Osteoarthritis: the genesis of pain.
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TLDR
A better understanding of these multifactorial components of OA pain will lead to the development of more effective and safer pain treatments, making targeted therapy problematic.Abstract:
OA is a painful joint disease that predominantly affects the elderly. Pain is the primary symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms are complex and have only recently been determined. Both peripheral and central processes are involved in creating the OA pain experience, making targeted therapy problematic. Nociceptive, inflammatory and neuropathic pains are all known to occur in OA, but to varying degrees in a patient- and time-specific manner. A better understanding of these multifactorial components of OA pain will lead to the development of more effective and safer pain treatments.read more
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The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review.
TL;DR: The role of PI3K/AKT/mTOR signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation is highlighted, and how this signaling pathway affects development of the disease is discussed.
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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cindy G. Boer,Konstantinos Hatzikotoulas,Lorraine Southam,Lilja Stefansdottir,Yanfei Zhang,Rodrigo Coutinho de Almeida,Tian T Wu,Jie Zheng,April Hartley,Maris Teder-Laving,Anne Heidi Skogholt,Chikashi Terao,Eleni Zengini,George Alexiadis,Andrei Barysenka,Gyda Bjornsdottir,Maiken Elvestad Gabrielsen,Arthur Gilly,Thorvaldur Ingvarsson,Marianne B Johnsen,Helgi Jonsson,Margreet Kloppenburg,Almut Luetge,Sigrun H. Lund,Reedik Mägi,Massimo Mangino,Rob G H H Nelissen,Manu Shivakumar,Julia Steinberg,Hiroshi Takuwa,Laurent F. Thomas,Margo Tuerlings,Hunt All-In Pain,George C. Babis,Jason Pui Yin Cheung,Jae Hee Kang,Peter Kraft,Steven A Lietman,Dino Samartzis,P. Eline Slagboom,Kari Stefansson,Unnur Thorsteinsdottir,Jonathan H Tobias,André G. Uitterlinden,Bendik S. Winsvold,John-Anker Zwart,George Davey Smith,Pak C. Sham,Gudmar Thorleifsson,Tom R. Gaunt,Andrew P. Morris,Ana M. Valdes,Aspasia Tsezou,Kathryn S.E. Cheah,Shiro Ikegawa,Kristian Hveem,Tõnu Esko,J. Mark Wilkinson,Ingrid Meulenbelt,Ming Ta Michael Lee,Joyce B. J. van Meurs,Unnur Styrkarsdottir,Eleftheria Zeggini +62 more
TL;DR: A genome-wide association study meta-analysis across 826,690 individuals and identifies 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before.
Journal ArticleDOI
Recent advances in the treatment of osteoarthritis.
TL;DR: The recent advances in phenotype-specific treatment options are discussed and their applicability for use in personalized OA therapy is evaluated.
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Intra-articular drug delivery systems for joint diseases
TL;DR: This review highlights recent developments in IA therapy, with a special emphasis on current and emerging therapeutic carriers and their potential to deliver disease‐modifying treatment modalities for arthritis.
Journal ArticleDOI
Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial
Pascal Richette,Augustin Latourte,Jérémie Sellam,Daniel Wendling,Muriel Piperno,Philippe Goupille,Yves-Marie Pers,Florent Eymard,Sébastien Ottaviani,Paul Ornetti,René-Marc Flipo,Bruno Fautrel,Olivier Peyr,Jean Pierre Bertola,Eric Vicaut,Xavier Chevalier +15 more
TL;DR: Tocilizumab was no more effective than placebo for pain relief in patients with hand osteoarthritis, and adverse events were slightly more frequent in the tocilIZumab than placebo group.
References
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