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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
TL;DR: It is reported that the mammalian homolog of the yeast mitochondrial disulfide relay protein Mia40 (CHCHD4) is necessary for the respiratory-dependent translocation of p53 into the mitochondria.
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Evans Blue Attachment Enhances Somatostatin Receptor Subtype-2 Imaging and Radiotherapy
Rui Tian,Orit Jacobson,Gang Niu,Dale O. Kiesewetter,Zhantong Wang,Guizhi Zhu,Ying Ma,Gang Liu,Xiaoyuan Chen +8 more
TL;DR: The coupling of a targeted peptide, a therapeutic radionuclide, and the EB‑based albumin binding provides for effective treatment of SSTR2-containing tumors.
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Safety, Pharmacokinetics, and Dosimetry of a Long-Acting Radiolabeled Somatostatin Analog 177Lu-DOTA-EB-TATE in Patients with Advanced Metastatic Neuroendocrine Tumors
Jingjing Zhang,Jingjing Zhang,Hao Wang,Orit Jacobson,Yuejuan Cheng,Gang Niu,Fang Li,Chunmei Bai,Zhaohui Zhu,Xiaoyuan Chen +9 more
TL;DR: By introducing an albumin-binding moiety, 177Lu-DOTA-EB-TATE showed remarkably higher uptake and retention in NETs as well as significantly increased accumulation in the kidneys and red marrow.
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Ortho-Stabilized (18) F-Azido Click Agents and their Application in PET Imaging with Single-Stranded DNA Aptamers.
Lu Wang,Orit Jacobson,Din Avdic,Benjamin H. Rotstein,Ido D. Weiss,Lee Collier,Xiaoyuan Chen,Neil Vasdev,Steven H. Liang +8 more
TL;DR: A high-yielding direct radiofluorination for azido (18) F-arenes was achieved through the development of an ortho-oxygen-stabilized iodonium derivative (OID) and it is demonstrated that this OID approach is a convenient and highly efficient way of labeling and tracking biomolecules.
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Small-Animal PET of Melanocortin 1 Receptor Expression Using a 18F-Labeled α-Melanocyte-Stimulating Hormone Analog
Zhen Cheng,Lan Zhang,Edward E. Graves,Zhengming Xiong,Mangal Dandekar,Xiaoyuan Chen,Sanjiv S. Gambhir +6 more
TL;DR: 18F-FB-NAPamide is a promising molecular probe for α-MSH receptor-positive melanoma PET and warrants further study, indicating that 18F- FB-Napamide specifically recognizes the MC1R in living mice.