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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma.
Zheyu Shen,Ting Liu,Zhen Yang,Zijian Zhou,Wei Tang,Wenpei Fan,Yijing Liu,Jing Mu,Ling Li,Vladimir I. Bregadze,Swadhin K. Mandal,Anna A. Druzina,Zhenni Wei,Xiao-Zhong Qiu,Aiguo Wu,Xiaoyuan Chen +15 more
TL;DR: ES-GON-rBSA-LF-RGD2 exhibited high biocompatibility and can transport across the in vitro BBB model and the in vivo BBB of mice due to its small particle size and LF receptor mediated transcytosis.
Journal ArticleDOI
NIR-emitting quantum dot-encoded microbeads through membrane emulsification for multiplexed immunoassays
Xiebing Wang,Gang Wang,Wanwan Li,Bingxia Zhao,Bin Xing,Yuankui Leng,Hongjing Dou,Kang Sun,Lisong Shen,Xiangliang Yuan,Jiyu Li,Kun Sun,Junsong Han,Huasheng Xiao,Yue Li,Peng Huang,Xiaoyuan Chen +16 more
TL;DR: A detection platform combining NIR-emitting CdSeTe/CdS/ZnS QD-encoded microbeads and Beckman Coulter FC 500 flow cytometry with one laser is successfully used to conduct a 2-plex hybridization assay for hepatitis B surface antigen, hepatitis B e antigen, and hepatitis B core antibody.
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Longitudinal PET imaging of doxorubicin-induced cell death with 18F-Annexin V.
Shuo Hu,Dale O. Kiesewetter,Lei Zhu,Ning Guo,Haokao Gao,Gang Liu,Gang Liu,Naoki Hida,Lixin Lang,Gang Niu,Xiaoyuan Chen +10 more
TL;DR: 18 F-Annexin V PET imaging is sensitive enough to allow visualization of doxorubicin-induced cell death in UM-SCC-22B xenograft model and will be helpful to monitor early response to chemotherapeutic anti-cancer drugs.
Journal ArticleDOI
Application of 68Ga-PRGD2 PET/CT for αvβ3-integrin Imaging of Myocardial Infarction and Stroke
Yi Sun,Yong Zeng,Yi-Cheng Zhu,Feng Feng,Wei-Hai Xu,Chenxi Wu,Bing Xing,Weihong Zhang,Peiling Wu,Liying Cui,Renzhi Wang,Fang Li,Xiaoyuan Chen,Zhaohui Zhu +13 more
TL;DR: 68Ga-PRGD2 uptake was observed around the ischemic region in both myocardial infarction and stroke patients, which was correlated with the disease phase and severity.
Journal ArticleDOI
Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy.
Yuan Liu,Christina S. Gong,Lisen Lin,Zijian Zhou,Yijing Liu,Zhen Yang,Zheyu Shen,Guocan Yu,Zhantong Wang,Sheng Wang,Ying Ma,Wenpei Fan,Liangcan He,Gang Niu,Yunlu Dai,Xiaoyuan Chen +15 more
TL;DR: This work developed a facile in-situ growth method to integrate MOF nanoparticle into inorganic nanomaterial and designed a fluorescence switch to trigger enhanced photodynamic therapy efficacy and provides insight to the rational design of multifunctional MOF-inorganic Nanomaterial complexes.