Journal ArticleDOI
Cleft lip and palate
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TLDR
Prevention is the ultimate objective for clefts of the lip and palate, and a prerequisite of this aim is to elucidate causes of the disorders.About:
This article is published in The Lancet.The article was published on 2009-11-21. It has received 1344 citations till now. The article focuses on the topics: Oral cleft & IRF6.read more
Citations
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Journal ArticleDOI
Cleft lip and palate: understanding genetic and environmental influences.
TL;DR: Using a combination of epidemiology, careful phenotyping, genome-wide association studies and analysis of animal models, several distinct genetic and environmental risk factors have been identified and confirmed for non-syndromic CLP.
Journal ArticleDOI
Genome-wide Association Studies Prospects and Challenges for Oral Health
TL;DR: The issues surrounding the genome-wide association study approach are discussed with emphasis on the prospects and challenges relevant to the oral health research community.
Journal ArticleDOI
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Terri H. Beaty,Jeffrey C. Murray,Mary L. Marazita,Ronald G. Munger,Ingo Ruczinski,Jacqueline B. Hetmanski,Kung Yee Liang,Tao Wu,Tao Wu,Tanda Murray,M. Daniele Fallin,Richard A. Redett,Gerald V. Raymond,Holger Schwender,Sheng Chih Jin,Margaret E. Cooper,Martine Dunnwald,Maria A. Mansilla,Elizabeth J. Leslie,Stephen Bullard,Andrew C. Lidral,Lina M. Moreno,Renato Menezes,Alexandre R. Vieira,Aline Petrin,Allen J. Wilcox,Rolv T. Lie,Ethylin Wang Jabs,Ethylin Wang Jabs,Yah Huei Wu-Chou,Philip Kuo Ting Chen,Hong Wang,Xiaoqian Ye,Xiaoqian Ye,Shangzhi Huang,Vincent Yeow,Samuel S. Chong,Sun Ha Jee,Bing Shi,Kaare Christensen,Mads Melbye,Kimberly F. Doheny,Elizabeth W. Pugh,Hua Ling,Eduardo E. Castilla,Andrew E. Czeizel,Lian Ma,L. Leigh Field,Lawrence C. Brody,Faith Pangilinan,James L. Mills,Anne M. Molloy,Peadar N. Kirke,James M. Scott,Mauricio Arcos-Burgos,Alan F. Scott +55 more
TL;DR: In this paper, case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate, and two previously identified regions (at chromosome 8q24 and IRF6) attained genomewide significance.
Book ChapterDOI
Epidemiology of oral clefts 2012: an international perspective.
TL;DR: This chapter is set out in three parts and seeks to address all three of the above areas: Birth defects in general and orofacial clefting in particular, access to care and evidence base.
Journal ArticleDOI
Bone regeneration and stem cells
Kristina Arvidson,Basem M. Abdallah,Lee Ann Applegate,Nicola Baldini,Elisabetta Cenni,Enrique Gómez-Barrena,Donatella Granchi,Moustapha Kassem,Moustapha Kassem,Yrjö T. Konttinen,Kamal Ahmed Mustafa,Dominique P. Pioletti,Dominique P. Pioletti,Tarvo Sillat,Anna Finne-Wistrand +14 more
TL;DR: Embryonic, foetal and adult stem cells in osteogenesis, specific features of bone cells needed to be advantageous for clinical use, and the development of therapeutic biological agents.
References
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Journal Article
A study of fluctuating dermatoglyphic asymmetry in the sibs and parents of cleft lip propositi.
C M Woolf,A D Gianas +1 more
TL;DR: The hypothesis that familial and sporadic cases of congenital cleft lip are different entities is supported and evidence for a genetic mechanism in the parents and sibs of the familial cases that may account for this congenital disorder and, concomitantly, increased fluctuating asymmetry is given.
Journal ArticleDOI
Bulging medial edge epithelial cells and palatal fusion.
Concepción Martínez-Álvarez,Rosa Bonelli,Consuelo Tudela,A. Gato,Jesús Mena,Sharon O'kane,Mark W. J. Ferguson +6 more
TL;DR: The expression pattern of E-Cadherin, beta-catenin, chondroitin sulphate proteoglycan,beta-Actin and vinculin as assayed by immunocytochemistry in these cells shows specific variations that suggest their importance in palatal shelf adhesion.
