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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Bacteria-Responsive Nanoliposomes as Smart Sonotheranostics for Multidrug Resistant Bacterial Infections.
Xin Pang,Xin Pang,Qicai Xiao,Yi Cheng,En Ren,Lanlan Lian,Yang Zhang,Haiyan Gao,Xiaoyong Wang,Wingnang Leung,Xiaoyuan Chen,Gang Liu,Chuanshan Xu +12 more
TL;DR: A sonotheranostic strategy to achieve bacteria-specific labeling and visualized sonodynamic therapy (SDT) against MDR bacteria is reported, indicating that MLP18-mediated SDT could successfully eradicate inflammation and abscess from mice with bacterial myositis.
Journal ArticleDOI
Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy.
Xingshu Li,Sungsook Yu,Dayoung Lee,Gyoungmi Kim,Buhyun Lee,Yejin Cho,Bi Yuan Zheng,Mei Rong Ke,Jian-Dong Huang,Ki Taek Nam,Xiaoyuan Chen,Juyoung Yoon +11 more
TL;DR: In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcC, an attractive strategy for overcoming the limitations of photodynamic cancer therapy.
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Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics.
Rui Tian,Qiao Zeng,Shoujun Zhu,Joseph Lau,Swati Chandra,Robert Ertsey,Kenneth S. Hettie,Tarn Teraphongphom,Zhubin Hu,Gang Niu,Dale O. Kiesewetter,Haitao Sun,Xiaodong Zhang,Alexander L. Antaris,Bernard R. Brooks,Xiaoyuan Chen +15 more
TL;DR: This study engineered a supramolecular assembly of protein complex with lodged cyanine dyes to produce a brilliant NIR-II fluorophore, providing a Nir-II quantum yield of 21.2% with prolonged circulation time and afforded high-resolution microvessel imaging.
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Reprogramming Tumor-Associated Macrophages by Nanoparticle-Based Reactive Oxygen Species Photogeneration.
TL;DR: Reprogrammed TAMs to an antitumor M1 phenotype using precision nanoparticle-based reactive oxygen species photogeneration demonstrated superior efficiency and efficacy over lipopolysaccharide stimulation and could effectively eradicate tumors, inhibit metastasis, and further prevent their recurrence.
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Synergistic thermoradiotherapy based on PEGylated Cu3BiS3 ternary semiconductor nanorods with strong absorption in the second near-infrared window.
TL;DR: It is demonstrated that a small quantity of PEGylated Cu3BiS3 NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy.