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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
18F-FPPRGD2 and 18F-FDG PET of Response to Abraxane Therapy
Xilin Sun,Yongjun Yan,Shuanglong Liu,Qizhen Cao,Min Yang,Nouri Neamati,Baozhong Shen,Gang Niu,Xiaoyuan Chen +8 more
TL;DR: 18F-FPPRGD2 PET is superior to 18F-FDG PET in monitoring early response to treatment, favoring its potential clinical translation and Abraxane-mediated downregulation of integrin αvβ3 expression on tumor endothelial cells can be quantitatively visualized by PET.
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68Ga-BBN-RGD PET/CT for GRPR and Integrin αvβ3 Imaging in Patients with Breast Cancer.
Jingjing Zhang,Feng Mao,Gang Niu,Li Peng,Lixin Lang,Fang Li,Hongyan Ying,Huanwen Wu,Boju Pan,Zhaohui Zhu,Xiaoyuan Chen +10 more
TL;DR: 68Ga-BBN-RGD PET/CT may be of great value in discerning both primary breast cancers, axillary lymph node metastasis and distant metastases and significant uptake of a new type of dual integrin αvβ3 and GRPR targeting radiotracer in both the primary lesion and the metastases of breast cancer.
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PEGylated TNF-related apoptosis-inducing ligand (TRAIL) analogues: pharmacokinetics and antitumor effects.
TL;DR: The findings suggest that TRAIL derivatized with PEG of an appropriate M(w) might be useful antitumor agent with protracted activity.
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Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding.
Haojun Chen,Guohao Wang,Lixin Lang,Orit Jacobson,Dale O. Kiesewetter,Yi Liu,Ying Ma,Xianzhong Zhang,Hua Wu,Lei Zhu,Gang Niu,Xiaoyuan Chen +11 more
TL;DR: A novel platform for developing long lasting therapeutics by conjugating a small molecular albumin binding moiety, truncated Evans blue, to either peptides or proteins, which has considerable potential to treat type 2 diabetes.
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Recent Advances in Stimuli-Responsive Platforms for Cancer Immunotherapy.
Ling Li,Zhen Yang,Xiaoyuan Chen +2 more
TL;DR: This Account introduces the recent progress of the group and others on the development of stimuli-responsive platforms for cancer immunotherapy, and summarizes the general chemical design for constructing stimuli- responsive delivery platforms targeting immune targets at distinct locations.