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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models
Junting Liu,Yabin Wang,Xiaochao Qu,Xiangsi Li,Xiaopeng Ma,Runqiang Han,Zhenhua Hu,Xueli Chen,Dongdong Sun,Rongqing Zhang,Duofang Chen,Dan Chen,Xiaoyuan Chen,Jimin Liang,Feng Cao,Jie Tian +15 more
TL;DR: The data suggest that the reconstruction based on heterogeneous mouse model is more accurate in localization and quantification than the homogeneity mouse model with appropriate optical parameters and that BLT allows super-early tumor detection in vivo based on tomographic reconstruction of heterogeneous mice model signal.
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Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide-paclitaxel conjugate in mice with breast cancer.
TL;DR: The results demonstrate that integrin-targeted delivery of paclitaxel allows preferential cytotoxicity to Integrin-expressing tumor cells and tumor vasculature.
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68Ga-NOTA-PRGD2 PET/CT for Integrin Imaging in Patients with Lung Cancer
Kun Zheng,Naixin Liang,Jingjing Zhang,Lixin Lang,Wei Zhang,Shanqing Li,Jun Zhao,Gang Niu,Fang Li,Zhaohui Zhu,Xiaoyuan Chen +10 more
TL;DR: This study indicates the efficacy of 68Ga-NOTA-PRGD2 PET/CT in lung cancer diagnosis and shows significant advantage over 18F-FDG PET/ CT in judging metastatic lymph nodes with higher specificity.
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PET of Insulinoma Using 18F-FBEM-EM3106B, a New GLP-1 Analogue
Haokao Gao,Gang Niu,Min Yang,Qimeng Quan,Ying Ma,Eunice N. Murage,Jung-Mo Ahn,Dale O. Kiesewetter,Xiaoyuan Chen +8 more
TL;DR: High tracer uptake in INS-1 tumors and receptor specificity in bothINS-1 tumor and pancreas are confirmed and the favorable characteristics of (18)F-FBEM-EM3106B, such as high specific activity and high tumor uptake, and high tumors to nontarget uptake, demonstrate that it is a promising tracer for clinical insulinoma imaging.
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Monitoring of the Biological Response to Murine Hindlimb Ischemia With 64Cu-Labeled Vascular Endothelial Growth Factor-121 Positron Emission Tomography
Jürgen K. Willmann,Kai Chen,Hui Wang,Ramasamy Paulmurugan,Mark D. Rollins,Weibo Cai,David S. Wang,Ian Y. Chen,Olivier Gheysens,Martin Rodriguez-Porcel,Xiaoyuan Chen,Sanjiv S. Gambhir +11 more
TL;DR: 64Cu-VEGF121 positron emission tomography allows longitudinal spatial and quantitative monitoring of VEGFR2 expression in murine hindlimb ischemia and indirectly visualizes enhanced angiogenesis stimulated by treadmill exercise training.