Agilent Technologies

About: Agilent Technologies is a company organization based out in Santa Clara, California, United States. It is known for research contribution in the topics: Signal & Mass spectrometry. The organization has 7398 authors who have published 11518 publications receiving 262410 citations. The organization is also known as: Agilent Technologies, Inc..

Using a ferrocenylsilane-based block copolymer as a template to produce nanotextured Ag surfaces: uniformly enhanced surface enhanced Raman scattering active substrates

Abstract: We report a method of fabricating nanotextured Ag surfaces using a template of self-assembled inorganic-containing block copolymer, polystyrene-b-polyferrocenylsilane. The Ag surfaces with periodically ordered nanoscale features created by the self-organized block copolymer are capable of producing enhanced Raman signals. Using benzenethiol as a probe molecule, an enhancement factor of up to 106 has been observed. More importantly, the enhancement is very uniform; less than 10% Raman signal variation has been obtained. Furthermore, since the size and spacing of the nanostructures can be adjusted by tailoring the polymer chain length, the electromagnetic field can potentially be tuned to achieve even higher surface-enhanced Raman scattering (SERS) activity. This inorganic-containing block copolymer template approach not only provides a simple and straightforward method to fabricate SERS active substrates but also offers a means to experimentally examine the SERS mechanism.

On the origin of the fast photoluminescence band in small silicon nanoparticles

Abstract: Colloidal suspensions of small silicon nanoparticles (diameter around 2nm) with fast and efficient ultraviolet-blue photoluminescence (PL) band are fabricated by enhanced electrochemical etching of Si wafers. The detailed study of photoluminescence excitation spectra in a wide range of excitation photon energies (270-420nm) reveals specific behavior of the Stokes shift of the fast PL band that agrees well with theoretical calculation of optical transitions in small silicon nanocrystals and is distinct from emission of silicon dioxide defects.

Companion Diagnostics for Targeted Cancer Drugs - Clinical and Regulatory Aspects

Abstract: Companion diagnostics (CDx) holds the promise of improving the predictability of the oncology drug development process and become an important tool for the oncologist in relation to the choice of treatment for the individual patient. A number of drug-diagnostic co-development programs have already been completed successfully, and in the clinic, the use of several targeted cancer drugs is now guided by a CDx. This central role of the CDx assays has attracted the attention of the regulators, and especially the US FDA has been at the forefront in relation to developing regulatory strategies for CDx and the drug-diagnostic co-development project. For an increasing number of cancer patients the treatment selection will depend on the result generated by a CDx assay, and consequently this type of assay has become critical for the care and safety of the patients. In order to secure that the CDx assays have a high degree of analytical and clinical validity they must undergo an extensive non-clinical and clinical testing before release for routine patient management. This review will give a brief introduction to some of the scientific and medical challenges related to the CDx development with specific emphasis on the regulatory requirements in different regions of the world.

Method of fabricating thin film bulk acoustic resonator (FBAR) and FBAR structure embodying the method

Abstract: A method for fabricating an acoustic resonator, for example a Thin Film Bulk Acoustic Resonators (FBAR), on a substrate. A depression is etched and filled with sacrificial material. The FBAR is fabricated on the substrate spanning the depression, the FBAR having an etch hole. The depression may include etch channels in which case the FBAR may include etch holes aligned with the etch channels. A resonator resulting from the application of the technique is suspended in air and includes at least one etch hole and may include etch channels.