Design strategies and application progress of therapeutic exosomes.
Chunying Liu,Changqing Su +1 more
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TLDR
The methods for loading specific treating molecules (proteins, nucleic acids and small chemicals) into exosomes, the design strategies for cell and tissue targeting, and the factors for exosome formation are discussed.Abstract:
Exosomes have great potential to be drug delivery vehicles due to their natural material transportation properties, intrinsic long-term circulatory capability, and excellent biocompatibility, which are suitable for delivering a variety of chemicals, proteins, nucleic acids, and gene therapeutic agents. However, an effective method of loading specific protein agents into exosomes for absorption by target cells is still lacking. The application potential of exosome is still limited. In this review, we discussed the methods for loading specific treating molecules (proteins, nucleic acids and small chemicals) into exosomes, the design strategies for cell and tissue targeting, and the factors for exosome formation. This review can be used as a reference for further research as well as for the development of therapeutic exosomes.read more
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Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics.
Dongbin Yang,Weihong Zhang,Huanyun Zhang,Fengqiu Zhang,Lanmei Chen,Lixia Ma,Leon M Larcher,Suxiang Chen,Nan Liu,Qingxia Zhao,Phuong H.L. Tran,Changying Chen,Rakesh N. Veedu,Tao Wang,Tao Wang +14 more
TL;DR: A panoramic view of current exosome isolation techniques is provided, providing perspectives toward the development of novel approaches for high-efficient exosomes isolation from various types of biological matrices.
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A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?
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MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway
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TL;DR: AMSC-Exo- 199a can be an effective vehicle for miR-199a delivery, and they effectively sensitized HCC to chemotherapeutic agents by targeting mTOR pathway and subsequently inhibiting the m TOR pathway.
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Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy
Gi Hoon Nam,Yoonjeong Choi,Yoonjeong Choi,Gi Beom Kim,Gi Beom Kim,Seohyun Kim,Seohyun Kim,Seong A. Kim,Seong A. Kim,In San Kim,In San Kim +10 more
TL;DR: The advantages of exosomes for treating cancer and the challenges that must be overcome for their successful clinical development are discussed.
References
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