Agilent Technologies

About: Agilent Technologies is a company organization based out in Santa Clara, California, United States. It is known for research contribution in the topics: Signal & Mass spectrometry. The organization has 7398 authors who have published 11518 publications receiving 262410 citations. The organization is also known as: Agilent Technologies, Inc..

Piezoelectric isolating transformer

Abstract: The piezoelectric isolating transformer (20) is characterized by an operating frequency range and includes a resonant structure (21) having at least one mechanical resonance in the operating frequency range. The resonant structure has an insulating substrate (30), a first electro-acoustic transducer (40) and a second electro-acoustic transducer (50). The substrate has a first major surface and a second major surface opposite the first major surface. The first electro-acoustic transducer is mechanically coupled to the first major surface. The second electro-acoustic transducer is mechanically coupled to the second major surface. One of the transducers (40, 50) is operable to convert input electrical power in the operating frequency range to acoustic energy that excites mechanical vibration in the resonant structure. The other of the transducers converts the mechanical vibration to output electrical power.

User-interactive system and method for integrating applications

Abstract: An application integrator that provides a user-interactive environment for integrating software applications having incompatible programming interfaces, such as production control and business enterprise systems The application integrator generally comprises a configuration system that provides a user with a view of the software applications' name space and graphically represents user-determined associations between data units from each of the software applications The graphical association represents a user-defined programmed interface, identifying which data units of the software applications to transfer and under what circumstances such transfers should occur This information is stored by the configuration system in a configuration repository A data server contains two distributed communication objects, each of which interfaces with a corresponding software application, and a mapping engine The mapping automatically transfer data units between the two software applications in a transaction-oriented manner and in accordance with the user's preferences as specified in the configuration repository

Nitric Oxide: The Forgotten Child of Tumor Metabolism

Abstract: Nitric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells and pathophysiological roles in cancer. NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients. Exogenous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and triggers angiogenesis. NO regulates posttranslational protein modifications, S-nitrosation, and genome-wide epigenetic modifications that can have both tumor-promoting and tumor-suppressing effects. We review mechanisms that link NO to cancer hallmarks, with a perspective of co-targeting NO metabolism with first-line therapies for improved outcome. We highlight the need for quantitative flux analysis to study NO in tumors.

Ultrasound transducer for three-dimensional imaging

Abstract: An ultrasound transducer assembly for use in a phased array ultrasound imaging system includes an array of ultrasound transducer elements having a two-dimensional transmitting and receiving surface that is curved in at least two orthogonal directions and conductors for connecting the transducer elements to electronic circuitry of the ultrasound imaging system. The array may include a curved, two-dimensional array of rows and columns of transducer elements. The transmitting and receiving surface is typically convex but may also be concave. The transmitting and receiving surface may be a portion of a spheroid or an ellipsoid. In one embodiment, the transmitting and receiving surface is configured as a portion of a spherical surface.

Readout method for molecular biological electronically addressable arrays

Abstract: A method for reading out data from microlocations of a microelectronic array involves activating multiple microlocations in parallel and simultaneously detecting the responses from the activated microlocations to determine concentrations of molecular biological material at each microlocation. In a preferred embodiment, the microelectronic array includes electronically addressable electrodes at each microlocation which can be individually activated via a control system. An electrochemiluminescent detection technique is used to detect the presence and determine the concentration of bound molecular biological material that is located at each microlocation. Electrochemiluminescent material is utilized because it gives off light when excited by an applied electrical field. With an addressable microelectronic array, electrical fields can be applied to various combinations of microlocations simultaneously to allow readout of several microlocations in parallel. This is in contrast to the laser-based readout approach which applies activation energy to one microlocation at a time by impacting each microlocation with a single laser system. Reading out multiple microlocations simultaneously in accordance with the invention can produce significant time savings in large arrays.