Journal ArticleDOI
A new reliable method for alveolar bone grafting at about 6 years of age.
TL;DR: When the timing of alveolar bone grafting is based on the eruptive progress of the permanent maxillary canine tooth, the surgical procedure is, by definition, delayed until the late mixed dentition phase.
Journal ArticleDOI
Infant TGF-alpha genotype, orofacial clefts, and maternal periconceptional multivitamin use.
TL;DR: Preliminary evidence is provided for a gene-nutrient interaction in risk of clefting among infants with uncommon TGFa genotypes and whose mothers did not use multivitamins periconceptionally.
Journal ArticleDOI
Agricultural chemical use and congenital cleft lip and/or palate.
TL;DR: The results imply that if exposures to agricultural chemicals are, in fact, risk factors for clefts, an expanded model that accounts for multiple pesticidal exposures may be more sensitive than consideration of season of exposure, as originally hypothesized.
Related Papers (5)
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Terri H. Beaty,Jeffrey C. Murray,Mary L. Marazita,Ronald G. Munger,Ingo Ruczinski,Jacqueline B. Hetmanski,Kung Yee Liang,Tao Wu,Tao Wu,Tanda Murray,M. Daniele Fallin,Richard A. Redett,Gerald V. Raymond,Holger Schwender,Sheng Chih Jin,Margaret E. Cooper,Martine Dunnwald,Maria A. Mansilla,Elizabeth J. Leslie,Stephen Bullard,Andrew C. Lidral,Lina M. Moreno,Renato Menezes,Alexandre R. Vieira,Aline Petrin,Allen J. Wilcox,Rolv T. Lie,Ethylin Wang Jabs,Ethylin Wang Jabs,Yah Huei Wu-Chou,Philip Kuo Ting Chen,Hong Wang,Xiaoqian Ye,Xiaoqian Ye,Shangzhi Huang,Vincent Yeow,Samuel S. Chong,Sun Ha Jee,Bing Shi,Kaare Christensen,Mads Melbye,Kimberly F. Doheny,Elizabeth W. Pugh,Hua Ling,Eduardo E. Castilla,Andrew E. Czeizel,Lian Ma,L. Leigh Field,Lawrence C. Brody,Faith Pangilinan,James L. Mills,Anne M. Molloy,Peadar N. Kirke,James M. Scott,Mauricio Arcos-Burgos,Alan F. Scott +55 more
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24
Stefanie Birnbaum,Stefanie Birnbaum,Kerstin U. Ludwig,Heiko Reutter,Stefan Herms,Michael Steffens,Michele Rubini,Carlotta Baluardo,Melissa Ferrian,Nilma Almeida de Assis,Margrieta A. Alblas,Sandra Barth,Jan Freudenberg,Carola Lauster,Gül Schmidt,Martin Scheer,Bert Braumann,Stefaan J. Bergé,Rudolf H. Reich,Franziska Schiefke,Alexander Hemprich,Simone Pötzsch,Régine P.M. Steegers-Theunissen,Bernd Pötzsch,Susanne Moebus,Bernhard Horsthemke,Franz-Josef Kramer,Thomas F. Wienker,Peter A. Mossey,Peter Propping,Sven Cichon,Per Hoffmann,Michael Knapp,Markus M. Nöthen,Elisabeth Mangold +34 more
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
Elisabeth Mangold,Kerstin U. Ludwig,Stefanie Birnbaum,Carlotta Baluardo,Melissa Ferrian,Stefan Herms,Heiko Reutter,Nilma Almeida de Assis,Taofik Al Chawa,Manuel Mattheisen,Michael Steffens,Sandra Barth,Nadine Kluck,Anna Paul,Jessica Becker,Carola Lauster,Gül Schmidt,Bert Braumann,Martin Scheer,Rudolf H. Reich,Alexander Hemprich,Simone Pötzsch,Bettina Blaumeiser,Susanne Moebus,Michael Krawczak,Stefan Schreiber,Thomas Meitinger,Hans Erich Wichmann,Régine P.M. Steegers-Theunissen,Franz Josef Kramer,Sven Cichon,Peter Propping,Thomas F. Wienker,Michael Knapp,Michele Rubini,Peter A. Mossey,Per Hoffmann,Markus M. Nöthen +37 more