publicly available. There is considerable interest among the broad scientific community in understanding the data and methods used in the analyses. In this paper, we provide an overview of the detector noise properties and the data analysis techniques used to detect gravitational-wave signals and infer the source properties. We describe some of the checks that are performed to validate the analyses and results from the observations of gravitational-wave events. We also address concerns that have been raised about various properties of LIGO–Virgo detector noise and the correctness of our analyses as applied to the resulting data.
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Wellcome Trust Sanger Institute1, National Institute for Health Research2, Broad Institute3, Boston Children's Hospital4, Montreal Heart Institute5, British Heart Foundation6, University of North Carolina at Chapel Hill7, VA Boston Healthcare System8, NHS Blood and Transplant9, University of Cambridge10, Osaka University11, Icahn School of Medicine at Mount Sinai12, University of Wisconsin–Milwaukee13, Kyushu University14, University of Washington15, University of Bristol16, University of Copenhagen17, Hasso Plattner Institute18, Erasmus University Medical Center19, National Institutes of Health20, Brigham and Women's Hospital21, Harvard University22, Kaiser Permanente23, University of Mississippi Medical Center24, International Agency for Research on Cancer25, University of Ioannina26, Wake Forest University27, Greifswald University Hospital28, University of Pennsylvania29, Fred Hutchinson Cancer Research Center30, Chinese National Human Genome Center31, Technische Universität München32, University of Tampere33, University of Tokyo34, University of Colorado Denver35, Frederiksberg Hospital36, Duke University37, University of Virginia38, University of Minnesota39, Turku University Hospital40, University of Turku41, Los Angeles Biomedical Research Institute42, Stanford University43, Université de Montréal44, Veterans Health Administration45, University of Oxford46, University of Liège47, European Bioinformatics Institute48, Imperial College London49, John Radcliffe Hospital50, Churchill Hospital51
TL;DR: These results show the power of large-scale blood cell GWAS to interrogate clinically meaningful variants across the full allelic spectrum of human variation.
Abstract: Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including 563,946 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering the full allele frequency spectrum of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood cell traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell GWAS to interrogate clinically meaningful variants across the full allelic spectrum of human variation.
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TL;DR: In this paper, a comprehensive review of the properties of UHPC and its application in bridge engineering is provided, including jointed and jointless bridge components, such as piers, girders, decks, and link slabs.
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TL;DR: The simulation results show that the total costs can be effectively reduced by adopting coordinated charging/discharging mode for EVs, and that the consumers’ total cost can be further reduced by implementing the DR programs.
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TL;DR: The study elucidates the AgNPs synthesized using cellfree culture supernatant can be used for the elimination of hazardous pollutants from wastewater and exhibits significant activity on A549 cells, which was dosedependent.
Abstract: The present study reports the biosynthesis of silver nanoparticles (AgNPs) using Bacillus amyloliquefaciens MSR5. The cellfree supernatant of B. amyloliquefaciens acted as a stabilizing agent for the synthesis of AgNPs. The synthesized AgNPs were characterized using UV-vis spectrophotometer, PXRD, FTIR, SEM-EDX, DLS, and TEM. TEM image showed the spherical shape of the biosynthesized AgNPs and it was found to be 20-40 nm in range. In this study, the AgNPs were prepared by ultrasonic irradiation. The stability of the AgNPs was found to be -33.4 mV using zeta potential. The catalytic 4-nitrophenol (4-NP) degradation by AgNPs was examined under solar irradiation and furthermore, the effects of several degradation parameters were studied. The biosynthesized AgNPs exhibited a strong chemocatalytic action with a comprehensive degradation (98%) of 4-NP to 4-aminophenol (4-AP) using NaBH4 within 15 min. In addition, MTT assay was performed to evaluate the cytotoxicity of the biosynthesized AgNPs (10 - 200 μg). The results have shown that the AgNPs exhibited significant activity on A549 cells, which was dosedependent. The study elucidates the AgNPs synthesized using cellfree culture supernatant can be used for the elimination of hazardous pollutants from wastewater.
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TL;DR: Zhang et al. as discussed by the authors proposed a multi-source, multi-temporal random forest classification (MSMT_RF) method based on the Google Earth Engine (GEE) platform.
