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Polyphenols and neuroprotection: Therapeutic implications for cognitive decline
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In this paper , the authors discuss the potential mechanisms involved in age-related cognitive decline or early stage cognitive impairment and current evidence from clinical human studies conducted on polyphenols and the aforementioned outcomes.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2022-04-01. It has received 45 citations till now. The article focuses on the topics: Cognitive decline & Cognition.read more
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Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer’s Disease
Giuseppe Caruso,Justyna Godos,Anna Provvidenza Privitera,Giuseppe Lanza,Sabrina Castellano,Alessio Chillemi,Oliviero Bruni,Raffaele Ferri,Filippo Caraci,Giuseppe Grosso +9 more
TL;DR: Preclinical evidence is provided that different dietary polyphenols such as rosmarinic acid, ellagic acid, and cinnamic aldehyde can exert neuroprotective and pro-cognitive activities through different molecular mechanisms including the modulation of pro-oxidant and antioxidant machinery as well as inflammatory status.
Journal ArticleDOI
Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction
Giuseppe Grosso,Daniela Laudisio,Evelyn Frias-Toral,Luigi Barrea,Giovanna Muscogiuri,Silvia Savastano,Annamaria Colao +6 more
TL;DR: Overall, evidence suggests that dietary factors may affect the immune system regardless of obesity-related inflammation.
Journal ArticleDOI
Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
Silvia Di Giacomo,Ester Percaccio,Marco Gullì,Adele Romano,Annabella Vitalone,M. Mazzanti,Silvana Gaetani,Antonella Di Sotto +7 more
TL;DR: The aim of the present narrative review is to provide an overview on the existing preclinical and clinical evidence about the neuroprotective properties and mechanisms of action of ferulic acid, also focusing on its ability to modulate glucose homeostasis, in order to support a further therapeutic interest for AD and type 3 diabetes.
Journal ArticleDOI
An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents β-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans
TL;DR: In this article , the effects of an olive fruit extract 20% rich in hydroxytyrosol on the molecular mechanisms associated with Alzheimer disease features like Aβ- and tau- induced toxicity, as well as on oxidative stress in Caenorhabditis elegans were investigated.
Journal ArticleDOI
The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases
TL;DR: In this article , the role of polyphenols in slowing down the progression of neurodegenerative diseases via the microbiota-gut-brain (MGB) axis was investigated.
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Starodubov,Vasiliki Stathopoulou,Dan J. Stein,Caitlyn Steiner,Leo G Stewart,Mark A. Stokes,Michelle L Subart,Agus Sudaryanto,Mu'awiyyah Babale Sufiyan,Patrick J Sur,Ipsita Sutradhar,Bryan L. Sykes,P N Sylaja,Dillon O Sylte,Cassandra Szoeke,Rafael Tabarés-Seisdedos,Takahiro Tabuchi,Santosh Kumar Tadakamadla,Ken Takahashi,Nikhil Tandon,Segen Gebremeskel Tassew,Nuno Taveira,Arash Tehrani-Banihashemi,Tigist Gashaw Tekalign,Merhawi Gebremedhin Tekle,Mohamad-Hani Temsah,Omar Temsah,Abdullah Sulieman Terkawi,Manaye Yihune Teshale,Belay Tessema,Gizachew Assefa Tessema,Kavumpurathu Raman Thankappan,Sathish Thirunavukkarasu,Nihal Thomas,Amanda