Journal ArticleDOI
Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury
TLDR
The evidence that exosomes could be used as a neurorestorative therapy after stroke or traumatic brain injury is discussed and how engineering of their microRNA cargo could optimize this approach.Abstract:
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and their families, but currently no drugs on the market promote neurological recovery. Limited spontaneous recovery of function as a result of brain remodelling after stroke or injury does occur, and cell-based therapies have been used to promote these endogenous processes. Increasing evidence is demonstrating that the positive effects of such cell-based therapy are mediated by exosomes released from the administered cells and that the microRNA cargo in these exosomes is largely responsible for the therapeutic effects. This evidence raises the possibility that isolated exosomes could be used alone as a neurorestorative therapy and that these exosomes could be tailored to maximize clinical benefit. The potential of exosomes as a therapy for brain disorders is therefore being actively investigated. In this Review, we discuss the current knowledge of exosomes and advances in our knowledge of their effects on endogenous neurovascular remodelling events. We also consider the opportunities for exosome-based approaches to therapeutic amplification of brain repair and improvement of recovery after stroke, traumatic brain injury and other diseases in which neurorestoration could be a viable treatment strategy.read more
Citations
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Journal ArticleDOI
Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release.
Min Wang,Chenggui Wang,Chenggui Wang,Mi Chen,Yuewei Xi,Wei Cheng,Cong Mao,Tianzhen Xu,Xingxing Zhang,Cai Lin,Weiyang Gao,Yi Guo,Bo Lei +12 more
TL;DR: An injectable adhesive thermosensitive multifunctional polysaccharide-based dressing with sustained pH-responsive exosomes release with great potential in achieving satisfactory healing in diabetic and other vascular-impaired related wounds was fabricated.
Journal ArticleDOI
Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury.
Shaowei Guo,Shaowei Guo,Nisim Perets,Oshra Betzer,Shahar Ben-Shaul,Anton Sheinin,Izhak Michaelevski,Rachela Popovtzer,Daniel Offen,Shulamit Levenberg +9 more
TL;DR: It is demonstrated that when given intranasally, exosomes derived from mesenchymal stem cells could pass the blood brain barrier, and migrate to the injured spinal cord area, and MSC-Exo loaded with phosphatase and tensin homolog small interfering RNA (ExoPTEN) could attenuate the expression of PTEN in thejured spinal cord region followingintranasal administrations.
Journal ArticleDOI
Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer.
Changhao Chen,Yuming Luo,Wang He,Yue Zhao,Yao Kong,Hongwei Liu,Guangzheng Zhong,Yuting Li,Jun Li,Jian Huang,Rufu Chen,Tianxin Lin +11 more
TL;DR: This work demonstrated that BCa cell-secreted exosomes-mediated lymphangiogenesis promoted LN metastasis in BCa, which was in a VEGF-C-independent manner, and identified an exosomal long noncoding RNA (lncRNA), termed lymph node metastasis-associated transcript 2 (LNMAT2), which stimulated HLEC tube formation and migration in vitro and enhanced tumor lymphang iogenesis and LN tumours in vivo.
Journal ArticleDOI
Exosome engineering: Current progress in cargo loading and targeted delivery
TL;DR: The biogenesis, contents and functions of natural exosomes are summarized, and a comprehensive discussion for the strategies of exosomal cargo loading and membrane modification for targeted delivery is provided.
Journal ArticleDOI
Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models.
Li Yang,Bing Han,Zhiting Zhang,Zhiting Zhang,Zhiting Zhang,Shuguo Wang,Ying Bai,Yuan Zhang,Ying Tang,Du Lingli,Ling Xu,Fangfang Wu,Lei Zuo,Xufeng Chen,Yu Lin,Kezhong Liu,Qingqing Ye,Biling Chen,Bin Li,Tang Tianci,Yu Wang,Ling Shen,Guangtian Wang,Minzi Ju,Mengqin Yuan,Wei Jiang,John H. Zhang,John H. Zhang,Gang Hu,Jianhong Wang,Honghong Yao,Honghong Yao +31 more
TL;DR: Rabies virus glycoprotein-circSCMH1-extracellular vesicles afford protection by promoting functional recovery in the rodent and the nonhuman primate ischemic stroke models and demonstrates the basic mechanism of how circRNAs can be therapeutically exploited to improve poststroke outcomes.
References
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Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats
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