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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Singlet Oxygen "Afterglow" Therapy with NIR-II Fluorescent Molecules.
TL;DR: In this article, three boron dipyrromethene (BODIPY) dyes are synthesized to demonstrate that anthracence-functionalized BODIPy, namely ABDPTPA, is an efficient heavy-atom-free photosensitizer for the reversible capture and release of 1 O2.
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RGD-Human Serum Albumin Conjugates as Efficient Tumor Targeting Probes:
Kai Chen,Jin Xie,Xiaoyuan Chen +2 more
TL;DR: An RGD-based protein conjugate with prolonged circulation half-life for NIRF imaging of tumor integrin αvβ3 expression is developed and may be generalizable for other peptide-based probes to be conjugated with HSA for prolonged tumor contrast and improved pharmacokinetics.
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Novel "Add-On" Molecule Based on Evans Blue Confers Superior Pharmacokinetics and Transforms Drugs to Theranostic Agents
Haojun Chen,Orit Jacobson,Gang Niu,Ido D. Weiss,Dale O. Kiesewetter,Yi Liu,Ying Ma,Hua Wu,Xiaoyuan Chen +8 more
TL;DR: Conjugation of the novel add-on molecule, NMEB or DMEB, to potential tracers or therapeutic agents improved blood half-life and tumor uptake and could transform such agents into theranostic entities.
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Positron emission tomography imaging of poststroke angiogenesis.
Weibo Cai,Raphael Guzman,Andrew R. Hsu,Hui Wang,Kai Chen,Guohua Sun,Atul Gera,Raymond Choi,Tonya M. Bliss,Lina He,Zibo Li,Anne Lise D. Maag,Nobutaka Hori,Heng Zhao,Michael E. Moseley,Gary K. Steinberg,Xiaoyuan Chen +16 more
TL;DR: In vivo imaging of VEGFR expression could become a significant clinical tool to plan and monitor therapies aimed at improving poststroke angiogenesis in a rat stroke model for the first time.
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Label-Free Visualization of Early Cancer Hepatic Micrometastasis and Intraoperative Image-Guided Surgery by Photoacoustic Imaging.
TL;DR: PAI was able to detect metastases as small as approximately 400 μm at a depth of up to 7 mm in vivo—a size that is smaller than can be detected with ultrasound and MRI, which offers a rapid and effective complementary clinical imaging application to noninvasively detect micrometastases and guide intraoperative resection.