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Xiaoyuan Chen
Researcher at National University of Singapore
Publications - 1270
Citations - 115993
Xiaoyuan Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Photothermal therapy & Medicine. The author has an hindex of 149, co-authored 994 publications receiving 89870 citations. Previous affiliations of Xiaoyuan Chen include Brown University & University of Southern California.
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Journal ArticleDOI
Monodisperse and Uniform Mesoporous Silicate Nanosensitizers Achieve Low-Dose X-Ray-Induced Deep-Penetrating Photodynamic Therapy.
Wenjing Sun,Tianhang Shi,Li Luo,Xiaomei Chen,Peng Lv,Ying Lv,Yixi Zhuang,Jinjie Zhu,Gang Liu,Xiaoyuan Chen,Hongmin Chen +10 more
TL;DR: Both in vitro and in vivo experiments demonstrate that the silicate nanosensitizers can accumulate effectively in tumors and achieve significant inhibitory effect on tumor progression under low-dose X-ray irradiation, while minimally affecting normal tissues.
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Improved Tumor Uptake by Optimizing Liposome Based RES Blockade Strategy.
Xiaolian Sun,Xuefeng Yan,Orit Jacobson,Wenjing Sun,Zhantong Wang,Xiao Tong,Yuqiong Xia,Daishun Ling,Xiaoyuan Chen +8 more
TL;DR: Quantitative PET imaging is a valuable tool to understand the fate of NMs in vivo and cationic liposomal pretreatment is a viable approach to reduce RES clearance, prolong circulation, and improve tumor uptake.
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Semimetal nanomaterials of antimony as highly efficient agent for photoacoustic imaging and photothermal therapy.
TL;DR: Semimetal nanomaterials of antimony (Sb) as highly efficient agent for photoacoustic imaging (PAI) and photothermal therapy (PTT), and intense PA signal was also observed after intratumoral injection of P EGylated Sb NPs and NIR laser irradiation due to their strong NIR photoabsorption, suggesting PEGylated NPs as a potential NIR PA agent.
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Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes
Dionysios C. Watson,Bryant C. Yung,Cristina Bergamaschi,Bhabadeb Chowdhury,Jenifer Bear,Dimitris Stellas,Aizea Morales-Kastresana,Jennifer Jones,Barbara K. Felber,Xiaoyuan Chen,George N. Pavlakis +10 more
TL;DR: The combination of bioreactor culture with TFF + SEC comprises a scalable, efficient method for the production of highly purified, bioactive EV carrying hetIL-15/lactadherin, which may be useful in targeted cancer immunotherapy approaches.
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Protein nanocages that penetrate airway mucus and tumor tissue.
Xinglu Huang,Jane Chisholm,Jane Chisholm,Jie Zhuang,Yanyu Xiao,Yanyu Xiao,Gregg A. Duncan,Xiaoyuan Chen,Jung Soo Suk,Justin Hanes,Justin Hanes +10 more
TL;DR: This work modified human ferritin nanocages using a unique PEGylation strategy, which provides a highly uniform, stable, and compact nanocarrier platform capable of overcoming multiple biological barriers, specifically penetration of airway mucus and tumor tissue, selective uptake by cancer cells, and drug release triggered only upon cell uptake.