G. Thrift,George D. Thurston,Binyam Tilahun,Quyen G. To,Ruoyan Tobe-Gai,Marcello Tonelli,Roman Topor-Madry,Anna E. Torre,Miguel Tortajada-Girbés,Mathilde Touvier,Marcos Roberto Tovani-Palone,Bach Xuan Tran,Khanh Bao Tran,Suryakant Tripathi,Christopher Troeger,Thomas Truelsen,Nu Thi Truong,Afewerki Gebremeskel Tsadik,Derrick Tsoi,Lorainne Tudor Car,E. Murat Tuzcu,Stefanos Tyrovolas,Kingsley N. Ukwaja,Irfan Ullah,Eduardo A. Undurraga,Rachel L Updike,Muhammad Usman,Olalekan A. Uthman,Selen Begüm Uzun,Muthiah Vaduganathan,Afsane Vaezi,Gaurang Vaidya,Pascual R. Valdez,Elena Varavikova,Tommi Vasankari,Narayanaswamy Venketasubramanian,Santos Villafaina,Francesco Saverio Violante,Sergey K Vladimirov,Vasily Vlassov,Stein Emil Vollset,Theo Vos,Gregory R. Wagner,Fasil Wagnew,Yasir Waheed,Mitchell T. Wallin,Judd L. Walson,Yanping Wang,Yuan-Pang Wang,Molla Mesele Wassie,Elisabete Weiderpass,Robert G. Weintraub,Fitsum Weldegebreal,Kidu Gidey Weldegwergs,Andrea Werdecker,Adhena Ayaliew Werkneh,T. Eoin West,Ronny Westerman,Harvey Whiteford,Justyna Widecka,Lauren B. Wilner,Shadrach Wilson,Andrea Sylvia Winkler,Charles Shey Wiysonge,Charles D.A. Wolfe,Shouling Wu,Yun-Chun Wu,Grant M A Wyper,Denis Xavier,Gelin Xu,Simon Yadgir,Ali Yadollahpour,Seyed Hossein Yahyazadeh Jabbari,Bereket Yakob,Lijing L. Yan,Yuichiro Yano,Mehdi Yaseri,Yasin Jemal Yasin,Gokalp Kadri Yentur,Alex Yeshaneh,Ebrahim M Yimer,Paul S. F. Yip,Biruck Desalegn Yirsaw,Engida Yisma,Naohiro Yonemoto,Gerald Yonga,Seok Jun Yoon,Marcel Yotebieng,Mustafa Z. Younis,Mahmoud Yousefifard,Chuanhua Yu,Vesna Zadnik,Zoubida Zaidi,Sojib Bin Zaman,Mohammad Zamani,Zohreh Zare,Ayalew Jejaw Zeleke,Zerihun Menlkalew Zenebe,Anthony Lin Zhang,Kai Zhang,Maigeng Zhou,Sanjay Zodpey,Liesl Zühlke,Mohsen Naghavi,Christopher J L Murray +1028 more
TL;DR: Non-communicable diseases comprised the greatest fraction of deaths, contributing to 73·4% (95% uncertainty interval [UI] 72·5–74·1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional causes accounted for 18·6% (17·9–19·6), and injuries 8·0% (7·7–8·2).
Journal ArticleDOI
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Tetsu Akiyama,J Ishida,Shinsaku Nakagawa,Hiroshi Ogawara,Shinya Watanabe,N Itoh,M Shibuya,Yasuo Fukami +7 more
TL;DR: Genistein inhibited the EGF-stimulated increase in phosphotyrosine level in A431 cells and scarcely inhibited the enzyme activities of serine- and threonine-specific protein kinases such as cAMP-dependent protein kinase, phosphorylase kinases, and the Ca2+/phospholipid-dependent enzymeprotein kinase C.
Journal ArticleDOI
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
TL;DR: It is suggested that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases.
Journal ArticleDOI
The biochemistry and medical significance of the flavonoids.
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
Journal ArticleDOI
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
Fusheng Yang,Giselle P. Lim,Giselle P. Lim,Aynun N. Begum,Aynun N. Begum,Oliver J. Ubeda,Oliver J. Ubeda,Mychica Simmons,Mychica Simmons,Surendra S. Ambegaokar,Surendra S. Ambegaokar,Pingping P. Chen,Pingping P. Chen,Rakez Kayed,Charles G. Glabe,Sally A. Frautschy,Sally A. Frautschy,Gregory M. Cole,Gregory M. Cole +18 more
TL;DR: It is suggested that low dose curcumin effectively disaggregates Aβ as well as prevents fibril and oligomer formation, supporting the rationale forCurcumin use in clinical trials preventing or treating AD.