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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Molecular targeting of CEACAM6 using antibody probes of different sizes.
Gang Niu,Yanal Murad,Haokao Gao,Shuo Hu,Ning Guo,Orit Jacobson,Thanh-Dung Nguyen,Jianbing Zhang,Xiaoyuan Chen +8 more
TL;DR: The data supported that the heavy chain antibody 2A3-mFc is superior to the single domain antibody and the full-length antibody with regard to tumor detection and pharmacokinetics, which has great potential to be developed for CEACAM6-targeted pancreatic cancer imaging and therapy.
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Nanoformulated ABT-199 to effectively target Bcl-2 at mitochondrial membrane alleviates airway inflammation by inducing apoptosis.
Bao-ping Tian,Fangyuan Li,Ruiqing Li,Xi Hu,Tianwen Lai,Jingxiong Lu,Yun Zhao,Yang Du,Zeyu Liang,Chen Zhu,Wei Shao,Wen Li,Zhihua Chen,Xiaolian Sun,Xiaoyuan Chen,Songmin Ying,Daishun Ling,Huahao Shen +17 more
TL;DR: Nf-ABT-199 was proven to significantly alleviate airway inflammation by effectively inducing eosinophil apoptosis and inhibiting both inflammatory cell infiltration and mucus hypersecretion and showed no obvious influence on cell viability, airway epithelial barrier and liver function, implying excellent biocompatibility and with non-toxic effect.
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Multiplexed PET Probes for Imaging Breast Cancer Early Response to VEGF121/rGel Treatment
Min Yang,Haokao Gao,Haokao Gao,Xilin Sun,Yongjun Yan,Qimeng Quan,Wendy Zhang,Khalid A. Mohamedali,Michael G. Rosenblum,Gang Niu,Xiaoyuan Chen +10 more
TL;DR: Overall, longitudinal imaging studies with 4 PET tracers demonstrated the feasibility and usefulness of multiplexed probes for quantitative measurement of antitumor effects of VEGF₁₂₀/rGel at the early stage of treatment.
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Molecular imaging can accelerate anti-angiogenic drug development and testing
TL;DR: Angiogenesis is one of the fundamental processes during tumor growth and disease progression, and is regulated by numerous molecular pathways, including VEGF, matrix metalloproteinases (MMPs), endoglin, integrin αvβ3 and E-selectin, which could serve as targets for molecular imaging.
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PET of Glucagonlike Peptide Receptor Upregulation After Myocardial Ischemia or Reperfusion Injury
Haokao Gao,Haokao Gao,Dale O. Kiesewetter,Xiao-Xiang Zhang,Xinglu Huang,Ning Guo,Ning Guo,Lixin Lang,Naoki Hida,Hui Wang,Haichang Wang,Feng Cao,Gang Niu,Xiaoyuan Chen +13 more
TL;DR: Noninvasive PET using 18F-FBEM-Cys40-exendin-4 revealed a dynamic pattern of GLP-1R upregulation in the infarcted/ischemic area after MI/R, which will deepen the understanding of the mechanism of the cardioprotective effect of GLp-1 and its analogs and potentially provide guidance for optimization of the time frame of therapeutic intervention.