Abstract: . The amount of impervious surface is an important indicator in the monitoring of the intensity of human activity and environmental change. The use of remote sensing techniques is the only means of accurately carrying out global mapping of impervious surfaces covering large areas. Optical imagery can capture surface reflectance characteristics, while synthetic aperture radar (SAR) images can be used to provide information on the structure and dielectric properties of surface materials. In addition, night-time light (NTL) imagery can detect the intensity of human activity and thus provide important a priori probabilities of the occurrence of impervious surfaces. In this study, we aimed to generate an accurate global impervious surface map at a resolution of 30-m for 2015 by combining Landsat-8 OLI optical images, Sentinel-1 SAR images and VIIRS NTL images based on the Google Earth Engine (GEE) platform. First, the global impervious and non-impervious training samples were automatically derived by combining the GlobeLand30 land-cover product with VIIRS NTL and MODIS enhanced vegetation index (EVI) imagery. Then, based on global training samples and multi-source and multi-temporal imagery, a random forest classifier was trained and used to generate corresponding impervious surface maps for each 5°×5° cell of a geographical grid. Finally, a global impervious surface map, produced by mosaicking numerous 5°×5° regional maps, was validated by interpretation samples and then compared with three existing impervious products (GlobeLand30, FROM_GLC and NUACI). The results indicated that the global impervious surface map produced using the proposed multi-source, multi-temporal random forest classification (MSMT_RF) method was the most accurate of the maps, having an overall accuracy of 96.6 % and kappa coefficient of 0.903 as against 92.5 % and 0.769 for FROM_GLC, 91.1 % and 0.717 for GlobeLand30, and 87.43 % and 0.585 for NUACI. Therefore, it is concluded that a global 30-m impervious surface map can accurately and efficiently be generated by the proposed MSMT_RF method based on the GEE platform. The global impervious surface map generated in this paper are available at https://doi.org/10.5281/zenodo.3505079 (Zhang et al., 2019).
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TL;DR: In this paper, a critical review summarizes the utilization of algae as the resilient source for biofuel and validates the different stages in generation of biofuels and provides a clarity on III generation bio-fuels.
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TL;DR: While the advent of Covid-19 has required nurse faculty to be innovative, flexible, nimble, and agile, there have been challenges.
Abstract: While the advent of Covid-19 has required nurse faculty be innovative, flexible, nimble, and agile, there have been challenges. For example, faculty have had to move in-person classes online; conceptualize and offer alternative clinical experiences; and re-define how student performance is evaluated and graded. When we look back on this experience, what will faculty have learned from these experiences, and what are possible changes arising from these learnings?
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TL;DR: In this paper, a review of recent progress in the synthesis of metal-matrix graphene nanocomposites using powder metallurgy technique involving milling, compaction, and extrusion or rolling with special emphasis on the agglomeration of graphene, interfacial bonding, and reaction between metal matrix and graphene has been critically reviewed.
Abstract: Although significant effort has been made on using graphene as a reinforcement in metal matrix nanocomposites due to its extraordinary high strength and high modulus, metal-matrix graphene nanocomposites still exhibit large scatters in experimentally measured physical and mechanical properties. In this paper, recent progress in research on the synthesis of metal-matrix graphene nanocomposites using powder metallurgy technique involving milling, compaction, and extrusion or rolling with special emphasis on the agglomeration of graphene, interfacial bonding, and reaction between metal-matrix and graphene has been critically reviewed. Strengthening mechanisms such as grain refinement, oxide dispersions, strengthening, impeding of dislocations by reinforcement, load transfer between the matrix and graphene, and CTE mismatch in the metal-matrix graphene nanocomposites has been discussed. Existing theoretical models on the effects of graphene on mechanical properties including tribological behavior will also be discussed and compared with experimental observations. Potential future research directions in the area of graphene-reinforced MMNC will be outlined.
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21 Jul 2020
TL;DR: In this paper, an even-parity chiral superconducting order parameter for strontium ruthenate was proposed and shown to stabilize such a pairing state at weak coupling but only once small symmetry-allowed inter-layer spin-orbit coupling terms are taken into account.
Abstract: This paper proposes an even-parity chiral superconducting order parameter for strontium ruthenate. Using a three-dimensional three-band model for the band structure, the authors show that local interactions can stabilize such an even-parity pairing state at weak coupling but only once small symmetry-allowed inter-layer spin-orbit coupling terms are taken into account.
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TL;DR: The distribution of branched PFAS isomers is not consistent in the environment, however as mentioned in this paper found that linear PFAS sorb preferentially to soil and sediments, whereas branches are more likely to remain in water.
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TL;DR: The results showed that the dietary OEO significantly improved the growth parameters (final body weight, weight gain, Weight gain %, specific growth rate, and feed intake) (P).