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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
W-doped TiO2 nanoparticles with strong absorption in the NIR-II window for photoacoustic/CT dual-modal imaging and synergistic thermoradiotherapy of tumors.
Ke Gao,Wenzhi Tu,Xujiang Yu,Farooq Ahmad,Xiannan Zhang,Weijie Wu,Xiao An,Xiaoyuan Chen,Wanwan Li +8 more
TL;DR: This newly developed PEGylated W-doped TiO2 (WTO) nanoparticles (NPs) synthesized via a facile organic route can absorb both NIR-II laser and ionizing radiation with negligible toxicity and rapid clearance, therefore it has great promise for applications in imaging and therapeutics in biomedicine.
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Site-specific labeling of scVEGF with Fluorine-18 for positron emission tomography imaging
TL;DR: In this article, a site-specific conjugation of (18)F-FBEM to a thiol group in Cys-tag of scVEGF at room temperature was presented.
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Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID-19 Cytokine Storm.
Qian-Fang Meng,Rui Tian,Haiyi Long,Xianjia Wu,Jialin Lai,Olga Zharkova,Jiong-Wei Wang,Xiaoyuan Chen,Lang Rao +8 more
TL;DR: In this paper, potential mechanisms of COVID-19 cytokine storm are first discussed, and relevant therapeutic strategies and ongoing clinical trials are then reviewed, and recent research involving emerging biomaterials for improving antibody-based and broad-spectrum cytokine neutralization is summarized.
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Development of a New Thiol Site-Specific Prosthetic Group and Its Conjugation with [Cys(40)]-exendin-4 for in Vivo Targeting of Insulinomas
Xuyi Yue,Dale O. Kiesewetter,Jinxia Guo,Jinxia Guo,Zhongchan Sun,Xiao-Xiang Zhang,Lei Zhu,Lei Zhu,Gang Niu,Ying Ma,Lixin Lang,Xiaoyuan Chen +11 more
TL;DR: Positron emission tomography results showed that the new thiol-specific tracer, N-5-[(18)F]FPenM-[cys(40)]-exendin-4, had high tumor uptake and rapid liver and kidney clearance, which was comparable to the imaging results with [(18]F]FBEM-[ cys( 40)]- exend in-4 reported by the group.
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Chemical reactions in supercritical carbon dioxide
TL;DR: In this article, supercritical fluids are used as environmentally benign solvents for chemical synthesis, which is one of the new approaches in the "greening" of chemistry, and is the most widely used gas for carbon dioxide.